Navigation Links
Study to identify functions of hypothetical genes in 2 infectious disease pathogens
Date:11/19/2013

The National Institute of Allergy and Infectious Diseases (NIAID) has awarded the University of Chicago $4.4 million over five years to study genes of unknown function in bacteria that cause plague and brucellosis.

Sean Crosson, PhD, associate professor of biochemistry and molecular biophysics will lead the effort to characterize hypothetical genesgenes revealed via genome sequencing that as yet have no defined functional roleas part of a new Functional Genomics program at the NIAID. These studies will be carried out in collaboration with Olaf Schneewind, MD, PhD, professor and chair of the Department of Microbiology.

A total of 102 genes encoding proteins and small regulatory RNA sequences in the bacteria Yersinia pestis, which causes plague, and Brucella abortus, which causes brucellosis, a livestock disease that can be transmitted to humans, will be investigated. Targets were selected based on preliminary studies by the Crosson and Schneewind research groups that indicated potential roles for these genes in infection. This research program will be centered at the Howard Taylor Ricketts Laboratory, a level 3 biocontainment facility housed on the campus of Argonne National Laboratory that was constructed in partnership between the NIH and The University of Chicago.

"We have an opportunity to study genes that no one has ever studied," Crosson said. "Assigning function to hypothetical genes can inform studies of all species that contain similar genes."

The University of Chicago researchers are particularly interested in better understanding how these hypothetical genes are related to the infection process. Both Y. pestis and B. abortus are transmitted to humans through animals, and gaining insight into the biological mechanisms for infection could have implications for human health and even bioterrorism.

"This information is very valuable to the infectious disease research community. Right now, researchers that encounter these genes in their genetic screens or expression experiments don't know what to do with them," Crosson said.

Together with collaborators from Argonne National Lab, this research team will use cross-disciplinary bioinformatic, biochemical and genetic approaches, and animal infection models, including fleas, to define gene function. In addition, they will utilize structural biology resources such as the Advanced Photon Source at Argonne to study the biochemical functions of proteins encoded by hypothetical genes.

"This project leverages many of the strengths of The University of Chicago and Argonne. We're a group of experimental biologists, biophysicicts, chemists and bioinformaticians coming together to expand our knowledge of microbial gene function," Crosson said.


'/>"/>

Contact: Kevin Jiang
kevin.jiang@uchospitals.edu
773-795-5227
University of Chicago Medical Center
Source:Eurekalert

Related biology news :

1. Bone marrow mononuclear stem cells show no new gains in heart function says TIME study
2. Drexel study: Consumers order a less unhealthy meal when the menu has nutritional labeling
3. Body mass index may predict heart disease risk for type-2 diabetic patients new study finds
4. Study shows wind turbines killed 600,000 bats last year
5. Clinical ovarian cancers display extensive genetic heterogeneity, study suggests multiple treatment
6. Frontiers in Agricultural Sustainability: Studying the Protein Supply Chain
7. USC study reveals a protein that keeps people -- and their skeletons -- organized
8. NIH grant funds multi-center study of mysterious trauma-induced hemorrhaging
9. ORNL study uses neutron scattering, supercomputing to demystify forces at play in biofuel production
10. Wireless sensors used to study meditations effect on heart health
11. Dont hold the anchovies: Study shows Peruvian fish worth more as food than as feed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2016)... , June 16, 2016 ... is expected to reach USD 1.83 billion by ... View Research, Inc. Technological proliferation and increasing demand ... are expected to drive the market growth. ... The development of advanced multimodal techniques ...
(Date:6/9/2016)... in attendance control systems is proud to announce the introduction of fingerprint attendance control ... right employees are actually signing in, and to even control the opening of doors. ... ... ... Photo - ...
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. ... a business relationship that includes integrating Syngrafii,s patented ... branch project. This collaboration will result in greater ... the credit union, while maintaining existing document workflow ... http://photos.prnewswire.com/prnh/20160606/375871LOGO ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT has ... Ontario biotechnology company, Propellon Therapeutics Inc. ... and commercialization of a portfolio of first-in-class WDR5 ... targets such as WDR5 represent an exciting class ... in precision medicine for cancer patients. Substantial advances ...
(Date:6/23/2016)... 2016  The Prostate Cancer Foundation (PCF) is pleased to announce ... cures for prostate cancer. Members of the Class of 2016 were selected from ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... , ... STACS DNA Inc., the sample tracking software company, today announced that ... joined STACS DNA as a Field Application Specialist. , “I am thrilled that ... of STACS DNA. “In further expanding our capacity as a scientific integrator, Hays brings ...
(Date:6/23/2016)... , June 23, 2016 ... Hematology Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 ... , the peer-reviewed journal from touchONCOLOGY, Andrew ... escalating cost of cancer care is placing an ... result of expensive biologic therapies. With the patents ...
Breaking Biology Technology: