Navigation Links
Study sheds light on genetic 'clock' in embryonic cells
Date:11/13/2012

inter-cellular signaling pathway blocked, however, the oscillations were no longer synchronized among neighboring cells. The cellular clocks were still ticking, in other words, but not in unison. This finding confirms that the Notch pathway serves to coordinate timing among cells a crucial role, since the cells must act in concert in order to form vertebrae.

By observing normal zebrafish embryos, the researchers were also able to show that cells desynchronize their oscillations while performing cellular division, then later resynchronize with their neighbors as they proceed collectively to form vertebrae.

"In humans, defects in Notch signaling are associated with congenital developmental disorders called spondylocostal dysostosis, that are typified by scoliosis and trunk dwarfism caused by malformed ribs and vertebrae," Amacher notes. "Studies such as ours may provide insight into potential therapies for human disease. It is likely that many cells in our bodies - stem cells, cancer cells - have similar molecular oscillators that regulate response to environmental signals. By unraveling such molecular clocks, we can understand how to modify them and thus change the number of oscillating cells that respond to differentiating signals, providing tremendous insight for studies in stem cell and cancer biology and tissue engineering."

"The formation of the vertebral column is very important, because everything follows from that" in the development of vertebrates, Franois adds. A physicist, he developed the computer tools used to analyze video footage of the zebrafish embryos. Francois's research focuses on the modeling of physical properties of gene networks and their evolution a field that has emerged at the nexus of biology and physics in recent years, following sequencing of the human genome and rapid growth in scientists' understanding of the processes inside cells.


'/>"/>

Contact: Chris Chipello
christopher.chipello@mcgill.ca
514-398-4201
McGill University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/16/2015)... 16, 2015 Between 16 ... present groundbreaking innovations in biometric identification at the ... .      (Photo: http://photos.prnewswire.com/prnh/20150316/735333 ... is well at the forefront: the company,s all ... in Germany . BiometricGate is ...
(Date:3/12/2015)... 12, 2015 Beta Systems ... and access management (IAM) solution for a fixed ... Beta System,s new IAM package, customers benefit from ... from multiple IAM implementations across different industries. The ... well as any necessary services and consulting. It ...
(Date:3/11/2015)... , March 11, 2015   The Sync ... platform to scientifically measure and harness music to ... real-time biometrics and objective measurements of physiology, enabling ... at scale in large populations. It is designed ... and clinicians perform rigorous studies and accelerate the ...
Breaking Biology News(10 mins):DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 2Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 3
... cracked the problem of pod shatter in brassica crops such ... are prone to shatter, causing a 10-25% loss of seeds ... producing a hormone in a specific region of the fruit, ... plant Arabidopsis , completely sealing the seeds inside," says ...
... Paul Anastas, Yale,s Teresa and H. John Heinz III ... to lead the U.S. Environmental Protection Agency,s (EPA,s) Office ... of the Center for Green Chemistry & Green Engineering ... chemical engineering and the School of Forestry & Environmental ...
... alleviate diseases associated with menopause, she didn,t realize her ... hundreds of millions of people. The Northern Arizona ... University of Arizona identified a nontoxic chemical technology that ... feast on crops intended for human consumption. ...
Cached Biology News:Shatter-resistant brassicas 2'Father of green chemistry' Paul Anastas to head EPA research 2NAU discovery could help feed millions 2NAU discovery could help feed millions 3
(Date:3/26/2015)... (PRWEB) March 26, 2015 "In America," the ... the United States that is hosted by legendary film actor ... topic of botany in an upcoming segment. , Botany ... in reality it is actually quite a bit more complicated ... of different types of living organisms, from the smallest bacteria ...
(Date:3/26/2015)... 2015 WriteResult, a premier provider of ... Yale University’s School of Public Health and New Haven ... a 4 month-long project. The goal of the study ... families with free access to fresh produce and nutrition ... concerns like high blood pressure, diabetes and weight gain. ...
(Date:3/25/2015)... 26, 2015 Agnition announced today that ... American Farmer, airing for the first time at 7:30 ... American Farmer will explore the extremely important role soil ... with a patented Microbial Catalyst™ technology that enhances soil ... The segment will air again on April 28. , ...
(Date:3/25/2015)... Md. , March 25, 2015 Optimal ... the Vaccine Industry Excellence (ViE) Award "Best Clinical Site ... consecutive year that Optimal has been selected as a ... Vaccine Congress, receiving a "Highly Recommended" distinction in 2014. ... recognition of the efforts, accomplishments, and positive contributions of ...
Breaking Biology Technology:Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 2Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 3Agnition to be Featured In Upcoming Episode of American Farmer on RFD-TV 2Optimal Research Nominated 2015 Vaccine Industry Excellence (ViE) Award 2
... Corporation (NYSE: SHP ) ("ShangPharma" or ... research and development outsourcing company, today announced that ... Commerce as one of the Top Ten Leading ... top ten companies were announced at the Fourth ...
... development of the first self-powered nano-device that can transmit ... ACS,s journal Nano Letters , they say it ... implantable medical sensors, airborne and stationary surveillance cameras and ... independently without batteries on energy collected from the environment. ...
... June 15, 2011 Solid grounding in science is ... of American leaders. From biochemists and pharmacists to physician ... States job market lies in the fields of healthcare ... online survey conducted by Harris Interactive for University ...
Cached Biology Technology:ShangPharma Corporation Named a Top Ten Chinese Outsourcing Enterprise 2Careers in Healthcare and Science? "Not Interested" Say Half of U.S. Teens 2Careers in Healthcare and Science? "Not Interested" Say Half of U.S. Teens 3Careers in Healthcare and Science? "Not Interested" Say Half of U.S. Teens 4
... The top-of-the-line PowerPac 3000 power ... supply available, ideal for isoelectric focusing, ... native gel electrophoresis, western blotting, and ... 400 W of powre, the PowerPac ...
... GT and PowerPac 3000 system, 220-240 V, is ... x 30 cm vertical slab gel format. The ... which is capable of separating nucleic acids with ... chamber (IPC) assembly (IPC and bonded inner glass ...
The optional fixed lens, 105 mm, is for use with the VersaDoc imaging systems for imaging small samples at high resolution....
... DNA Kit is designed for fast and ... plant cells and tissues. The bead beating ... DNA isolation procedures such as CTAB, phenol, ... alcohol precipitation is not necessary - purified ...
Biology Products: