Navigation Links
Study shows compulsive eating shares addictive biochemical mechanism with cocaine, heroin abuse
Date:3/28/2010

e same underlying neurobiological mechanisms. In the study, the animals completely lost control over their eating behavior, the primary hallmark of addiction. They continued to overeat even when they anticipated receiving electric shocks, highlighting just how motivated they were to consume the palatable food."

The scientists fed the rats a diet modeled after the type that contributes to human obesityeasy-to-obtain high-calorie, high-fat foods like sausage, bacon, and cheesecake. Soon after the experiments began, the animals began to bulk up dramatically.

"They always went for the worst types of food," Kenny said, "and as a result, they took in twice the calories as the control rats. When we removed the junk food and tried to put them on a nutritious diet what we called the 'salad bar option' they simply refused to eat. The change in their diet preference was so great that they basically starved themselves for two weeks after they were cut off from junk food. It was the animals that showed the "crash" in brain reward circuitries that had the most profound shift in food preference to the palatable, unhealthy diet. These same rats were also those that kept on eating even when they anticipated being shocked."

Lethally Simple

What happens in addiction is lethally simple, Kenny explained. The reward pathways in the brain have been so overstimulated that the system basically turns on itself, adapting to the new reality of addiction, whether its cocaine or cupcakes.

"The body adapts remarkably well to changeand that's the problem," said Kenny. "When the animal overstimulates its brain pleasure centers with highly palatable food, the systems adapt by decreasing their activity. However, now the animal requires constant stimulation from palatable food to avoid entering a persistent state of negative reward".

After showing that obese rats had clear addiction-like food seeking behaviors, Johnson and Kenny next in
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

0

GOOD

Page: 1 2 3 4

Related biology news :

1. Single gene dramatically boosts yield, sweetness in tomato hybrids, CSHL-Israeli study finds
2. Rochester study connects workplace turmoil, stress and obesity
3. Rodeo bull goes head-to-head with zoo dolphins in a study of balance
4. New study may explain how weight-loss surgery reverses type 2 diabetes
5. To close achievement gap, US must address major health risks for urban minority youth, study finds
6. Tectonics: Precision is hallmark of 20-year study
7. Study explores link between sunlight, multiple sclerosis
8. Study finds genes that keep watch on blood clotting time
9. WPI receives $1.2 million NIST award for pioneering study of wireless body area networks
10. Study details machinery of immune protection against inflammatory diseases like colitis
11. A marine Mr. Mom: Male pipefish gives birth, but some are deadbeat dads, study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2013)... a commitment to the support of underrepresented minority ... Foundation has announced the inaugural AGA Investing in ... by the National Institute of Diabetes and Digestive ... underrepresented minority students to further their research careers ... establishing this new award, AGA demonstrates its commitment ...
(Date:5/16/2013)... used ancient shorelines to predict the stability of today,s largest ... shoreline from three million years ago, for example when ... to be evidence of a high sea level due to ... many scientists to think that if the world,s largest ice ... the same in our modern, progressively warming world. , ...
(Date:5/16/2013)... May 16, 2013 The relationship between the ... has not been clear. Schizophrenia is commonly associated ... There are clues that reduced IQ may be ... example, reduced cognitive ability may precede the onset ... present in healthy relatives of people diagnosed with ...
Breaking Biology News(10 mins):Underrepresented minority students receive fellowships in digestive disease and nutrition research 2World's biggest ice sheets likely more stable than previously believed 2Genetic risk for schizophrenia is connected to reduced IQ 2
... reporting the first use of ordinary cotton thread and ... device microscopic technology that can transport fluids for ... chips shrink room-sized diagnostic testing equipment down to the ... in medicine, environmental sensing, and other areas. Their study ...
... the ethical dilemma involved in using human embryonic stem ... In particular, they are looking for drug-like chemical compounds ... cells now obtained from human embryos. That,s the topic ... (C&EN), ACS, weekly newsmagazine. C&EN Associate Editor Sarah ...
... including international researchers with a scientist from Cardiff University, ... panda,s unusual biological traits, including its famously restricted diet. ... genome for the first time and now, the genetic ... for the endangered species. Giant pandas are ...
Cached Biology News:Giant panda genome reveals new insights into the bear's bamboo diet 2
(Date:5/17/2013)... TRIANGLE PARK, N.C., USA (PRWEB) May 17, 2013 ...     Green Globes Certified for sustainability , ... and insect pressures , Syngenta ... opening celebration today at the company’s RTP Innovation Center. ... Lab allows company researchers to simulate any agricultural climate ...
(Date:5/17/2013)... 17, 2013 /PRNewswire-iReach/ -- Aridis is pleased to ... Switzerland -based Kenta Biotech to ... antibody (mAb) products, and technologies. This asset portfolio ... treatment of infections by common pathogens including drug ... Pseudomonas aeruginosa , Acinetobacter baumannii ...
(Date:5/17/2013)... May 17, 2013 RURO Inc. ... version 4.1, a versatile refinement to the smart ... solution, improves its advanced methodical management for transgenic ... ezColony 4.1. The network-based platform provides user access ... research. While continuing to emphasize streamlined tasks, such ...
(Date:5/16/2013)... The Stirling Ultracold Model SU780U ultra-low ... USA, won the Outstanding New Product Award presented on ... and Environmental Repositories (ISBER) at their annual meeting in ... recognizes the company’s development and introduction of the world’s ... was presented to Global Cooling’s CEO Neill Lane by ...
Breaking Biology Technology:Syngenta Opens Unique $72 Million Advanced Crop Lab 2Syngenta Opens Unique $72 Million Advanced Crop Lab 3Aridis Pharmaceuticals Announces Acquisition of Monoclonal Antibody Products and Technologies From Kenta Biotech 2Aridis Pharmaceuticals Announces Acquisition of Monoclonal Antibody Products and Technologies From Kenta Biotech 3RURO Introduces ezColony 4.1 – The Versatile Transgenic Animal Colony Management Software 2Stirling Ultracold Ultra-Low Freezer Wins 2013 Outstanding New Product Award at International Biorepository Conference, Sydney, Australia 2
... the accelerated development of new, safe and effective ... US and around the world, will become greater ... State University and Quintiles ( www.quintiles.com ), a ... leader in managing clinical research. The ...
... potential to save tens of thousands of lives each ... at the University of Massachusetts and the Serum Institute ... results from a Phase 1 study. The recently completed ... in protective antibody levels in the serum of treated ...
... ultrafine coal slurry has been successfully tested at the ... technology offers the possibility of reducing the coal slurry ... this new technology was presented Sept. 15 at the ... Cleaning coal after it has been mined is done ...
Cached Biology Technology:Drug Development in Arizona Gets Boost Following ASU-Quintiles Agreement 2New treatment for rabies advances after successful phase 1 trial in India 2New treatment for rabies advances after successful phase 1 trial in India 3Commercial-scale test of new technology to recover coal from sludge successful 2Commercial-scale test of new technology to recover coal from sludge successful 3
Mouse monoclonal [050-04] to C2 ( Abpromise for all tested applications). entrezGeneID: 717 SwissProtID: P06681...
C/EBPalpha Antibody Shipping Temperature: Cold Storage Temperature: -20C...
...
AADAC Immunogen: AADAC (NP_001077, 201 a.a. ~ 301 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Biology Products: