Navigation Links
Study suggests statins may prevent diabetic-related blindness
Date:2/17/2011

Athens, Ga. New University of Georgia research has found that a statin drug that is often known by the brand-name Lipitor may help prevent blindness in people with diabetes.

In a study using diabetic rats, lead author Azza El-Remessy, assistant professor in the University of Georgia College of Pharmacy, and her colleagues found that statins prevent free radicals in the retina from killing nerves important to maintaining vision. The results of the study are published in the March edition of the journal Diabetologia.

"The exciting part is that there are now treatment options that are proven to be safe that can be immediately translated to patients," said El-Remessy.

Diabetic retinopathy is a leading cause of blindness in adults and is observed in most patients after 10 to 15 years of diabetes. There are no currently FDA-approved oral treatments for diabetic retinopathy, and surgical methods are expensive and painful, she added.

Uncontrolled diabetes and excessive glucose induces free radicals, which causes the eye to release a protein called pro-nerve growth factor, which normally matures into nerve growth factor (NGF) to protect the retinal nerves, explained El-Remessy. The free radicals that are generated by diabetes stop the maturation of proNGF into NGF, however, which leads to impaired neuronal function.

Using diabetic rats and isolated retinal cells cultured in high glucose, El-Remessy and colleagues found that oral treatment with the drug atorvastatin blocked the formation of free radicals in the retina, which restored proper levels of nerve growth factor and preserved neurons in the retina. "It removed the break on the pro-form nerve growth factor to develop into its mature form," she said. The drug was orally administered to rats in doses proportional to levels given to human patients with cardiovascular problems.

In a related study, also in the March edition of the journal Diabetologia
'/>"/>

Contact: Azza El-Remessy
aelremessy@georgiahealth.edu
706-721-6760
University of Georgia
Source:Eurekalert

Page: 1 2

Related biology news :

1. First-of-its-kind study shows benefits of electrical stimulation therapy for people paralyzed by spinal cord injury
2. Designing new molecular tools to study the life and death of a cancer cell
3. Scripps Research study sheds light on RNA on/off switches
4. Study finds massive flux of gas, in addition to liquid oil, at BP well blowout in Gulf
5. Pulmonary fibrosis inhibited by pentraxin-2/SAP in research study
6. NSF funds study of landscape restoration effects on Pennsylvania stream
7. VTT to study one of worlds oldest beers
8. Brandeis study shows economic impact of dengue virus in Americas
9. Field study of smoggy inversions to end
10. Road may disrupt migration, ruin Serengeti, study finds
11. Island-scale study reveals climate-change effects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... in the bladders of healthy women differ from ... incontinence, according to researchers from Loyola University Chicago ... published July 9, 2014, in the American Society ... that bacterial communities may play a role in ... is a common, yet poorly understood, condition with ...
(Date:7/9/2014)... Indiana state parks have helped restore the health of ... populations of white-tailed deer, a Purdue study shows. , ... of forest ecology, found that a 17-year-long Indiana Department ... parks has successfully spurred the regrowth of native tree ... , Jenkins said that while hunting may be ...
(Date:7/9/2014)... Sexual selection refers to species, selection for traits ... type of natural selection enhances opportunities to mate, the ... Biologists at the University of California, Riverside have now ... of a placenta are linked. Describing the life ... the family Poeciliidae, the researchers found that species with ...
Breaking Biology News(10 mins):Hunting gives deer-damaged forests in state parks a shot at recovery 2Biologists link sexual selection and placenta formation 2Biologists link sexual selection and placenta formation 3Biologists link sexual selection and placenta formation 4
... , NEW YORK, July 16, 2011 Experts from ... Langone Medical Center will present new research at the ... be held in Paris, France from July 16 ... mild cognitive impairment in retired football players, with Stella ...
... Ore. Nerve cells in the eye require vitamin C ... may mean vitamin C is required elsewhere in the brain ... at Oregon Health & Science University recently published in the ... retina need to be ,bathed, in relatively high doses of ...
... at Mount Sinai School of Medicine have found that ... or delay the progression of Alzheimer,s disease. The research, ... Family Professor in Neurology, and Professor of Psychiatry and ... Medicine, was published online in the current issue of ...
Cached Biology News:NYU Langone Medical Center's tip sheet to the 2011 Alzheimer's Association International Conference 2NYU Langone Medical Center's tip sheet to the 2011 Alzheimer's Association International Conference 3NYU Langone Medical Center's tip sheet to the 2011 Alzheimer's Association International Conference 4NYU Langone Medical Center's tip sheet to the 2011 Alzheimer's Association International Conference 5NYU Langone Medical Center's tip sheet to the 2011 Alzheimer's Association International Conference 6OHSU scientists discover new role for vitamin C in the eye -- and the brain 2Natural chemical found in grapes may protect against Alzheimer's disease 2
(Date:1/14/2014)... Communications, a leading provider of strategic communications services to corporations and ... the United States and Europe ... JD, is returning to the firm,s Washington, D.C. ... more than two years of service as Associate Commissioner for the ...
(Date:1/14/2014)... 2014 The largest international professional organization of ... therapeutic derivatives thereof has endorsed an educational program ... the challenges of adulterated herb and botanical products. ... The Society for Medicinal Plant and Natural ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 In recent ... motives and methods in product development and promotion has ... industry. This mistrust, fueled by concerns about the insidious ... by reports of spectacular fines to the world’s biggest ...
(Date:1/14/2014)... Ontario , Jan. 14, 2014   Kinaxis ®, provider ... SCM ) and sales and operations planning ( S&OP ) ... Biomanufacturing Summit , which will be held at the ... the conference, join Kinaxis customer Elisabeth Kaszas , Director ...
Breaking Biology Technology:Former FDA Associate Commissioner Returns To 3D Communications 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... Multiple births can be avoidedATLANTA, Jan. 30 For the ... to seek help after this week,s birth of octuplets ... births can be prevented with today,s advanced technologies."Infertility affects ... desiring to be pregnant to do is shy away ...
... Basic Sciences award in this inaugural edition of the ... by physicists Peter Zoller (Austria, 1952) and Ignacio Cirac ... science", in the words of the jury chaired by ... Cirac,s research is opening up vital new avenues for ...
... RANCHO CORDOVA, Calif., Jan. 29 ThermoGenesis,Corp. (Nasdaq: ... that process,and store adult stem cells, announced today it ... December 31, 2008, on Wednesday, February,4, 2009. , ... Management will host a conference ...
Cached Biology Technology:You Want To Have a Baby...But Not Eight 2Peter Zoller and Ignacio Cirac, awarded by the BBVA Foundation 2ThermoGenesis Corp. to Announce Second Quarter Fiscal 2009 Results on February 4, 2009 2
...
... Ribonuclease III (RNase III) from E. coli ... RNA (dsRNA) to dsRNA fragments that have ... results in dsRNA fragments of 12-15 bp. ... composed of canonical ribonucleotides as well as ...
Rabbit polyclonal to Peptide E ( Abpromise for all tested applications)....
Mouse monoclonal [6911] to E. coli K99 pilus ( Abpromise for all tested applications)....
Biology Products: