Navigation Links
Study shows extreme form of pregnancy-related morning sickness could be genetic
Date:11/5/2010

Approximately 60,000 pregnant women are hospitalized each year due to hyperemesis gravidarum (HG), an extreme form of nausea and vomiting that endangers their lives and often forces them to reluctantly terminate their pregnancies.

And for women with sisters, mothers and grandmothers on either side of the family who have experienced extreme morning sickness during pregnancy, the risk of HG may be heightened, according to a new study led by researchers from UCLA and the University of Southern California.

Researchers traced both the maternal and paternal family histories of women with HG and found not only that the condition could be genetic but that women with sisters who had HG could have a more than 17-fold risk of experiencing the debilitating condition too.

The findings are published online in the American Journal of Obstetrics and Gynecology.

"Pregnant women with a family history of extreme nausea in pregnancy should be aware that they may have it too, and health care providers should take a family history of nausea in pregnancy at the first visit with an obstetrician," said lead author Marlena Fejzo, an assistant professor of hematologyoncology at the David Geffen School of Medicine at UCLA and an assistant professor of maternal and fetal medicine at Keck School of Medicine of USC. "The high familial prevalence strongly suggests a genetic component to this condition."

Researchers surveyed about 650 participants for the joint study on the genetics and epidemiology of HG. Women who had been diagnosed with HG and treated with IV fluids were asked to recruit, as a control, a friend who had at least two pregnancies lasting more than 27 weeks and who had not had HG. The researchers then compared the family histories of extreme nausea in the women with HG with those of the controls. Of the 650 participants, 207 women with HG and 110 controls had at least one sister who had been pregnant.

The researchers found that women with HG were more than five times as likely as the controls to report having a sister with severe morning sickness or HG. When including sisters who had experienced HG and excluding sisters with just severe morning sickness study participants with HG had 17.3 times the odds of also having the condition. In addition, 33 percent of the women with HG reported having an affected mother, compared with only 8 percent of the controls.

Among the women who had information regarding their grandmothers' pregnancies, 18 percent of those with HG had a maternal grandmother with HG, and 23 percent had a paternal grandmother affected by the condition, suggesting that it can be passed on through the women's fathers.

The authors noted that their findings could be limited by factors such as having used the Internet to survey the participants and the fact that the family histories were based on self-reports, which can lead to misclassification.

"Because the incidence of hyperemesis gravidarum is most commonly reported to be 0.5 percent in the population, and the sisters of cases have as much as an 18-fold increased familial risk for HG compared to controls, this study provides strong evidence for a genetic component to extreme nausea and vomiting in pregnancy," the authors conclude.

Previous studies have used hospitalization, clinical and other records to examine the prevalence of this mysterious condition among various population sets. One looked at pregnancy nausea medication in identical twins, compared with fraternal twins, and another focused on mother-to-daughter recurrence. Overall, the prior studies also suggested that genetics are involved.


'/>"/>

Contact: Enrique Rivero
erivero@mednet.ucla.edu
310-794-2273
University of California - Los Angeles
Source:Eurekalert

Related biology news :

1. Motor Neurone Disease Association study identifies MND biomarker
2. LSU researcher participates in NIH-funded study ushering in the age of personal genomics
3. Study shows a single shot of morphine has long lasting effects on testosterone levels
4. Study shows how ancient plants and soil fungi turned the Earth green
5. UMass Medical School study points to genetic link in apnea of prematurity
6. First peer-reviewed study finds BPA levels in US foods 1,000 times less than limits
7. Study provides treatment hope for long term effects of brain trauma
8. Successful mothers get help from their friends: Dolphin study
9. Grasses have potential as alternate ethanol crop, Illinois study finds
10. Study improves accuracy of models for predicting ozone levels in urban areas
11. Study finds fat hormones long-sought link to heart protection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2017)... public,s help is being enlisted in what,s thought to be the biggest ... human body –and are believed to affect health.  ... The Microbiome Immunity Project is the largest study to date ... project's goal is to help advance scientific knowledge of the role of ... The ...
(Date:6/23/2017)... N.Y. and ITHACA, N.Y. ... ) and Cornell University, a leader in dairy research, ... with bioinformatics designed to help reduce the chances that ... With the onset of this dairy project, Cornell University ... Consortium for Sequencing the Food Supply Chain, a food ...
(Date:5/16/2017)... , May 16, 2017   Bridge ... health organizations, and MD EMR Systems , ... development partner for GE, have established a partnership ... Portal product and the GE Centricity™ products, including ... EMR. These new integrations will ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... For the second time in ... STEM Mentoring Award. Representatives of the FirstHand program travelled to Washington, D.C. Tuesday, ... , US2020’s mission is to change the trajectory of STEM education in America ...
(Date:10/10/2017)... ... October 10, 2017 , ... USDM Life Sciences , ... life sciences and healthcare industries, announces a presentation by Subbu Viswanathan and Jennifer ... “Automating GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach to ...
(Date:10/9/2017)... ... ... At its national board meeting in North Carolina, ARCS® Foundation President ... and Astronomy, has been selected for membership in ARCS Alumni Hall of Fame ... Prize in Fundamental physics for the discovery of the accelerating expansion of the universe, ...
(Date:10/7/2017)... (PRWEB) , ... October 06, ... ... leader in Hi-C-based genomic technologies, launched its ProxiMeta™ Hi-C metagenome deconvolution product, ... Hi-C kit and accompanying cloud-based bioinformatics software to perform Hi-C metagenome deconvolution ...
Breaking Biology Technology: