Navigation Links
Study to identify functions of hypothetical genes in 2 infectious disease pathogens
Date:11/19/2013

The National Institute of Allergy and Infectious Diseases (NIAID) has awarded the University of Chicago $4.4 million over five years to study genes of unknown function in bacteria that cause plague and brucellosis.

Sean Crosson, PhD, associate professor of biochemistry and molecular biophysics will lead the effort to characterize hypothetical genesgenes revealed via genome sequencing that as yet have no defined functional roleas part of a new Functional Genomics program at the NIAID. These studies will be carried out in collaboration with Olaf Schneewind, MD, PhD, professor and chair of the Department of Microbiology.

A total of 102 genes encoding proteins and small regulatory RNA sequences in the bacteria Yersinia pestis, which causes plague, and Brucella abortus, which causes brucellosis, a livestock disease that can be transmitted to humans, will be investigated. Targets were selected based on preliminary studies by the Crosson and Schneewind research groups that indicated potential roles for these genes in infection. This research program will be centered at the Howard Taylor Ricketts Laboratory, a level 3 biocontainment facility housed on the campus of Argonne National Laboratory that was constructed in partnership between the NIH and The University of Chicago.

"We have an opportunity to study genes that no one has ever studied," Crosson said. "Assigning function to hypothetical genes can inform studies of all species that contain similar genes."

The University of Chicago researchers are particularly interested in better understanding how these hypothetical genes are related to the infection process. Both Y. pestis and B. abortus are transmitted to humans through animals, and gaining insight into the biological mechanisms for infection could have implications for human health and even bioterrorism.

"This information is very valuable to the infectious disease research community. Right now, researchers that encounter these genes in their genetic screens or expression experiments don't know what to do with them," Crosson said.

Together with collaborators from Argonne National Lab, this research team will use cross-disciplinary bioinformatic, biochemical and genetic approaches, and animal infection models, including fleas, to define gene function. In addition, they will utilize structural biology resources such as the Advanced Photon Source at Argonne to study the biochemical functions of proteins encoded by hypothetical genes.

"This project leverages many of the strengths of The University of Chicago and Argonne. We're a group of experimental biologists, biophysicicts, chemists and bioinformaticians coming together to expand our knowledge of microbial gene function," Crosson said.


'/>"/>

Contact: Kevin Jiang
kevin.jiang@uchospitals.edu
773-795-5227
University of Chicago Medical Center
Source:Eurekalert

Related biology news :

1. Bone marrow mononuclear stem cells show no new gains in heart function says TIME study
2. Drexel study: Consumers order a less unhealthy meal when the menu has nutritional labeling
3. Body mass index may predict heart disease risk for type-2 diabetic patients new study finds
4. Study shows wind turbines killed 600,000 bats last year
5. Clinical ovarian cancers display extensive genetic heterogeneity, study suggests multiple treatment
6. Frontiers in Agricultural Sustainability: Studying the Protein Supply Chain
7. USC study reveals a protein that keeps people -- and their skeletons -- organized
8. NIH grant funds multi-center study of mysterious trauma-induced hemorrhaging
9. ORNL study uses neutron scattering, supercomputing to demystify forces at play in biofuel production
10. Wireless sensors used to study meditations effect on heart health
11. Dont hold the anchovies: Study shows Peruvian fish worth more as food than as feed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... GARDENS, Fla. , April 11, 2017 /PRNewswire/ ... management and secure authentication solutions, today announced that ... by Intelligence Advanced Research Projects Activity (IARPA) to ... IARPA,s Thor program. "Innovation has been ... and IARPA,s Thor program will allow us to ...
(Date:4/11/2017)... , April 11, 2017 NXT-ID, Inc. ... technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate governance ... Gino ... we look forward to their guidance and benefiting from their ...
(Date:4/5/2017)... -- Today HYPR Corp. , leading innovator in ... the HYPR platform is officially FIDO® Certified . ... that empowers biometric authentication across Fortune 500 enterprises and ... 15 million users across the financial services industry, however ... suites and physical access represent a growing portion of ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... ... April 27, 2017 , ... During the ... review how testing for 1,25-Dihydroxyvitamin D can enhance clinical practice. Participants will learn ... 1,25 dihydroxyvitamin D. , Dr. Gregory Plotnikoff, senior consultant with Minnesota Personalized Medicine, ...
(Date:4/27/2017)... , April 27, 2017  Pendant Biosciences, Inc. ... innovative surface modification and drug delivery technologies, today announced ... Innovation, JLABS @ Toronto . ... Officer of Pendant Biosciences, noted, "We are excited to ... community, and are honored to be the ...
(Date:4/26/2017)... ... April 25, 2017 , ... LABS, Inc. (LABS) announced in December ... its extensive test menu: Nucleic Acid Testing (NAT) for ZIKV; and Enzyme Immunoassays (EIAs) ... to offer NAT screening for blood donors under an Investigational New Drug (IND) study ...
(Date:4/25/2017)... ... April 25, 2017 , ... As part of the Stago EdVantage Virtual ... testing for DIC in order to illuminate this clinical problem for people unfamiliar with ... patients resulting in a high degree of morbidity and mortality. DIC is a confusing ...
Breaking Biology Technology: