Patients were divided into two groups and instructed to follow a healthier lifestyle with dietary improvements, moderate exercise and effective management of health risk factors. Both groups were treated with anti-hypertensive medication Ramipril, taking a standard dosage of 5 mg twice a day, with one group of 31 patients taking Pycnogenol in addition to the medication.
In the group taking Pycnogenol, 50 mg Pycnogenol tablets were taken three times a day at approximately 8 a.m., 4 p.m. and 10 p.m., a total dosage of 150 mg of Pycnogenol per day. Urine was collected during a 24 hour period for quantification of the protein albumin in the urine at baseline and again after six months of treatment. Fasting blood was drawn for standard blood analysis. Systolic and diastolic blood pressure and heart rate were monitored in the morning.
The study also shows Pycnogenol is effective for improving blood pressure in patients with metabolic syndrome. The study found that taking Pycnogenol as an adjunct to Ramipril significantly further lowered systolic and diastolic blood pressure as compared to the group taking Ramipril alone. While average blood pressure in the Ramipril group was lowered to borderline-high 128.2/90.2 mmHg, the values in the group taking Pycnogenol with Ramipril reached essentially normal values (122.2/85.3 mmHg) after six months of treatment.
Kidney function improved in both groups as judged by a significant reduction of protein detected in collected urine. With Ramipril alone, urinary protein decreased by 22 percent and with the addition of Pycnogenol it decreased by 52.7 percent. Further, the group taking Pycnogenol had a lowered fasting blood glucose level, which was reduced from high average value 135.6 mg/dL at baseline to reach essentially healthy reference value 102.3 mg/dL after six mon
|Contact: Katherine Davis|