Navigation Links
Study supports DNA repair-blocker research in cancer therapy
Date:8/17/2009

BOSTON--Scientists at Dana-Farber Cancer Institute have uncovered the mechanism behind a promising new approach to cancer treatment: damaging cancer cells' DNA with potent drugs while simultaneously preventing the cells from repairing themselves.

The findings being reported in the Aug. 14 issue of Molecular Cell help explain the promising results being seen in clinical trials of compounds that force cancer cells with genetic damage to self-destruct instead of "resting" while their DNA undergoes repairs.

"What we have shown suggests that you can use these drugs to sensitize cancer cells to DNA-damaging chemotherapy," said Geoffrey Shapiro, MD, PhD, senior author of the report. "This is a mechanism by which these inhibitory drugs may be synergistic with DNA-damaging agents."

Interestingly, Shapiro said, when the same repair-blocking drugs were administered to normal, non-cancerous cells, the cells became less sensitive to DNA damage from a chemotherapy drug. This is an encouraging indication that repair-blocking drugs may selectively make cancer cells vulnerable to chemotherapy while protecting normal cells from DNA damage, the scientists said.

Cells' native capacity for fixing DNA damage is normally beneficial, but it can be problematic for cancer therapy as it enables tumor cells to become resistant to a number of standard drug agents. All cells progress through a series of phases -- called the cell cycle -- including quiescence, or resting, growth, and cell division. The transition from one phase to the next is regulated by "checkpoint" proteins that, among other things, are designed to prevent damaged, potentially dangerous cells from reproducing.

The body deals with DNA-damaged cells in two ways. It can order them to self-destruct through "programmed cell death," also known as apoptosis. Or, it can issue signals from the checkpoint proteins to put the cells into "cell cycle arrest," causing them to remain q
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. K-State lab gives researchers the tools to study porcine circovirus associated diseases
2. New study shows that cocoa flavanols can be preserved during cooking and baking
3. New study suggests possible genetic links between environmental toxins and multiple myeloma
4. New study reveals unexpected relationship between climate warming and advancing treelines
5. Stimulus funding helps K-State biochemist study eyes lens in diabetes, galactosemia patients
6. U of M study identifies risk factors of disordered eating in overweight youth
7. K-State researcher, collaborators study virulence of pandemic H1N1 virus
8. Study links virus to some cases of common skin cancer
9. Douglas-fir, geoducks make strange bedfellows in studying climate change
10. 1 in 6 health workers wont report in flu pandemic -- study by Ben-Gurion U. researchers
11. Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... BOSTON -- Nine researchers from Beth Israel ... included in "The World,s Most Influential Scientific Minds ... from Thomson Reuters ScienceWatch, a web resource for science ... scientists recognized as among the most influential "are performing ... to the advancement of their science," according to a ...
(Date:8/21/2014)... window? It consists of radiations in the 3.3 to ... water in biological tissues. New theoretical findings show that ... water window. These could be the basis of an ... biological samples or to be used in high-precision spectroscopy. ... needed to efficiently generate the harmonic radiationswhich are multiples ...
(Date:8/21/2014)... feeding tube connectors, designed by an international standards process, ... , According to an invited review published in the ... ( NCP ), the official journal of the American ... connectors will greatly reduce the occurrence of misconnection that ... Small-bore connectors, which are used to join medical devices, ...
Breaking Biology News(10 mins):BIDMC researchers named among 'the most influential scientific minds' 2BIDMC researchers named among 'the most influential scientific minds' 3Water window imaging opportunity 2New feeding tube connectors will improve patient safety 2
... A new study by top global fisheries experts presents ... The analysis of 61 species of "scombrids," which include ... include swordfish and marlins, classified seven as threatened with ... Red List of Threatened Species. University of Miami ...
... The Northwest Forest Plan enacted in 1993 was designed ... northern spotted owl, but researchers conclude in a new study ... carbon sequestration on public lands. When forest harvest levels ... after passage of this act, they became a significant carbon ...
... NEW YORK (July 22, 2011)A genetic study ... that the big-horned animals travel extensively across the ... to Wildlife Conservation Society researchers with the support ... Using a non-invasive technique that extracts DNA from ...
Cached Biology News:Double jeopardy: Tuna and billfish 2Northwest Forest Plan has unintended benefit - carbon sequestration 2World's largest sheep an international traveler 2World's largest sheep an international traveler 3
(Date:8/22/2014)... 2014 “Our nation's healthcare system ... national disgrace. Furthermore, every governmental and professional entity ... deplorable state of unorganized dysfunction shares in that ... merely serve as a device to use in ... failure(s) that have accumulated through the years leading ...
(Date:8/21/2014)... research team including DESY scientists has observed tiny quantum ... reports in the journal Science that the ... the nanodroplets. It is the first time that the ... samples of what is known as superfluid helium, have ... best expectations," says Andrey Vilesov of the University of ...
(Date:8/21/2014)... COLD SPRING, N.Y. , Aug. 21, 2014 ... today the launch of their Nutraceutical "TELO-20 for ... first and only Telomere-lengthening supplement in the world ... the ends of every chromosome in the body. ... the world,s leading experts in Telomere Science and ...
(Date:8/21/2014)... , Aug. 21, 2014 ... Immune Pharmaceuticals Inc., a biotechnology company, on its ... Immune previously traded on OTCQX®, the best marketplace ... OTC Markets Group. Logo - http://photos.prnewswire.com/prnh/20110118/MM31963LOGO ... on the successful execution of its growth strategy ...
Breaking Biology Technology:5 Great Mistakes in Healthcare and How to Fix Them by Dr. Ira Williams 2Scientists observe quantum vortices in cold helium droplets 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3OTC Markets Group Congratulates Immune Pharmaceuticals on NASDAQ Listing 2
... part of its ongoing efforts to improve the quality ... diagnosed with scoliosis, Axial Biotech, Inc., a company revolutionizing ... today announced that it has signed a multi-year agreement ... The agreement focuses on providing access to ...
... 2011 ,   Amsterdam ... human gene therapy, today announced the appointment of,Dr. Carlos ... AMT more than 25 years of pharmaceutical industry experience,most ... approvals at the European Medicines Agency (EMA),and U.S. Food ...
... Nottingham and using nanotechnology 100,000 times smaller than the thickness ... the vast energy of the Sun to produce clean fuel. ... Society,s annual Summer Science Exhibition which opens ,today [5 July ... have already found a way to produce hydrogen from water. ...
Cached Biology Technology:Axial Biotech Signs Agreement With Shriners Hospital for Children 2Axial Biotech Signs Agreement With Shriners Hospital for Children 3Amsterdam Molecular Therapeutics Appoints Dr. Carlos R. Camozzi as Chief Medical Officer 2Amsterdam Molecular Therapeutics Appoints Dr. Carlos R. Camozzi as Chief Medical Officer 3Putting sunshine in the tank 2
ABCA1 Immunogen: Mouse ABCA1-expressing HeLa stable transfectants. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Goat polyclonal to SART3 ( Abpromise for all tested applications). Antigen: Synthetic peptide: MSNADFAKLFLRK, corresponding to C terminal amino acids 951-963 of Human SART3 Entrez Gene ID: 9...
Hamartin/TSC1 (1B2) Mouse mAb Ship: Hot Store: -20 C...
synaptotagmin XIV-like [Source:RefSeq_peptide;Acc:NP_114120] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Biology Products: