Navigation Links
Study suggests new strategy to prevent infertility, birth defects
Date:7/7/2011

Again, the age-associated changes seen in the free-fed mice aggregation of mitochondria into clumps and a drop in levels of ATP, the metabolic fuel produced by mitochondria were not seen in egg cells from the aged CR females.

While the mechanisms by which caloric restriction produces its effects are still being investigated, several of the metabolic pathways involve a regulator of DNA transcription called PGC-1α, which is known to modulate genes involved in controlling mitochondrial number and function. Tilly's team also found that egg cells from female mice lacking a functional PGC-1α gene who were allowed to free feed through adulthood maintained the same egg-cell quality as seen in the CR mice. However, combining CR with PGC-1α inactivation did not increase the effects beyond those achieved separately, which suggests that the two approaches work in a common pathway..

"While most of the work in the field of caloric restriction has been done in mice and other laboratory animals, over the past few years a number of studies have shown that several of the health benefits reported in aging mice are also seen in monkeys and perhaps in human populations that have chosen to limit their caloric intake," says Tilly, who is a professor of Obstetrics, Gynecology & Reproductive Biology at Harvard Medical School.

"If we find a way to safely reproduce in humans the effects we see in this study and even though this is a mouse study, we know these age-related egg cell defects are also seen in humans we may be able both to improve a woman's chance of getting pregnant and, for those who do need assisted reproductive technology, to improve the quality of the eggs we use to minimize if not eliminate the age-related increase in Down syndrome and other chromosomal disorders," he adds.


'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Long-term study shows effect of climate change on animal diversity
2. £2 million study to reveal workings of dementia genes
3. New study looks to define evangelicals and how they affect polling
4. CU-Boulder study suggests air quality regulations miss key pollutants
5. Researchers study acoustic communication in deep-sea fish
6. Study reveals homeowner perceptions in fire-prone areas
7. Researchers study how pistachios may improve heart health
8. Study: urban black bears live fast, die young
9. New study indicates link between weight gains during pregnancy and dieting history
10. Study reveals specific gene in adolescent men with delinquent peers
11. Sweat it out: UH study examines ability of sweat patches to monitor bone loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... a group of fish began exploring land and evolved into ... how these ancient fish used their fishy bodies and fins ... play remain scientific mysteries. , Researchers at McGill University ... living fish, called Polypterus , to help show what ... of the water. Polypterus is an African fish ...
(Date:8/27/2014)... An invasive grass species frequently found in forests has ... feed on American toads, a new University of Georgia ... introduced to the U.S. in the early 1900s, is ... spread to more than a dozen states in the ... roads and in forests, it can survive in widely ...
(Date:8/27/2014)... /PRNewswire-iReach/ -- The IEEE Engineering in Medicine and Biology ... International Conference (EMBC,14), this year being held at the ... Illinois , from Tuesday, August 26 through Saturday, ... industry professionals in science, medicine, and engineering are registered ... This year,s conference theme is ...
Breaking Biology News(10 mins):Walking fish reveal how our ancestors evolved onto land 2More wolf spiders feasting on American toads due to invasive grass, UGA study shows 2More wolf spiders feasting on American toads due to invasive grass, UGA study shows 3Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 2Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 3
... N.Y. (September 30, 2010) Autism Speaks is pleased ... Fellows. Made possible by a multi-year grant from the ... Morgan CEO Sir Dennis Weatherstone, eight fellowship projects were ... $448,000 over the next two years. The fellowship awards ...
... Iowa - An Iowa State University researcher searched for ... a type of mosquito that is not only a ... professor of entomology, along with colleagues from around the ... quinquefasciatus ) with various pathogens to see which mosquito ...
... will award up to $64 million over five years ... ideas that have the potential for extraordinary impact. ... program allows investigators to sidestep conventional stumbling blocks they ... such as the need for preliminary data or a ...
Cached Biology News:Autism Speaks awards second class of Dennis Weatherstone pre-doctoral fellowships 2Autism Speaks awards second class of Dennis Weatherstone pre-doctoral fellowships 3Iowa State University researcher examines mosquito gene for new disease response 2
(Date:8/27/2014)... WriteResult, LLC – a premier provider of ... superiority when it comes to meeting the needs of ... of their most recent study closeout on-time and with ... digital writing platform to collect Patient Reported Outcomes electronically ... drew data from a number of assessments including the ...
(Date:8/26/2014)... what they believe is the thinnest-possible semiconductor, a ... only three atoms thick. , The University of ... single-layer semiconductor materials can be connected in an ... result could be the basis for next-generation flexible ... and solar technologies. , "Heterojunctions are fundamental elements ...
(Date:8/26/2014)... Diego, CA, and Bellingham, WA (PRWEB) August 26, ... and optical engineering, visions for next-generation wearable technology, ... 2015 among numerous highlights at this year’s brighter, ... the San Diego, California, Convention Center. More than ... last week attended conferences, courses, an exhibition, and ...
(Date:8/26/2014)... (PRWEB) August 26, 2014 The 20 ... of ALS (YFALS) community issued the following statement on ... bringing awareness and driving new funding specifically for ALS ... of water and some ice would raise all this ... with our families, and on behalf of the entire ...
Breaking Biology Technology:A Perfect Record: WriteResult Maintains a 100% On-Time ePRO Record with Latest Irritable Bowel (IBS) Study Data Lock 2Scientists craft atomically seamless, thinnest-possible semiconductor junctions 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 3Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 4ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 2ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 3ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 4
... Peterson, president and CEO of ZyStor Therapeutics, Inc. ... for attendees of this year's Midwestern bioscience forum. , ... Wisconsin biotechnology companies with another presenter, Dr. Irene Hrusovsky, ... of molecular diagnostic products. , ,Like many of the ...
... engine optimization (SEO) tactics have one thing in common: ... and incorporating them into a web site, marketers can ... a desirable search engine ranking requires good information about ... website's industry or topic. A good place to start ...
... - CDW Corp. , a $6 billion-a-year information technology ... agreed to acquire the stock of Madison-based Berbee Information ... ,The acquisition, which has been approved by the boards of ... October, subject to regulatory approvals and approval by Berbee shareholders. ...
Cached Biology Technology:ZyStor to exhibit cell disorder treatments 2Search engine optimization: What's the word? 2Search engine optimization: What's the word? 3Berbee believes acquisition by CDW will make it a national IT player 2Berbee believes acquisition by CDW will make it a national IT player 3
... is the industry standard microarray image analysis ... imaging and analysis tools, visualizations, automation capabilities, ... is included with every GenePix scanner, and ... scanners and all types of arrays. A ...
... is the ideal instrument for budget-conscious labs that ... applications. Get Applied Biosystems proven PCR ... lab space without sacrificing results. Enhance ... Technology You Can Afford The Applied ...
... synthesis with a wide variety of purity levels, ... needs. Purity: IG(>50%), >70%, >80% ... Sequence Length: Up to 120 residues ... phosphorylation, D-amino acids, MAPs, KLH/BSA conjugation, and much ...
... The AquaMax DW4 liquid handling system from ... washing all in one instrument. The system ... dispensing and plate washing96-, 384- and 1536-welland ... washing. AquaMax DW4 has been optimized to ...
Biology Products: