Navigation Links
Study shows potential for using algae to produce human therapeutic proteins
Date:3/8/2010

n from algae and, last year, demonstrated success producing a human antibody. Both of these proteins had biological activities similar to the real proteins from mammalian cells.

"That was the proof of concept," said Mayfield. "It showed us that the system worksthat we could produce complex mammalian proteins in algae. What we did in this next study was to say, 'Let's take seven diverse human therapeutic proteins and see if we can express them in algae and report the good and the bad.'"

The scientists found that in algae they were able to produce VEGF, HMGB1 and domain 14 of human fibronectin at levels above one percent of total soluble protein, levels sufficient for easy purification. Domain 10 of human fibronectin could also be produced from algae at these levels when fused to the protein M-SAA, which they had previously used to increase the accumulation of other proteins. Human proinsulin could be produced by algae, but only at lower levels, the study showed, while human interferon β1 and EPO were not produced by algae.

"What our results show is that algae are a robust platform for the production of human therapeutic proteins," said Mayfield. "While not every protein can be produced in algae, a good fraction can, just like in any other system. You can get expression of about 25 percent in bacteria and about 40 to 50 percent in mammalian cells, so we're in the same ball park as these other systems."

What makes algae particularly attractive compared to bacterial and mammalian systems, the scientists say, is its ability to produce proteins cheaply and at very large scale. With algae currently being produced at about $3 per kilogram at commercial scale, the researchers estimate that making recombinant protein would cost about 60 cents per gram prior to purification.

"This is about the same cost estimates for the least expensive protein expression systems presently available, and considerably cheaper than mammalian cell
'/>"/>

Contact: Kim McDonald
scinews@ucsd.edu
858-534-7572
University of California - San Diego
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study shows potential for using algae to produce human therapeutic proteins
(Date:4/2/2015)... HAMBURG, Germany , April 2, 2015 /PRNewswire/ ... ten fingerprint tests DERMALOG by far outperforms the ... While always maintaining high accuracy, the system is ... second. Hence, the speed proves up to be ... 40% faster than its runner-up performance. ...
(Date:4/2/2015)... GOTHENBURG, Sweden , April 2, 2015 ... for its touch fingerprint sensor FPC1025 from the distributor ... Deliveries will commence during Q2 2015 although the major ... 2015. The sensors will be used by smartphone manufacturers ... of 110 MSEK is included in the communicated revenue ...
(Date:3/31/2015)... -- Elephant Talk Communications Corp. (NYSE MKT: ETAK) ("Elephant Talk" ... Network Architecture (ET Software DNA® 2.0) platforms and cyber ... million for the year ended December 31, 2014 as ... ended December 31, 2013. At the ... multi-year transition away from its legacy landline business to ...
Breaking Biology News(10 mins):DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6
... scientists has discovered extensive similarities between a strain of ... to opportunistic infections in hospital patients. The findings suggest ... a range of biotech applications. The genetic analysis was ... (DOE) Brookhaven National Laboratory, and will be published in ...
... at the University of North Carolina at Chapel Hill ... the understanding of cellular aging. They found that ... key protein, called p16INK4a, dramatically increases in most mammalian ... cancer researchers are interested in its role in cellular ...
... found what they think is a critical and, until ... causes sexual dysfunction and infertility. Scientists know that ... as cortisol - that inhibit the body,s main sex ... count, ovulation and sexual activity. The new research ...
Cached Biology News:Plant microbe shares features with drug-resistant pathogen 2Plant microbe shares features with drug-resistant pathogen 3Test detects molecular marker of aging in humans 2Stress puts double whammy on reproductive system, fertility 2Stress puts double whammy on reproductive system, fertility 3
(Date:5/5/2015)... , May 5, 2015  Orexigen Therapeutics, Inc. ... the first quarter 2015 on Friday, May 8 before ... a live webcast and conference call at 8:30 a.m. ... live call may be accessed by phone by calling ... 39586962. The webcast can be accessed live on the ...
(Date:5/5/2015)... 5, 2015  Indianapolis-based medical device manufacturer NICO ... line of products including the BrainPath® and Myriad™ ... deep-seated brain abnormalities and then removing affected tissue. ... more than 50 institutions throughout the ... been included in 12 abstracts, three peer-reviewed publications, ...
(Date:5/4/2015)... SAN FRANCISCO, Calif. , May 4, 2015 ... clinical-stage biopharmaceutical company focused on the development and ... diseases, announced today the completion of its merger ... 4). In conjunction with the closing of the ... from a combination of new investors and all ...
(Date:5/4/2015)...  Tikcro Technologies Ltd. (OTCQB: TIKRF) announced today that ... for the fiscal year ended December 31, 2014 with ... report on Form 20-F contains information regarding its biotechnology ... of cancer immune checkpoints. This project aims to develop ... binding in targeting certain identified immune checkpoints. The filing ...
Breaking Biology Technology:NICO Corporation Gains Market Expansion after Multiple Published Clinical Articles Support Access Technology for Deep Brain Lesions 2NICO Corporation Gains Market Expansion after Multiple Published Clinical Articles Support Access Technology for Deep Brain Lesions 3Tobira Therapeutics Completes Financing and Merger with Regado Biosciences 2Tobira Therapeutics Completes Financing and Merger with Regado Biosciences 3Tobira Therapeutics Completes Financing and Merger with Regado Biosciences 4Tobira Therapeutics Completes Financing and Merger with Regado Biosciences 5Tobira Therapeutics Completes Financing and Merger with Regado Biosciences 6Tikcro Technologies Files Annual Report on Form 20-F for the Year Ended December 31, 2014 2
... CRANBURY, N.J., Sept. 12 Amicus Therapeutics,(Nasdaq: FOLD ... Officer, will present a corporate update at the Merrill ... United,Kingdom on Tuesday, September 18th at 4:00 pm BDT ... A live audio web cast of the presentation will ...
... MORRISVILLE, N.C., Sept. 12 AVOS Life Sciences,announced ... Vice President. His,primary responsibility will be providing advisory ... areas as well as selected investment,assignments in capital ... he will also have responsibility for AVOS, emerging ...
... Robotic-Assisted Coronary ... Artery Bypass Surgery, REDWOOD CITY, Calif., ... it has received European CE Mark,(Conformite Europeenne) approval for the C-Port(R) ... of Cardica,s C-Port(R) xA,Distal Anastomosis System product line and further facilitates ...
Cached Biology Technology:Amicus Therapeutics to Present at the Merrill Lynch Global Pharmaceutical, Biotech & Medtech 2007 Conference 2Amicus Therapeutics to Present at the Merrill Lynch Global Pharmaceutical, Biotech & Medtech 2007 Conference 3Senior Research Analyst Richard Evans Joins AVOS Life Sciences 2Cardica Receives European CE Mark for C-Port Flex A System for Use in Coronary Artery Bypass Surgery 2Cardica Receives European CE Mark for C-Port Flex A System for Use in Coronary Artery Bypass Surgery 3
... Oven with circular clear acrylic chamber for ... HybriCycler Oven features microprocessor operation for precise ... the unit., Carousel rotates at 11 ... ,easily removable , Bottle Capacity - ...
... HB-500 Minidizer is a personal desktop unit ideal ... space requirements. , Rotation speed set at ... to 80o C , Bottle capacity of ... or 15 ml conical ,plastic bottles , ...
... KingFisher magnetic particle based purification systems provide ... from any sample. They offer increased throughput ... three systems- KingFisher, KingFisher mL and KingFisher ... 1000 l. Each system consists of an ...
... The DNA120OP is specifically engineered for efficient ... design incorporates a glass cover and a ... automated, unattended, odor-free processing of samples in ... for Synthetic Oligos ...
Biology Products: