Navigation Links
Study sheds light on genetic differences that cause a childhood eye disease
Date:10/31/2008

Medical researchers at the University of Alberta have unlocked part of the mystery underlying a childhood eye disease. New research shows how children with some types of glaucoma end up with missing or extra pieces of DNA.

The missing or extra bits of DNA are called copy number variations (CNVs). The U of A research team had previously shown how they play a major role in causing some types of pediatric glaucoma a disease that can lead to blindness. In their current study, published in Human Molecular Genetics, the authors describe how the CNVs that cause childhood glaucomas are formed.

Using genetic samples from patients living with pediatric glaucoma, the research team studied the locations where extra or missing pieces of DNA begin and end. Close examination of these break points allowed the team to determine how these copy number variations occur.

"Our findings broaden the mechanisms known to cause copy number variations, which improves our understanding not only of pediatric glaucoma, but also of the growing number of genetic diseases linked to copy number variations, including heart disease and psoriasis. We're really only looking at the tip of the iceberg in terms of how CNVs cause disease." said Dr. Ordan Lehmann, an associate professor with the Faculty of Medicine & Dentistry at the University of Alberta and an ophthalmologist with Alberta Health Services. "These findings will also help us to improve the detection of pediatric glaucoma and, by allowing earlier diagnosis, will help lead to earlier treatment of this condition."


'/>"/>

Contact: Lindsay Elleker
lindsay.elleker@ualberta.ca
780-492-0647
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2015)... DALLAS , June 25, 2015 ... report "Fingerprint Sensors Market by Type (Swipe & Area), Technology, ... (Mobile, Government, Healthcare, Commercial Security & Others) & ... published by marketsandmarkets, the said market is expected ... CAGR of 17.1%. Browse 76 ...
(Date:6/24/2015)... JOSE, Calif. , June 24, 2015 /PRNewswire/ ... developer of human interface solutions, today announced that ... sensor to provide secure authentication for its latest ... recently reached more than 200 million shipments of ... with Sharp reinforces Synaptics, strength, scalability and leadership ...
(Date:6/23/2015)...   Valencell, a leader in performance ... recent study that illustrates its PerformTek biometric technology ... In a study conducted at Valencell,s Biometric Lab, ... Apple Watch against a chest strap – the ... The study demonstrated that Valencell,s biometric technology delivers ...
Breaking Biology News(10 mins):Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4Synaptics Brings Natural ID Technology to Sharp's Newest Flagship Smartphone 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 3
... found in the virulent avian influenza virus strain called H5N1 ... double-stranded RNA formed during viral infection, which otherwise would prompt ... of Medicine researchers in an online report in the journal ... protein NS1 combine to form tiny tubules where double-stranded RNA ...
... Iver Anderson is developing a cheaper and better way to ... manufacture artificial joints. That could mean titanium joints, ... could be affordable enough to replace stainless steel joints, which ... And that could save patients the additional surgeries required to ...
... in German . , Bayreuth/Leipzig. Extreme weather ... A one-month drought postpones the time of flowering of grassland ... 4 days. With this a so-called 100-year drought event equates ... of an important early flowerer, the common Birds-foot Trefoil ( ...
Cached Biology News:Protein 'tubules' free avian flu virus from immune recognition 2State fund advances titanium powder research, 9 other Iowa State projects 2State fund advances titanium powder research, 9 other Iowa State projects 3State fund advances titanium powder research, 9 other Iowa State projects 4Extreme weather postpones the flowering time of plants 2
(Date:7/1/2015)... Isagenix International, a leading global health and ... Silver, and three Bronze Stevie® Awards at the 2015 ... Chicago this month.The American Business Awards ... in the U.S. "Winning is a ... leaders, cultivating talent, creating a unified team, and crafting ...
(Date:7/1/2015)... , July 1, 2015  UCB, a ... ), a global leader in designing, transforming, and ... Innovation Award in recognition of their close collaboration ... in UCB,s global business services (GBS) finance organization. ... providers and clients that work together effectively to ...
(Date:6/30/2015)... 2015  NASA astronaut Kjell Lindgren , who is ... first mission to the International Space Station , will ... a.m. EDT Tuesday, July 7. Lindgren will participate ... Russia . The interviews will be preceded at ... mission training. To schedule an interview, media must ...
(Date:6/30/2015)... Church, VA (PRWEB) , ... June 30, 2015 ... ... and strategy services to the federal government, announced in a paper published this ... scientists uncovered a potential problem with the diagnostic techniques currently used to detect ...
Breaking Biology Technology:Isagenix Earns Nine American Business Awards 2Isagenix Earns Nine American Business Awards 3UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 2UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 3UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 4UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 5NASA Astronaut Preps for First Space Station Mission, Available for Media Interviews 2Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 2Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 3Noblis and Government Scientists Identify New Genomic Signatures of Ebola Using Whole Genomic Sequencing and Innovative BioVelocity Analytics Tool 4
... No more siRNA design and testing , Entire procedure , ... , Includes reagents for ... Simplify Your Gene , Silencing Experiments ... (siRNAs) to induce targeted gene , silencing in mammalian ...
... Patel, and David Quilter , (GeneXP Biosciences Inc.) ... Efficient and cost-effective method for synthesizing , ... Increase throughput by >10-fold ... and consistent results , , ...
... Get Full-length cDNA , ... to improve production of full-length cDNA. This engineered reverse transcriptase, , ... href="http://www.ambion.com/catalog/CatNum.php?2048">ArrayScript , ... cDNA than wild type RTs, and rivals even ...
Cached Biology Technology:Avoid siRNA Design Altogether! 2Avoid siRNA Design Altogether! 3Automated RNA Amplification for Arrays 2Automated RNA Amplification for Arrays 3Automated RNA Amplification for Arrays 4Automated RNA Amplification for Arrays 5ArrayScript RT: Maximize Yields of Full-length cDNA 2ArrayScript RT: Maximize Yields of Full-length cDNA 3
Identify and characterize Phosphoinositide (PI(4,5)P2) binding...
... These skirted micro test tubes are used ... polypropylene, these tubes have uniform walls for ... with separate O-ring screw caps. The O-rings ... have an operating range from -55 to ...
... Antibody Coated CELlulose) was developed in the ... Kent, one of the earliest commercial pioneers ... the product range in 1987. Sac-Cel rapidly ... developing their own "in house" radioimmunoassays, and ...
Determine relative degree of protein binding to phosphoinositides...
Biology Products: