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Study shows nearly 1/3 of human genome is involved in gingivitis
Date:12/7/2009

Dentistry-based Center for Oral and Systemic Diseases. "Understanding the thousands of individual genes and multiple systems involved in gingivitis will help explain exactly what is occurring in a person's body at the onset of the disease and how it relates to their overall health."

The build-up of plaque formed during the onset of gingivitis represents the overgrowth of bacteria as a biofilm on the teeth above and below the gum line. Biofilms can form in other parts of the body and are known to be involved with health conditions, such as urinary tract infections, ear infections and chronic sinusitis. Researchers believe learning about how the body interacts with bacteria overgrowth during gingivitis could provide insight into a variety of bio-film-associated diseases.

"Data generated by the study will be crucial in developing new approaches to treating gingivitis," said Leslie Winston, D.D.S., Ph.D., co-author of the study and Director of Professional and Scientific Relations at P&G Oral Care (makers of Crest and Oral-B). "We plan to conduct additional research to identify biomarkers of gum disease in at risk individuals and hope that this will lead to new and more advanced treatment options and preventative measures."

About the Study

The objective of this study was to understand gingivitis on a molecular level by identifying changes in gene expression taking place in the mouth during gingivitis onset and the healing process. Fourteen healthy individuals with mild gingivitis participated in the study. After baseline tooth cleanings, gingivitis was induced in each study participant, followed by the participants adhering to an oral hygiene regimen of twice-daily brushing and regular flossing. Gum tissue was collected at baseline, four weeks after the induction of gingivitis and one week after resuming the oral hygiene regimen of brushing and flossing.

Gene expression data was analyzed using gene chip technology that
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Contact: Liz Bryan
lbryan@spectrumscience.com
202-955-6222
Spectrum
Source:Eurekalert

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