A study of juvenile rat brain cells suggests that the effects of a commonly used anesthetic drug on the connections between brain cells are temporary.
The study, published in this week's issue of the journal PLOS ONE, was conducted by biologists at the University of California, San Diego and Weill Cornell Medical College in New York in response to concerns, arising from multiple studies on humans over the past decade, that exposing children to general anesthetics may increase their susceptibility to long-term cognitive and behavioral deficits, such as learning disabilities.
An estimated six million children, including 1.5 million infants, undergo surgery in the United States requiring general anesthesia each year and a least two large-scale clinical studies are now underway to determine the potential risks to children and adults.
"There is concern now about cognitive dysfunction from surgery and anesthesiahow much these effects are either permanent or slowly reversible is very controversial," said Hugh Hemmings, Jr., chair of anesthesiology at Weill Cornell and the study's other senior author. "It has been suggested recently that some of the effects of anesthesia may be more lasting than previously thought. It is not clear whether the residual effects after an operation are due to the surgery itself, or the hospitalization and attendant trauma, medications and stressor a combination of these issues."
The team of biologists examined one of the most commonly used general anesthetics, a derivative of ether called "isoflurane" used to maintain anesthesia during surgery.
"Previous studies in cultured neurons and in the intact brains of rodents provided evidence suggesting that exposure to anesthetics might render neurons more susceptible to cell death through a process called 'apoptosis'," said Halpain. "While overt cell death could certainly be one way to explain any long-lasting neurocognitive consequences of g
|Contact: Kim McDonald|
University of California - San Diego