Navigation Links
Study shows a key protein helps control blood pressure
Date:12/23/2009

University of Iowa researchers have shown that a protein channel helps nerve sensors in blood vessels keep blood pressure in check. Without the protein channel, known as ASIC2, the sensors are unable to send the brain the signals it needs to properly control blood pressure.

The finding, which was based in animal models, is important because it could be used to create new treatments to prevent high blood pressure (hypertension). The study results appear in the Dec. 24 print issue of the journal Neuron.

"Sensors in your body's blood vessels sense when your blood pressure goes up, for instance, when you get mad at someone," said the study's principal investigator Frank Abboud, M.D., professor of internal medicine and molecular physiology and biophysics at the University of Iowa Carver College of Medicine and director of the Cardiovascular Research Center at the University of Iowa. "These built-in sensors perceive the change and trigger a nearly instantaneous adjustment by sending signals to the brain, which in turn tells the blood vessels how to adjust.

"By knowing more about what makes these sensors -- known as baroreceptors -- malfunction, we may be able to find ways to make them work properly and prevent high blood pressure," added Abboud, who also holds the Edith King Pearson Chair in Cardiovascular Research and is emeritus head of the University of Iowa Department of Internal Medicine.

In the current study, the team showed that the ASIC2 channel was present in the nerve cells of mice blood vessels and that when the channel was defective, the nerve activity was also defective. They also created a mouse model that did not have the gene that codes for the protein channel and thus had no ASIC2 channels. These mice without ASIC2 channels had high blood pressure. The channels play a key role in the electrical activity that is needed to control blood pressure.

"The ASIC2 channel allows a current to be generate
'/>"/>

Contact: Becky Soglin
becky-soglin@uiowa.edu
319-356-7127
University of Iowa
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New study finds catch shares improve consistency, not health, of fisheries
2. Michigan State University study sheds light on microscopic flower petal ridges
3. Bioengineered materials promote the growth of functional vasculature, new study shows
4. UR study reveals chemos toxicity to brain, possible treatment
5. Study shows loss of 15-42 percent of mammals in North America
6. UA-led study grapples with health effects of low-intensity warfare
7. Killer catfish? Venomous species surprisingly common, study finds
8. Berkeley Lab researchers participate in Homeland Security study of subway airflow
9. Study reveals H1N1 unexpected weakness
10. Tropical birds waited for land crossing between North and South America: UBC study
11. Studying hair of ancient Peruvians answers questions about stress
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... ATLANTA , April 27, 2015  For more ... and trade show has been the premier worldwide event ... Systems 2015 is a must-attend event for any local, ... insight into the emerging commercial markets and current applications ... and innovations of this projected $48 billion industry, and ...
(Date:4/20/2015)... The announcement comes as demand for fire vault ... Ireland,s foremost records management company, has secured ... impressive track record of clients within the first 12 months, ... sector in Dubai . As a result, ... a further eight staff members at its Irish headquarters. The ...
(Date:4/13/2015)... , April 13, 2015  higi, a leading ... ways to more fully engage with their communities around ... industry-leading, privacy protected and secure API.  ... enables the most accessible, affordable, and convenient vehicle to ... The API will allow ...
Breaking Biology News(10 mins):UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3
... by St. Jude Children,s Research Hospital scientists has identified ... targeting an innate immune system component in a bid ... researchers demonstrated that the primary function of one of ... in turn dampens the immune response to infections and ...
... -- Researchers at Georgetown Lombardi Comprehensive Cancer Center have ... determinant of resistance to anti-estrogen therapy used to treat ... the July 1 issue of Cancer Research , ... breast cells undergo stress induced by the agents tamoxifen ...
... month,s Physics World, Steve Haake, director of the Centre for ... that the men,s 100 m sprint will be one event ... called the "performance-improvement index", which uses very simple physics to ... over the last 100 years. The model shows that ...
Cached Biology News:Innate immune system protein provides a new target in war against bacterial infections 2Innate immune system protein provides a new target in war against bacterial infections 3Single protein promotes resistance to widely used anti-estrogen drugs 2Single protein promotes resistance to widely used anti-estrogen drugs 3Physics confirms sprinters are performing better than ever before 2
(Date:5/28/2015)... May 28, 2015 The Academy of Model ... Aviation Day on August 15, 2015. National Model Aviation Day ... and to introduce model flying to the general public. , ... clubs to participate in the celebration by hosting events in ... host National Model Aviation Day events. View our online ...
(Date:5/28/2015)... CARLOS, Calif. , May 28, 2015 /PRNewswire/ ... testing, today announced a study published in ... the Panorama single-nucleotide polymorphism (SNP)-based non-invasive prenatal test ... the first trimester. A study ... that complete molar pregnancies occur in about 1 ...
(Date:5/28/2015)... May 28, 2015 BioNorth Texas ... and representing the life sciences industry in northern ... Directors meeting at The Foundry in Dallas on ... organization brought together a broad spectrum of biotech ... the organization's early successes in partnering with key ...
(Date:5/28/2015)... Mass. , May 28, 2015 RXi ... focused on discovering and developing innovative therapeutics, primarily in ... pricing of a public offering of 26 million units ... share for gross proceeds of approximately $10.4 million. Each ... (ii) a 13-month overallotment purchase right to purchase 0.50 ...
Breaking Biology Technology:Model flying pilots celebrate the Academy of Model Aeronautics Foundation’s Third Annual National Model Aviation Day 2First Confirmed Detection of a Complete Molar Pregnancy with Cell-Free DNA Test 2First Confirmed Detection of a Complete Molar Pregnancy with Cell-Free DNA Test 3BioNorthTX Holds Inaugural Board of Directors Meeting 2BioNorthTX Holds Inaugural Board of Directors Meeting 3RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 3
... 2011 PharmAthene, Inc. (NYSE Amex: PIP ... and chemical threats, today announced the appointment of Brian ... September 22, 2011. Mr. Markison was recently ... Officer for Nycomed U.S. which will be spun out from the ...
... Inc., a biopharmaceutical company focused on the development of ... today that it presented positive results from a Phase ... severe chronic obstructive pulmonary disease (COPD), a large and ... the annual meeting of the European Respiratory Society (ERS). ...
... - Clean solutions to human energy demands are essential to ... energy at our disposal, we have yet to learn how ... to University of Toronto chemistry professor Greg Scholes, the answers ... nature. "Solar fuel production often starts with the energy ...
Cached Biology Technology:PharmAthene Appoints Brian A. Markison to the Company's Board of Directors 2PharmAthene Appoints Brian A. Markison to the Company's Board of Directors 3Elevation Pharmaceuticals Presents Positive Phase 2a Results in COPD Patients at the European Respiratory Society Annual Congress 2Elevation Pharmaceuticals Presents Positive Phase 2a Results in COPD Patients at the European Respiratory Society Annual Congress 3Elevation Pharmaceuticals Presents Positive Phase 2a Results in COPD Patients at the European Respiratory Society Annual Congress 4Elevation Pharmaceuticals Presents Positive Phase 2a Results in COPD Patients at the European Respiratory Society Annual Congress 5Nature offers key lessons on harvesting solar power, says U of T chemistry professor 2
... siRNA while maintaining high cell viability ... simultaneously , Fast: less than ... incubation , Highly reproducible results ... use with the Bio-Rad Gene Pulser Xcell ...
100 adhesive strips....
Request Info...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Biology Products: