Navigation Links
Study shows long-term effects of radiation in pediatric cancer patients
Date:8/21/2012

For many pediatric cancer patients, total body irradiation (TBI) is a necessary part of treatment during bone marrow transplant it's a key component of long term survival. But lengthened survival creates the ability to notice long term effects of radiation as these youngest cancer patients age. A University of Colorado Cancer Center study recently published in the journal Pediatric Blood & Cancer details these late effects of radiation.

"These kids basically lie on a table and truly do get radiation from head to toe. There is a little blocking of the lungs, but nothing of, for example, the brain or the kidneys," says Jean Mulcahy-Levy, MD, research fellow at the CU Cancer Center and the paper's first author.

Of 15 patients who received TBI before age 3, many developed endocrine and metabolic problems including testicular malfunction (78 percent), restrictive pulmonary disease due to high levels of blood triglycerides (74 percent), and cataracts (78 percent). Likewise, 90 percent of patients showed abnormally low levels of growth hormone, and 71 percent were considerably under height. Additional late effects of TBI included kidney, liver, skeletal and cardiac malfunction and three of four patients whose IQ had been tested before TBI showed cognitive decline.

"Fifteen doesn't seem like a large number, but because we have such a good pediatric bone marrow transplant program here at Children's Hospital Colorado and radiation therapy program at the CU Cancer Center, we were able to get a large enough cohort of patients to see these overall effects," Mulcahy-Levy says.

The study supports the recommendations of the Children's Oncology Group for long term follow up care for children receiving TBI (survivorshipguidelines.org). Specifically, Mulcahy-Levy hopes that increasing awareness of likely effects will help patients and their doctors screen for, detect, and correct likely effects of TBI.

"It's not so much that you want to stop TBI, which is frequently a necessary part of treatment, but this study shows it's important know about these problems in order to address them appropriately and proactively," Mulcahy-Levy says.


'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Related biology news :

1. Organic study of live pancreatic tissue yields new opportunities for diabetes research
2. Turmeric spices up virus study
3. Bird louse study shows how evolution sometimes repeats itself
4. Study proves that 1 extinction leads to another
5. NIH backs Rice University study of delay in gene transcription networks
6. Study of fruit fly chromosomes improves understanding of evolution and fertility
7. Selfish DNA in animal mitochondria offers possible tool to study aging
8. UIC study examines exercise and weight loss for older adults with osteoarthritis
9. Eating grapes may help protect heart health in men with metabolic syndrome, new study suggests
10. Carnegie Mellon study shows skin-aging radicals age naturally formed particles in the air
11. New UC Santa Barbara-based project to study contaminants in urban water environment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/12/2017)...  Trovagene, Inc. (NASDAQ: TROV ), a ... that it has signed agreements with seven strategic partners ... Middle East for commercialization of the ... wave of international distribution agreements for Trovagene,s CLIA based ... The initial partners will introduce Trovagene,s liquid biopsy ...
(Date:1/11/2017)... -- Michael Johnson, co-founder of Visikol Inc. a company originally funded with ... to the elite "Forbes 30 Under 30" list in the Science ... 20 fields nationwide to be recognized as a leader in business ... ... a PhD candidate at Rutgers University. Visikol ...
(Date:1/4/2017)... thousands of attendees at this year,s International Consumer Electronics Show (CES), ... devices and services, will be featuring its new line of ULTRA CONNECT ... special CES Exhibit Suite , the new upper arm and wrist smart ... product platform.  Continue Reading ... ...
Breaking Biology News(10 mins):
(Date:1/11/2017)... ... January 11, 2017 , ... ... Research show early promise of the investigational anti-cancer agent tucatinib (formerly ONT-380) against ... previous treatment regimens. Twenty-seven percent of these heavily pretreated patients saw clinical benefit ...
(Date:1/11/2017)... , ... January 11, 2017 , ... ... year and costing healthcare systems more than $23.7 billion, healthcare systems are ... , Among the most common sepsis-causing pathogens are bacteria and the yeast ...
(Date:1/11/2017)... ... 11, 2017 , ... Symbios Technologies, Inc., a ... Science Foundation (NSF) has awarded Symbios a Small Business Innovation Research (SBIR) ... the Symbios Tubular Plasma Reactor™ (TPR™) by scaling the system for first customer ...
(Date:1/11/2017)... 11, 2017  GenVec, Inc. (NASDAQ: ... today that its chief scientific officer, Douglas ...  "AdenoVerse™ platform for translational development of innovative gene ... the upcoming Phacilitate Cell & Gene Therapy World ... Florida.  Dr. Brough,s presentation will highlight the utility ...
Breaking Biology Technology: