Navigation Links
Study sheds light on genetic 'clock' in embryonic cells
Date:11/13/2012

inter-cellular signaling pathway blocked, however, the oscillations were no longer synchronized among neighboring cells. The cellular clocks were still ticking, in other words, but not in unison. This finding confirms that the Notch pathway serves to coordinate timing among cells a crucial role, since the cells must act in concert in order to form vertebrae.

By observing normal zebrafish embryos, the researchers were also able to show that cells desynchronize their oscillations while performing cellular division, then later resynchronize with their neighbors as they proceed collectively to form vertebrae.

"In humans, defects in Notch signaling are associated with congenital developmental disorders called spondylocostal dysostosis, that are typified by scoliosis and trunk dwarfism caused by malformed ribs and vertebrae," Amacher notes. "Studies such as ours may provide insight into potential therapies for human disease. It is likely that many cells in our bodies - stem cells, cancer cells - have similar molecular oscillators that regulate response to environmental signals. By unraveling such molecular clocks, we can understand how to modify them and thus change the number of oscillating cells that respond to differentiating signals, providing tremendous insight for studies in stem cell and cancer biology and tissue engineering."

"The formation of the vertebral column is very important, because everything follows from that" in the development of vertebrates, Franois adds. A physicist, he developed the computer tools used to analyze video footage of the zebrafish embryos. Francois's research focuses on the modeling of physical properties of gene networks and their evolution a field that has emerged at the nexus of biology and physics in recent years, following sequencing of the human genome and rapid growth in scientists' understanding of the processes inside cells.


'/>"/>

Contact: Chris Chipello
christopher.chipello@mcgill.ca
514-398-4201
McGill University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... his doctoral student have designed a device based on ... fog and dew., The device could provide water in ... globe., Cheng Luo, professor in the Mechanical & Aerospace ... same College of Engineering department, published "Bioinspired Plate-Based Fog ... Chemical Society) Applied Materials & Interfaces ...
(Date:9/17/2014)... has developed, very cleverly, some lessons on how to ... said Joseph Shaw, director of the Optical Technology Center ... structures at the nanoscale, we,ll discover them." , Some ... August during a conference called "The Nature of Light: ... of the University of Arizona College of Optical Sciences. ...
(Date:9/17/2014)... Researchers in Biomedical Informatics at IMIM (Hospital del Mar ... Catalunya (UPC) have recently published a study in ... an important role in the evolution of new proteins, ... to be discovered., Ribosomes produce proteins from the instructions ... the human genome is RNA containing information for the ...
Breaking Biology News(10 mins):Shorebird's beak inspires UT Arlington research on water collection 2Nature's designs inspire research into new light-based technologies 2Nature's designs inspire research into new light-based technologies 3Parts of genome without a known function may play a key role in the birth of new proteins 2
... is available in Spanish . , ... nematodes could improve the delivery, timing and use of ... machine is the result of a cooperative research and ... and Southeastern Insectaries, Inc., of Perry, Ga. The ...
... for Molecular Pathology (AMP) opposed the National Institutes of ... of a cancer-related proteonomics patent application filed by the ... in response to a request for comments in the ... The Development of a Companion Diagnostic Kit for Predicting ...
... the presence of large mammals in the Amazon, according to ... diversity of ecotourism zones with that of protected areas. Furthermore, ... are not officially protected yet are vital in the ecological ... at the end of the 1980,s as a way of ...
Cached Biology News:Special delivery: Nematode-infected insect cadavers 2AMP opposes exclusive licensing of NIH proteomics patent 23 researchers in the Amazon clear up doubts as to the benefits of ecotourism 23 researchers in the Amazon clear up doubts as to the benefits of ecotourism 3
(Date:9/18/2014)... /PRNewswire-iReach/ -- DeepResearchReports.com adds "2014 Deep Research Report ... "2014 Deep Research Report on Global and China ... Photo - http://photos.prnewswire.com/prnh/20140918/147058 ... and China Acetic Acid Industry" is a professional ... and Global Acetic Acid Market. The ...
(Date:9/18/2014)... D.C. (PRWEB) September 18, 2014 On ... Durbin and Sen. Jim Risch for National Lab Day ... projects from across the national laboratory system. Durbin and ... which aims to increase awareness of the reach of ... technologies and discoveries to address some of our nation's ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 Leatherwood ... FM-4910 listed material, to stay competitive in the ... These high-performance materials ultimately impact product quality and ... and owner. , Established in 1980 in Lewisville, ... as many fabricators have left the business. Much ...
(Date:9/18/2014)... Pennsylvanie, 18 septembre 2014 Mapi, ... en 1974, a été depuis 40 ans ... évaluations cliniques traditionnelles par des évaluations recentrées ... sur les impacts économiques des traitements. ... A cours d,une récente conférence ...
Breaking Biology Technology:Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 2Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 3Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 4Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3Leatherwood Plastics Selects Vycom’s Flametec PVC-C Material to Stay Competitive in Semiconductor and Lab Equipment Industries 21974 - 2014 - Mapi fête ses 40 ans 2
... Ability to Elicit Long-Lasting Tumor Protection In Vivo; Lead ... ... Cancer and/or HIV -, SAN DIEGO, CA, Sept. 24 ... vivo results of its lead therapeutic vaccine candidate for the ...
... availability of ... bone fracture screening, TORONTO, ... in health and wellness solutions, announced,they are developing components for ... assessment. In conjunction with top researchers at Toronto,s University ...
... BIRMINGHAM, Ala., Sept. 24 BioCryst,Pharmaceuticals, Inc. (Nasdaq: ... at the,UBS 2007 Global Life Sciences Conference in ... for Tuesday, September 25, 2007 at 2:00 p.m. ... http://www.biocryst.com . The,presentation will be archived for ...
Cached Biology Technology:Nventa announces publication of HspE7 data 2Nventa announces publication of HspE7 data 3Nventa announces publication of HspE7 data 4Nventa announces publication of HspE7 data 5Cooler Solutions and Leading Research Hospital to Design Revolutionary Osteoporosis Diagnosis Device 2BioCryst to Present at UBS 2007 Global Life Sciences Conference 2BioCryst to Present at UBS 2007 Global Life Sciences Conference 3
... stain has bright fluorescence when bound to dsDNA ... for detecting dsDNA in gels using laser scanners ... nucleic gel acid stain has also found ... bandshift assays. One mL stains 100 minigels. A ...
Synonym: modified Grace's Insect medium...
... acid synthetic peptide whose sequence is derived from bovine rhodopsin ... carboxy terminus): C - S(338) - K - T ... - A - P - A(348). This peptide ... polyclonal antibody that reacts with this product and bovine rhodopsin, ...
... The proteomic service includes protein ... analysis using the PDQuest software package ... MALDI-TOF mass spectrometry. In order to ... sample preparation, data analysis and format ...
Biology Products: