Navigation Links
Study shows moms may pass effects of stress to offspring via vaginal bacteria and placenta
Date:11/11/2013

l disorders."

In a parallel animal study, Bale and colleagues were looking for predictive biomarkers of maternal stress and found that a specific protein in the placenta, OGT, may have implications for brain development in offspring. The single enzyme is known as O-linked-N-acetylglucosamine transferase or "OGT," which is important in a wide variety of regulatory functions, including development.

The researchers found that placentas associated with male mouse pups had lower levels of OGT than the placentas associated with female pups, and levels of OGT in the placenta were even lower when their moms were stressed.

The team then used transgenics to directly manipulate placental OGT levels similar to the effect that maternal stress has. That way, they could ask if any of the effects of mom's stress on brain development and function were related to this placental gene. What they found was fascinating--when these babies became adults, they were smaller and more sensitive to stress, very similar to the offspring from the stressed moms.

"Since lower levels were associated with stress, these results suggest that placental OGT may provide a protective role during pregnancy," said Bale. "These data also suggest that OGT may serve as a biomarker for a range of neurodevelopmental disorders in children, as we have previously shown similar regulation of this gene in human placental tissue."


'/>"/>

Contact: Steve Graff
stephen.graff@uphs.upenn.edu
215-349-5653
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/25/2015)... CITY and BELLEVUE, Wash. ... leader in advanced robotic systems, announced today it will ... unmanned ground vehicle (UGV), at the National Tactical Officers ... The Guardian S is the first-ever ... culmination of years of research and in-field trials and ...
(Date:8/20/2015)... Calif. , Aug. 20, 2015   ... focused on improving the user experience and security ... vision technologies, today announced that its TrulySecure™ ... biometric authentication software to be FIDO Certified™. ... TrulySecure for compliance with the FIDO UAF (Universal ...
(Date:8/18/2015)... DUBLIN , Aug. 17, 2015 ... the addition of the "Global Biometric Authentication ... Application - Estimation & Forecast, 2015-2020" report ... biometric authentication and identification systems market is expected ... from 2015 to 2020 and generate over $25 ...
Breaking Biology News(10 mins):Sarcos to Debut First-of-its-Kind Snake Robot 2Sarcos to Debut First-of-its-Kind Snake Robot 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 2TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 4TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 5Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2
... August 8th, 2011, Shenzhen, China BGI, the world,s ... Second People,s Hospital, announced today that the study on ... carcinoma (TCC) of the bladder was published online in ... genetic basis for future studies on TCC, suggesting that ...
... new window to understanding how the ocean impacts climate change. ... College, spent four years collecting samples from floating sediment traps ... giving scientists a peek at how much carbon is locked ... Collins, research suggests that the majority of particulate organic carbon ...
... GTSI Corp. (NASDAQ: GTSI ), a ... local governments, announced today the award of the Biometric ... contract will provide war fighters mobile biometric devices to ... the field. The contract has a total value of ...
Cached Biology News:Research discovers frequent mutations of chromatin remodeling genes in TCC of the bladder 2Ocean probes to help refine climate change forecasting 2GTSI Wins Department of Defense Contract to Provide Biometric Automated Toolset Systems for U.S. Army 2
(Date:8/27/2015)... The National Necrotizing Fasciitis Foundation ... by doctors at Vanderbilt University Hospital in ... and Dr. John Crew , director of the ... Center in Daly City, CA. ... pioneered by Dr. Crew, that had previously saved the ...
(Date:8/27/2015)... ... August 27, 2015 , ... Inc. Magazine released its annual list of the ... 1,361 in growth for the three years through 2014. Being named to the Inc. ... organizations in the country. , “We are thrilled to make the Inc. 5000 ...
(Date:8/26/2015)... - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ICO) ... quarter ended June 30, 2015. Amounts, unless specified ... under International Financial Reporting Standards ("IFRS"). ... Oral Amp B program, rapidly advancing towards the ... Rae , President & CEO of iCo Therapeutics. "We ...
(Date:8/26/2015)... 2015 Intrexon Corporation (NYSE: XON ), ... of its previously announced public offering of common stock, ... their option to purchase an additional 731,707 shares of ... per share.  The exercise of the underwriters, option brought ... by Intrexon to 5,609,756 shares and increased the total ...
Breaking Biology Technology:Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 2Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 3iLab Solutions Named to 2015 Inc. 5000 List 2iLab Solutions Named to 2015 Inc. 5000 List 3iCo Therapeutics Announces Second Quarter 2015 Financial Results 2iCo Therapeutics Announces Second Quarter 2015 Financial Results 3Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 2Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 3Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 4
... AOL begin charging marketers to reach the inboxes of their ... inbox. One cent? 1/4 cent? , ,The right inbox? ... obstacle for most consumers. It's not uncommon for inboxes to ... to ten percent are either welcomed or relevant. Most consumers ...
... In other circumstances, it might not seem ... software for human resources and payroll systems, but in ... weeks ago the state Department of Administration was taking ... director of the Legislative Fiscal Bureau and state auditor, ...
... passed muster in the first round of the Governor's ... were chosen from 188 submissions by a panel of ... represent various municipalities, with concentrations in the Madison and ... year and 330 in 2004, the first contest. But ...
Cached Biology Technology:What's an inbox worth? 2What's an inbox worth? 3What's an inbox worth? 4State defensive on new Oracle contract 2
... be upgraded to the GenePix Autoloader 4200AL. ... and saves results for up to 36 ... the batch is complete. Line-by-line autofocus ensures ... GenePix Pro gives you complete flexibility to ...
... Maximize the value of your microarray ... the support you need from consultation to ... to date methods. Utilize our expertise in ... or from your own microarray experiments., ,Normalization ...
... the value of your microarray data ... the support you need from consultation ... most up to date methods. Utilize ... Gene Expression Profiling Service or from ...
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. Material: ...
Biology Products: