Navigation Links
Study suggests different organ-derived stem cell injections improve heart function
Date:11/27/2012

Putnam Valley, NY. (Nov. 27, 2012) A study published in the current issue of Cell Transplantation (21:8), now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/, has found that when mesenchymal cells derived from skeletal muscle (SM-MSCs) or adipose tissue (ADSCs) were injected into the heart muscle (myocardium) of separate groups of laboratory rats that had suffered a myocardial infarction, rats in both groups experienced significantly improved left ventricle function and smaller infarct size after cell therapy.

The study, carried out by researchers at Oslo University Hospital and the Norwegian Center for Stem cell Research, Oslo University, sought to determine if MSCs from different organs would result in different functional outcomes.

"Despite advances in revascularization and medical therapy, acute myocardial infarction (AMI) and heart failure are still important causes of morbidity and mortality in industrialized countries," said study co-author Dr. Jan E. Brinchmann of the Norwegian center for Stem Cell Research at Oslo University Hospital, Oslo. "AMI leads to a permanent loss of contractile elements in the heart and the formation of fibrous scarring. Regeneration of contractile myocardium has been a target of cell therapy for more than a decade."

According to Dr. Brinchmann, MSCs tolerate hypoxia, secrete angiogenic factors and have been shown to improve vascularization; thus, they have properties suggesting that they may beneficially impact AMI, chronic heart failure and angina pectoris after cell transplantation. Following injection into the "border zone" and infarct area of immunodeficient rats one week after induced myocardial infarction, the researchers used echocardiography to measure myocardial function and other analyses to measure the size of scaring, density of blood vessels in the scar, and the health of myocardial tissues.

"Our results showed that intramyocardial injection of both ADSCs and SM-MSCs one week after AMI led to a substantial decrease in infarct size and a significant improvement in left ventricle function when compared with injections of cell culture medium alone," concluded the authors. "There was a trend toward better functional improvement in the SM-MSC group when compared to the ADSC group, but this did not reach significance."

They concluded that many questions remain unanswered, including the question of whether MSCs isolated from different organisms could result in different functional outcomes. Other unanswered questions relate to the optimal time delay between the onset of myocardial infarction and injection of MSCs. These cells do, however, still appear to be "a potentially interesting adjuvant treatment modality for selected patients following acute myocardial infarction," they concluded.


'/>"/>

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. Study advances use of stem cells in personalized medicine
2. University of Maryland School of Medicine, NIH study pinpoints brain areas role in learning
3. Algae Biomass Organization hails new UCSD study showing saltwater algae viable for biofuels
4. Study reveals the proteins expressed by human cytomegalovirus
5. New public gut bacteria study expected to reach around world
6. Researchers study links between conflict and fisheries in East Africa
7. NJIT civil engineer receives NSF grant to study storms impact on Jersey Shore
8. New whale shark study used metabolomics to help understand shark and ray health
9. NIST study suggests carbon nanotubes may protect DNA from oxidation
10. New study finds milk-drinking kids reap physical benefits later in life
11. New brain gene gives us edge over apes, study suggests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... May 16, 2017  Veratad Technologies, LLC ( www.veratad.com ... age and identity verification solutions, announced today they will ... 2017, May 15 thru May 17, 2017, in ... International Trade Center. Identity impacts the ... in today,s quickly evolving digital world, defining identity is ...
(Date:4/19/2017)... 19, 2017 The global military ... is marked by the presence of several large global ... by five major players - 3M Cogent, NEC Corporation, ... for nearly 61% of the global military biometric market ... the global military biometrics market boast global presence, which ...
(Date:4/13/2017)... , April 13, 2017 According to a ... Identity Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment ... the IAM Market is expected to grow from USD 14.30 Billion in ... Rate (CAGR) of 17.3%. ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:9/25/2017)... , ... September 25, 2017 , ... ... and cloud based products for clinical data optimization announced today that the ... the Society of Clinical Data Management (SCDM) NextGen Technology Innovation Awards . ...
(Date:9/25/2017)... , ... September 25, 2017 , ... ... tablets and mobile payment devices, announced that they have been successfully integrated with ... Colombia, which enables the commercial deployment in the region. , Bluebird biometric ...
(Date:9/25/2017)... ... September 25, 2017 , ... ... a third-party auditor, MindFlow Design has been found to provide product development ... or Fortune 500 companies, our clients have a lot at stake ...
(Date:9/22/2017)... (PRWEB) , ... September 22, 2017 , ... ... announced it will host a booth at premier packaging event PACK EXPO International ... by the Packaging Machinery Manufacturers Institute (PMMI). , At this year’s PACK EXPO ...
Breaking Biology Technology: