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Study shines new light on genetic alterations of aggressive breast cancer subtype
Date:8/7/2014

CCDC170 genes," said Wang.

In 200 tumor samples studied, 8 were found positive for the ESR1-CCDC170 gene fusion. The tumor samples were made available through the Lester and Sue Smith Breast Center's Tumor Bank. In further studies in the lab, the team observed that when ESR1-CCDC170 was introduced into ER-positive breast cancer cells, there was increased cell motility and invasion, as well as enhanced tumor formation, which could explain the increased aggressiveness of ESR1-CCDC170 human tumors.

"The rearrangements between the genes were very cryptic, which makes it very difficult to be detected by conventional cytogenetic approaches," said Wang. "This finding is important because it sheds new light on a much needed better understanding about what may cause these tumors to be more aggressive." The findings also signal a new concept of estrogen receptor pathobiology in breast cancer.

This project is co-advised by Dr. Rachel Schiff, associate professor in the Smith Breast Center at Baylor, and the co-lead authors include Drs. Jamunarani Veeraraghavan, Ying Tan, and Xi-Xi Cao, all of Baylor.

"The aggressive luminal B subtype of breast cancer is a heterogeneous and complex disease. In the era of precision medicine, the current study emphasizes the importance and promise of integrative genomic research methodologies. This approach can identify genetic aberrations that may drive the development and progression of these aggressive tumors and that may guide more personalized effective therapeutic strategies," said Schiff.


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Contact: Glenna Picton
picton@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

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