Navigation Links
Study sheds light on how cells transport materials along crowded intercellular 'highways'
Date:12/13/2012

plified transportation system.

They found that the dots moved more slowly as the traffic increased, but that they were able to travel farther before becoming detached from the microtubule. They also observed the pausing of the quantum dots, with the number of pauses increasing, but the length of the pauses decreasing, as the concentration of motor proteins is increased. The authors hypothesize that as the concentration of motor proteins increased, several of them became bound to each quantum dot. Much like trucks driving side-by-side down a multilane highway, the motor proteins likely became attached to different protofilaments along the microtubule (microtubules are made of 13 parallel protofilaments arranged into a hollow tube).

As an individual protein encountered an obstacle (another motor protein, for example), the motion of the dot would pause until the force exerted by the other proteins attached to the dot caused it to become detached from the blocked protein. The greater the number of proteins pulling the dot along the microtubule, the greater the force acting on it and the more quickly it would become detached from blocked proteins (and thus, the briefer the pauses in its forward motion).

In this way, motor proteins were able to cooperate to move cargo around roadblocks and to keep cargo attached to the microtubules despite heavy traffic, Tzel says. "This is the first study to really look at the operation of the intracellular transportation system crowded conditions that are typical of living cells," he noted.

"It is important to understand how this system works and what can keep it from functioning properly because it is vital to the survival of all animal cells and motor proteins that make many fundamental biological processes, such as cell division, possible," he adds. "When the transport mechanism fails to work properly, it can lead to a variety of illnesses, including neurodegenerative diseases like Huntington's and
'/>"/>

Contact: Michael Dorsey
mwdorsey@wpi.edu
508-831-5609
Worcester Polytechnic Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study sheds light on how cells transport materials along crowded intercellular 'highways'
(Date:7/30/2014)... Monash University Professor Steven Chown has been awarded ... Medal for Excellence in Antarctic Research. , SCAR, ... coordinates high quality international scientific research in the ... Antarctic region in the Earth system. The organisation ... Antarctic Treaty System, responsible for governing the region. ...
(Date:7/30/2014)... for spinal cord injury (SCI), traumatic brain injury (TBI) ... deal has been learned over the past 30 years ... that regulate axon growth, but this large body of ... Prof. Lemmon and his team from University of Miami ... causes, but a consensus is emerging that one contributing ...
(Date:7/30/2014)... , July 30, 2014 The Nano-Bio ... United States Air Force Research Laboratory (AFRL), has ... Binghamton University to develop electronics ... (HPM). The $425,000 project, with contributions from the ... i3 Electronics, Inc. ( Endicott, N.Y. ...
Breaking Biology News(10 mins):Nano-Bio Manufacturing Consortium Awards Funding to Binghamton University for Development of Electronics and Biometric Sensor Platforms 2Nano-Bio Manufacturing Consortium Awards Funding to Binghamton University for Development of Electronics and Biometric Sensor Platforms 3
... $50 million to a multi-institution collaborative headquartered at the ... cyberinfrastructure for the biological sciences. The renewal ... the Texas Advanced Computing Center (TACC) at the University ... New York, and University of North Carolina Wilmington (UNCW), ...
... Researchers have discovered why multiple myeloma, a difficult to cure ... effective treatment that can keep the disease at bay for ... colleagues at Princess Margaret Hospital in Toronto, researchers from Mayo ... in Phoenix were part of the team that conducted the ...
... NEW YORK , Sept. 18, 2013 ... research report is available in its catalogue: ... Global Biometrics Market ... the Market Grow Manifold,This study analyzes the ...
Cached Biology News:$50 million NSF grant to advance cyberinfrastructure for big data in life sciences 2$50 million NSF grant to advance cyberinfrastructure for big data in life sciences 3$50 million NSF grant to advance cyberinfrastructure for big data in life sciences 4Research team uncovers root cause of multiple myeloma relapse 2Emerging Opportunities in Global Biometrics Market 2Emerging Opportunities in Global Biometrics Market 3Emerging Opportunities in Global Biometrics Market 4Emerging Opportunities in Global Biometrics Market 5
(Date:7/30/2014)... 30, 2014 Sales Horizons, a leader ... blended sales training programs for companies engaged in complex ... used by thousands of salespeople over 25 years in ... program can be customized to address the unique sales ... blended sales training program consists of two parts: ...
(Date:7/30/2014)... July 30, 2014 With the ... of personal health expenditure as well as the ... system, China diagnostic reagent industry has been developing ... 90%. In 2013, Chinese in vitro diagnostics market ... came from in vitro diagnostic reagents. , ...
(Date:7/30/2014)... BCC Research ( http://www.bccresearch.com ) reveals ... in Industrial Applications , the global market for industrial ... by 2018, registering a five-year compound annual growth rate ... recorded in the detergent enzyme segment with a CAGR ... has influenced almost every sector of industrial activity, ranging ...
(Date:7/30/2014)... July 30, 2014 Yuma Regional ... and complementary therapies brings comprehensive cancer care to ... Yuma Regional Cancer Center has officially opened. A ... program includes services such as open, semi-private and ... American Cancer Society Resource Center, hematology, rehabilitation center, ...
Breaking Biology Technology:Sales Horizons Launches New Blended Sales Training Programs to Companies Engaged in Complex B2B Sales 2Sales Horizons Launches New Blended Sales Training Programs to Companies Engaged in Complex B2B Sales 3China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 2China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 3Global Market for Industrial Enzymes to Reach Nearly $7.1 Billion by 2018; Detergent Enzyme Market to Record Maximum Growth 2Global Market for Industrial Enzymes to Reach Nearly $7.1 Billion by 2018; Detergent Enzyme Market to Record Maximum Growth 3Sate-of-the-Art Yuma Regional Cancer Center Officially Opens 2
... FRANCISCO , Jan. 13 Today, endpoint ( ... users to design and deploy clinical trial IRT systems in ... Leveraging a background of more than 12 years designing Integrated ... designed PULSE to balance speed of deployment with flawless quality. ...
... ROCHESTER, N.Y. , Jan. 12 After a decade of ... decelerated and may have even fallen when adjusted for inflation.  That is ... the American Medical Association .   , "The era of rapid expansion ... Ray Dorsey , M.D. , a neurologist at the ...
... , ... Institute announces twenty-four exhibitors to showcase new products at the 17th Molecular Medicine Tri-Conference, ... Molecular Medicine Tri-Conference is the predominant event on the west coast focused on integrating ... ...
Cached Biology Technology:endpoint Introduces First Fully Configurable IRT System 2Study: Era of Rapid Growth in Biomedical Research Over 2Study: Era of Rapid Growth in Biomedical Research Over 3Study: Era of Rapid Growth in Biomedical Research Over 4Study: Era of Rapid Growth in Biomedical Research Over 5Study: Era of Rapid Growth in Biomedical Research Over 6A Host of New Products to be Showcased at 2010 Molecular Medicine Tri-Conference 2A Host of New Products to be Showcased at 2010 Molecular Medicine Tri-Conference 3A Host of New Products to be Showcased at 2010 Molecular Medicine Tri-Conference 4
Request Info...
Ready for formulation or direct injection into animals Provided in convenient 100, 250, 1000 and 10,000 nmol sizes HPLC purified, salt free, sterile filtered, and endotoxin tested ...
... siRNA service provides the premium quality siRNAs ... Custom siRNAs can be readily ordered online ... sequence, or by providing the sense and ... Silencer Validated and Silencer Pre-designed siRNAs, which ...
Human FGF R2 (alpha isoforms) MAb (Clone 98706)...
Biology Products: