Navigation Links
Study shows the HPV vaccine Gardasil doesn't increase disease activity in SLE patients
Date:5/26/2011

Results of a Chinese study showed that the HPV vaccine did not have significant effects on the number of disease flares or antibody measures in patients with inactive SLE receiving stable doses of medications after administration, and therefore was determined safe to use to prevent HPV in this group of patients. SLE, an autoimmune disorder, affects nine times as many women as men1 and studies have shown that the rate of HPV in this group is significantly higher than in the healthy population.2 Vaccination is therefore an important consideration in protecting SLE patients from HPV infection, which has been shown to be responsible for cervical cancer.

"Our study set out to investigate whether vaccination with Gardasil increased disease flares in patients with SLE," said Professor Chi Chiu Mok from the Tuen Mun Hospital, Hong Kong. "The causal relationship between vaccination and flare wasn't clear, however what we do know is that the rate of flares was not increased post vaccination, confirming that, in the cohort studied, Gardasil was safe for use."

In the duration of the six-month study, there were three mild/moderate mucocutaneous flares (flares that occur in mucous-lined areas of the body), which were all controlled with usual treatment regimens. The rate of flare-ups observed in this study (rate: 0.08/patient/year) was numerically lower than the rate observed in a cohort of SLE patients observed over a 5 year period (0.10/patient/year) though the reason for this is unknown.

Furthermore there were no significant changes in the levels of various antibody measures used to assess level of disease activity. Disease flares (measured by the Systemic Lupus Erythematosus National Assessment (SELENA) flare instrument), disease activity scores (measured by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)) and physicians' global assessment (PGA) scores were also the same from baseline to two and six months.

Female patients who fulfilled four ACR criteria for SLE were recruited for the study. The 50 women were between the ages of 18 and 35 (mean age 25.8 3.9 years) and had received a stable dose of prednisolone and/or other immunosuppressives (the normal treatment for patients with SLE) within three months of the study. The Gardasil vaccine was given at baseline, two months and six months by intramuscular injection, and various disease scores and antibody measures were recorded and analysed.


'/>"/>

Contact: Rory Berrie
eularpressoffice@uk.cohnwolfe.com
44-790-151-3297
European League Against Rheumatism
Source:Eurekalert

Related biology news :

1. Long-term study shows effect of climate change on animal diversity
2. £2 million study to reveal workings of dementia genes
3. New study looks to define evangelicals and how they affect polling
4. CU-Boulder study suggests air quality regulations miss key pollutants
5. Researchers study acoustic communication in deep-sea fish
6. Study reveals homeowner perceptions in fire-prone areas
7. Researchers study how pistachios may improve heart health
8. Study: urban black bears live fast, die young
9. New study indicates link between weight gains during pregnancy and dieting history
10. Study reveals specific gene in adolescent men with delinquent peers
11. Sweat it out: UH study examines ability of sweat patches to monitor bone loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/16/2017)... March 16, 2017 CeBIT 2017 - Against identity fraud with DERMALOG ... ... Used combined in one project, multi-biometric solutions provide a crucial contribution ... Used combined in one ... ...
(Date:3/9/2017)... , Australia , March 9, ... study data at the prestigious World Lung Imaging Workshop ... Andreas Fouras , was invited to deliver the ... pulmonary medicine. This globally recognised event brings together leaders ... share the latest developments in lung imaging. ...
(Date:3/7/2017)... -- Brandwatch , the leading social intelligence company, today announces ... to uncover insights to support its reporting, help direct future campaigns, ... leading youth charity will be using Brandwatch Analytics social listening and ... understanding of the topics and issues that are a priority for ... "Until ...
Breaking Biology News(10 mins):
(Date:3/30/2017)... , March 30, 2017  Jazz Pharmaceuticals plc (Nasdaq: ... entered into license agreements with Nippon Shinyaku, Co., Ltd. ... (cytarabine and daunorubicin liposome injection), or CPX-351, in ... terms of the agreements, Nippon Shinyaku will receive exclusive ... Japan in return for an ...
(Date:3/29/2017)... ... March 29, 2017 , ... The ... to finding cures for inflammatory bowel diseases (IBD), and ReachMD , the ... exclusive content to ReachMD learners. , The partnership, which launched in the ...
(Date:3/29/2017)... "Surging application of gesture control features in ... expected to drive the growth of gesture recognition and ... is expected to be worth USD 18.98 billion by ... and 2022. The touchless sensing market is expected to ... a CAGR of 17.44% between 2017 and 2022. Gesture ...
(Date:3/29/2017)... ... March 29, 2017 , ... (March 29, ... Mexico has been approved as an active member of the Mexican Direct ... among distributers and consumers in relationship marketing. This professional organization fosters loyal and ...
Breaking Biology Technology: