Navigation Links
Study shows the HPV vaccine Gardasil doesn't increase disease activity in SLE patients
Date:5/26/2011

Results of a Chinese study showed that the HPV vaccine did not have significant effects on the number of disease flares or antibody measures in patients with inactive SLE receiving stable doses of medications after administration, and therefore was determined safe to use to prevent HPV in this group of patients. SLE, an autoimmune disorder, affects nine times as many women as men1 and studies have shown that the rate of HPV in this group is significantly higher than in the healthy population.2 Vaccination is therefore an important consideration in protecting SLE patients from HPV infection, which has been shown to be responsible for cervical cancer.

"Our study set out to investigate whether vaccination with Gardasil increased disease flares in patients with SLE," said Professor Chi Chiu Mok from the Tuen Mun Hospital, Hong Kong. "The causal relationship between vaccination and flare wasn't clear, however what we do know is that the rate of flares was not increased post vaccination, confirming that, in the cohort studied, Gardasil was safe for use."

In the duration of the six-month study, there were three mild/moderate mucocutaneous flares (flares that occur in mucous-lined areas of the body), which were all controlled with usual treatment regimens. The rate of flare-ups observed in this study (rate: 0.08/patient/year) was numerically lower than the rate observed in a cohort of SLE patients observed over a 5 year period (0.10/patient/year) though the reason for this is unknown.

Furthermore there were no significant changes in the levels of various antibody measures used to assess level of disease activity. Disease flares (measured by the Systemic Lupus Erythematosus National Assessment (SELENA) flare instrument), disease activity scores (measured by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)) and physicians' global assessment (PGA) scores were also the same from baseline to two and six months.

Female patients who fulfilled four ACR criteria for SLE were recruited for the study. The 50 women were between the ages of 18 and 35 (mean age 25.8 3.9 years) and had received a stable dose of prednisolone and/or other immunosuppressives (the normal treatment for patients with SLE) within three months of the study. The Gardasil vaccine was given at baseline, two months and six months by intramuscular injection, and various disease scores and antibody measures were recorded and analysed.


'/>"/>

Contact: Rory Berrie
eularpressoffice@uk.cohnwolfe.com
44-790-151-3297
European League Against Rheumatism
Source:Eurekalert

Related biology news :

1. Long-term study shows effect of climate change on animal diversity
2. £2 million study to reveal workings of dementia genes
3. New study looks to define evangelicals and how they affect polling
4. CU-Boulder study suggests air quality regulations miss key pollutants
5. Researchers study acoustic communication in deep-sea fish
6. Study reveals homeowner perceptions in fire-prone areas
7. Researchers study how pistachios may improve heart health
8. Study: urban black bears live fast, die young
9. New study indicates link between weight gains during pregnancy and dieting history
10. Study reveals specific gene in adolescent men with delinquent peers
11. Sweat it out: UH study examines ability of sweat patches to monitor bone loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... India , April 28, 2016 ... Infosys (NYSE: INFY ), and Samsung SDS, a ... that will provide end customers with a more secure, ... services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ) , ... services, but it also plays a fundamental part in enabling ...
(Date:4/26/2016)... LONDON , April 26, 2016 ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... a partnership to integrate the Onegini mobile security ... (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The ... enhanced security to access and transact across channels. ...
(Date:4/19/2016)... April 20, 2016 The new ... a compact web-based "all-in-one" system solution for all door ... reader or the door interface with integration authorization management ... control systems. The minimal dimensions of the access control ... the building installations offer considerable freedom of design with ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... ... Amgen, will join the faculty of the University of North Carolina Kenan-Flagler ... of strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s ...
(Date:6/24/2016)... on a range of subjects including policies, debt and investment ... Speaking at a lecture to the Canadian Economics ... the country,s inflation target, which is set by both the ... "In certain areas there needs to be frequent ... not sit down and address strategy together?" He ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Researchers at the ... commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the subject ... it now. , Diagnostic biomarkers are signposts in the blood, lung fluid or ...
(Date:6/23/2016)... Mass. , June 23, 2016   ... development of novel compounds designed to target cancer ... napabucasin, has been granted Orphan Drug Designation from ... the treatment of gastric cancer, including gastroesophageal junction ... stemness inhibitor designed to inhibit cancer stemness pathways ...
Breaking Biology Technology: