Navigation Links
Study suggests genetic connection between short stature and arthritis
Date:1/13/2008

ANN ARBOR, Mich.---Common genetic variants linked to arthritis may also play a role in human height, a new study shows.

The international study was co-led by the University of Michigan School of Public Health. The journal Nature Genetics will publish the findings online Jan. 13.

The new study confirms observations by health professionals of a connection between decreased height and increased risk of osteoarthritis, the most common form of arthritis. Researchers speculate that both extremes of height may be associated with osteoarthritis for different reasons. Shorter bones and/or less cartilage may render the joints more susceptible to damage, while longer bones may produce greater levels of damaging stress on the joints.

The findings are exciting for several reasons, said Gonalo Abecasis, assistant professor in the School of Public Health. For one, there are many genes that control height, but only a few associated with osteoarthritis, he said.

"In this case the gene we picked also is important in osteoarthritis and it's actually quite hard to find genes for osteoarthritis," said Abecasis, who co-directed the study with Karen Mohlke of the University of North Carolina. "One of the things we were excited about is you could study (height) in many people, and once you've done that you have a short list of genes that you can then study for what they do in terms of osteoarthritis."

The findings also add to the general understanding of height.

"It is useful to know all genes responsible for height variation, so we are reassured if our baby is shorter than others because he has a collection of "short" alleles on his DNA, and not because he has something wrong, like a metabolism disorder," said Serena Sanna, co-author who worked on the paper as a post-doctoral student in Abecasis' group and who is now at the National Research Council di Cagliari in Italy. Anne Jackson, a research specialist at U-M, is also
'/>"/>

Contact: Laura Bailey
baileylm@umich.edu
734-647-1848
University of Michigan
Source:Eurekalert

Page: 1 2

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2015)... DUBLIN , May 26, 2015 ... has announced the addition of the "Saudi ... report to their offering. ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... Saudi Arabia is projected to grow ... This high growth is attributed to the surging ...
(Date:5/22/2015)... DALLAS , May 22, 2015 ... Recognition Market by Solution (2D, 3D, Thermal, Emotion, Forensic), by ... End User (Government and Utilities, Consumer and Home) - ... Market to grow from $2.77 Billion in 2015 to ... Browse 79 market data Tables and ...
(Date:5/20/2015)... DUBLIN , May 20, 2015 ... Markets ( http://www.researchandmarkets.com/research/h8t4x6/5year ) has announced the ... of the Global Iris Recognition Market" ... http://photos.prnewswire.com/prnh/20130307/600769) , ,This research service analyses ... across the government and commercial sectors, ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market Forecast and Opportunities, 2020 with Morpho Safran, ZK Technlogy, and Suprema Dominating 2Facial Recognition Market Worth $6.19 Billion by 2020 2Facial Recognition Market Worth $6.19 Billion by 2020 3Global Iris Recognition Market Report 2015 - 5-Year Opportunity Analysis 2
... F.L. MARCH 27, 2009 The founder of a ... genetic tests in making medical decisions is the 2009 ... for lifetime achievement in the field of genetic sciences. ... the University of Washington School of Medicine in Seattle, ...
... Scripps Research Institute has obtained the first glimpse of a ... cells. The protein, called P-glycoprotein or P-gp for short, is ... chemotherapy drugs. Understanding its structure may help scientists design more ... March 27, 2009, issue of the journal Science . ...
... new drug developed at the University of California, Davis ... II of human clinical trials to evaluate its efficacy. ... (s-EH) inhibitor, is "a first-in-class drug which may treat ... entomologist Bruce Hammock, who with UC Berkeley cell biologist ...
Cached Biology News:Roberta A. Pagon receives lifetime award in genetics from March of Dimes 2Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy 2Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy 3UC Davis bench-to-bedside research: Promising treatment in clinical trials 2UC Davis bench-to-bedside research: Promising treatment in clinical trials 3UC Davis bench-to-bedside research: Promising treatment in clinical trials 4UC Davis bench-to-bedside research: Promising treatment in clinical trials 5
(Date:5/29/2015)... 29, 2015 The changing healthcare landscape ... involving clinical development, regulatory compliance and market education. ... Medical Affairs has faced many challenges in creating ... And while its importance is recognized internally, Medical ... strong performance metrics to demonstrate the value of ...
(Date:5/29/2015)... , May 29, 2015 In recent years, ... availability of Big Data that can generate valuable insights. ... with utilizing Big Data have caused the biopharmaceutical sector ... industries. According to a recent study ... already have a Big Data team or function in ...
(Date:5/29/2015)... 29, 2015 BerGenBio AS ("BerGenBio" ... that an abstract on the latest data on BGB324, ... Axl receptor tyrosine kinase, and BGB10C9, an Axl function-blocking ... published in conjunction with the 2015 American Society of ... , May 29 - June 2, 2015. ...
(Date:5/29/2015)... (PRWEB) May 29, 2015 ... multi-drug-resistant organisms (MDROs), announced that initial feasibility data ... bacterial detection and susceptibility testing from positive blood ... on May 31, 2015 in New Orleans, LA. ... of molecular diagnostics that can quickly detect bacteria ...
Breaking Biology Technology:Creating an Effective Pharmaceutical Medical Affairs Group with Global Capabilities 2New Study Details Current & Future Big Data Trends Across Medical Affairs Functions 2BGB324 and BGB10C9 Show Promise in Models of Pancreatic Cancer 2BGB324 and BGB10C9 Show Promise in Models of Pancreatic Cancer 3Data Highlighting GeneWEAVE’s Smarticles™ Technology to be Presented at the 115th General Meeting of the American Society for Microbiology (asm2015) 2Data Highlighting GeneWEAVE’s Smarticles™ Technology to be Presented at the 115th General Meeting of the American Society for Microbiology (asm2015) 3
... a leader in forest tree improvement technologies, ... that are utilizing technology in-licensed from Senesco Technologies, Inc. ... companies had previously announced that trees that incorporate Senesco ... field trials. , , Selected trees from ...
... , , Data published in July 7, ... Academy of Sciences, , , QUEBEC CITY, July 7 ... TSX: AEZ), a global biopharmaceutical company focused on endocrine therapy ... journal, Proceedings of the National Academy of Sciences (PNAS), of ...
... , THE WOODLANDS, Texas, July 7 Lexicon ... biopharmaceutical company focused on discovering and developing breakthrough treatments for ... 2 clinical trial of LX1032 , the ... carcinoid syndrome . LX1032 is designed ...
Cached Biology Technology:ArborGen and Senesco Announce Wood Quality Results 2ArborGen and Senesco Announce Wood Quality Results 3ArborGen and Senesco Announce Wood Quality Results 4AEterna Zentaris: New Data Published on its Ghrelin Antagonist Compound, AEZS-123 (JMV2959), Supports its Use in Alcohol Addiction 2AEterna Zentaris: New Data Published on its Ghrelin Antagonist Compound, AEZS-123 (JMV2959), Supports its Use in Alcohol Addiction 3AEterna Zentaris: New Data Published on its Ghrelin Antagonist Compound, AEZS-123 (JMV2959), Supports its Use in Alcohol Addiction 4Lexicon Initiates Phase 2 Clinical Trial of LX1032 in Patients With Carcinoid Syndrome 2Lexicon Initiates Phase 2 Clinical Trial of LX1032 in Patients With Carcinoid Syndrome 3Lexicon Initiates Phase 2 Clinical Trial of LX1032 in Patients With Carcinoid Syndrome 4