Navigation Links
Study sheds light on late phase of asthma attacks
Date:8/12/2011

te response is brought about," said Professor Maria Belvisi, from the National Heart and Lung Institute at Imperial College London, who led the research. "Our study in animals suggests that anticholinergic drugs might help to alleviate these symptoms, and this is supported by the recent clinical data. We are seeking funding to see if these findings are reproduced in proof of concept clinical studies in asthmatics."

The researchers hypothesised that sensory nerves were involved after observing that anaesthesia prevented the late asthmatic response in mice and rats. They succeeded in blocking the late asthmatic response using drugs that block different aspects of sensory nerve cell function, adding further evidence for this idea.

After establishing that sensory nerves detect the allergen, the researchers tested the effect of tiotropium, an anticholinergic drug that is used to treat chronic obstructive pulmonary disease. Tiotropium blocks the receptor for acetylcholine, which is released by nerves in the parasympathetic nervous system. Tiotropium also blocked the late asthmatic response, suggesting that parasympathetic nerves cause the airways to constrict.

The study was funded by the Medical Research Council (MRC). Professor Stephen Holgate, MRC funding board chair and an expert on asthma, said: "Unravelling the complex biology of asthma is vitally important, as it is an extremely dangerous condition which exerts lifelong damaging effects. The Medical Research Council is committed to research that opens doors to improving disease resilience, particularly in conditions which attack our body over the long-term. Studies like this are making really important progress and whilst we must always be cautious when taking findings from rodents into humans, these are very interesting and potentially important results."


'/>"/>

Contact: Sam Wong
sam.wong@imperial.ac.uk
44-207-594-2198
Imperial College London
Source:Eurekalert

Page: 1 2

Related biology news :

1. BUSM professor awarded $13.3 million to study potential treatments to prevent STDs
2. Decade-long study reveals recurring patterns of viruses in the open ocean
3. Study builds on plausible scenario for origin of life on Earth
4. Penn study shows an ancient crop effective in protecting against a 21st century hazard
5. Finding their way: Study shows connection between academic direction and student learning
6. Study: Severe low temperatures devastate coral reefs in Florida Keys
7. UGA researchers study threats to white sturgeon
8. UCLA study shows man-made fat may limit damage to heart attack victims
9. Montana State University team surprised by results of lung, mold study
10. UCLA life scientists study of abalone yields new insights into sexual reproduction
11. USDA scientists study effects of rising carbon dioxide on rangelands
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... biology and other science courses are increasingly being ... now they have a new textbook to help ... published this month by Princeton Press and co-authored ... and Biological Synthesis (NIMBioS), teaches readers about basic ... to explore and explain biological phenomena. , Suitable ...
(Date:8/19/2014)... awarded a nearly $40,000 grant from the National Center ... the National Park Service (NPS) and U.S. Department of ... of the energy efficiency and cost effectiveness of radiant ... , Radiant barriers are reflective thermal insulations commonly fitted ... reducing the amount of heat emitted in the direction ...
(Date:8/19/2014)... are superior to humans and animals in a number ... which enables them to regrow entire organs. After being ... back its entire crown. But there is one major ... literally rooted to the habitats in which they live ... In response to this dilemma, plants have developed mechanisms ...
Breaking Biology News(10 mins):New textbook introduces undergraduates to mathematics for the life sciences 2UTSA researcher awarded $38K+ to evaluate energy efficiency options for historic homes 2UTSA researcher awarded $38K+ to evaluate energy efficiency options for historic homes 3How steroid hormones enable plants to grow 2
... has been heading north since it was first introduced from ... invader chokes out native species and has dramatically altered wetland ... have a vulnerability after all: the northern climate. Canadian ... carries a severe reproductive penalty that may limit its spread. ...
... Mich. A team of Michigan State University scientists ... have uncovered the inner workings of a key iron-containing ... medicines or understand how enzymes repair DNA. ... that is important in metabolism. Enzymes in this family ...
... ... ... , ... , , , ...
Cached Biology News:Climate may keep beautiful killer plant in check 2MSU scientists unlock key enzyme using newly created 'cool' method 2ModiFace Launches iLab: An iPhone and iPad App Experimentation Laboratory 2ModiFace Launches iLab: An iPhone and iPad App Experimentation Laboratory 3
(Date:8/19/2014)... One of the major limitations ... inadequate vascular supply. Nutrient and gas transport throughout ... critical for successful regeneration and integration into the ... in vascularization and promote angiogenesis in a variety ... design and architecture, and enhancing scaffolds with stem ...
(Date:8/19/2014)... Calif. (PRWEB) August 19, 2014 ... campaign to raise $200,000 to fund a corporate ... device. , This development is a critical ... model of care to the implementation of personalized ... method of practicing medicine. , Indiegogo contributions will ...
(Date:8/19/2014)... 19, 2014 Research and ... the "Spectroscopy Equipment and Accessories - ... their offering. This report ... and Accessories in US$ Thousands by the ... Raman Spectrometers, NMR-EPR Spectrometers, Near Infrared (NIR) ...
(Date:8/19/2014)... , Aug. 19, 2014 /PRNewswire/ - iCo Therapeutics ... ICOTF), today reported results of its Oral Amphotericin ... HIV reservoirs.  The study, conducted by ImmuneCarta®, the ... in vitro effectiveness of Oral Amp B ... present in individuals despite intensive treatment with antiretroviral ...
Breaking Biology Technology:Vascularization in Tissue Engineering Highlighted at 12th New Jersey Symposium on Biomaterials Science 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 3Global Spectroscopy Equipment and Accessories - Strategic Business Report 2014 2iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 2iCo Therapeutics Announces Positive Oral Amphotericin B Study Results 3
... University in Sendai, Japan, has purchased a LEAP 3000 metrology ... of Madison, Wis. The Tohoku University system is ... six months. Imago delivered the system in conjunction with its representatives ... removing and examining individual atoms, enabling metrology at the atomic scale. ...
... National Science Foundation -funded network, University of Wisconsin-Madison engineering ... nation's top science museums to create hands-on exhibits about technology ... it. , ,The Museum of Science , Boston, the ... , San Francisco, are leading the $20 million Nanoscale Informal ...
... adoption curves, just take a look at the data from ... that business blogging isnt just about to take off ... 55% of corporations have adopted blogs for both internal ... organizations launched their blogs within the last year, and most ...
Cached Biology Technology:Engineers help turn science into interactive exhibits 2Staggering stats on blog adoption 2Staggering stats on blog adoption 3
Rabbit polyclonal to SpUlp2 ( Abpromise for all tested applications). Antigen: Synthetic peptide: SNNERQSLSSGSND, corresponding to amino acids 622-635 of Schizosaccharomyces pombe SpUlp2...
Rabbit polyclonal to Factor IX ( Abpromise for all tested applications). entrezGeneID: 2158 SwissProtID: P00740...
Mouse monoclonal [CLB-SW16 (formerly 708)] to CD42d (rating: ****) ( Abpromise for all tested applications). entrezGeneID: 2814 SwissProtID: P40197...
ANTI-HUMAN CYTOKINES, GROWTH FACTORS (polyclonal rabbit (or goat) antibodies) Human TARC - Biotin...
Biology Products: