Navigation Links
Study reveals turn 'signals' for neuron growth
Date:12/20/2011

Irvine, Calif., and Arlington, Texas -- Researchers at UC Irvine and The University of Texas at Arlington have discovered how spinning microparticles can direct the growth of nerve fiber, a discovery that could allow for directed growth of neuronal networks on a chip and improve methods for treating spinal or brain injuries.

Michael Berns, the founding director of the Beckman Laser Institute and Medical Clinic at UCI, and Samarendra Mohanty, an assistant professor of physics at UT Arlington, are coauthor of the paper, which is now available online and will appear in the January issue of Nature Photonics

The study is based on Mohanty's hypothesis that neurons can respond to physical (e.g. fluid flow) cues in addition to chemical cues. He conducted the seminal work and observed that a laser-driven spinning calcite microparticle could guide the direction of neuron growth. Its rotation caused a shearing effect by creating a microfluidic flow.

Mohanty's work led Berns' UCI team to test the vaterite "micro-motors" in guiding neurons.

Mohanty said: "This is the first report to demonstrate that neurons can be turned in a controlled manner by microfluidic flow. With this method, we can direct them to turn right or turn left and we can quickly insert or remove the rotating beads as needed. But flow can be generated by any means. In the body, for example, it will be more convenient to use a tube carrying fluids."

The researchers in the UCI experiments used a laser tweezers system to trap a birefringent particle (calcite or vaterite) near axonal growth cones, which are the tips of neurons where connections are made with other neurons or cells. The same laser causes rotation of the particle, which creates the flow, Mohanty said.

The paper reports that the new method successfully turned the growing axon in a new direction up to 42 percent of the time in lab experiments. The authors noted that the method could al
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Hellbender salamander study seeks answers for global amphibian decline
2. Study reveals gender bias of prospective parents
3. Wayne State study finds soybean compounds enhances effects of cancer radiotherapy
4. Study of skates and sharks questions assumptions about essential genes
5. Close family ties keep microbial cheaters in check, study finds
6. Barracuda babies: Novel study sheds light on early life of prolific predator
7. New study shows promise for preventing preterm births
8. 3-year study identifies key interventions to reduce maternal, newborn and child deaths
9. London researchers lead innovative new cancer treatment study
10. Study finds increasing atmospheric concentrations of new flame retardants
11. Fate Therapeutics Announces Promising Data From Phase 1b Study of ProHema at the 2011 American Society of Hematology Annual Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... season upon us, many backyard cooks are turning to ... dogs. But low fat can sometimes mean low satisfaction. ... texture problem in low-fat wieners that are made with ... published in ACS, Journal of Agricultural and Food ... that hot-dog consumers have come to expect just the ...
(Date:7/9/2014)... first-ever global census of Adlie penguins shows that ... 53 percent larger than previously estimated. Adlie penguins ... to monitor and understand the effects of climate ... By using high-resolution satellite imagery, researchers from Stony ... a new method that permits regular monitoring of ...
(Date:7/9/2014)... an economy driven by methane, the primary component of natural ... production boom. It has poised the country as a top ... over just how climate-friendly it is, according to an article ... news magazine of the American Chemical Society. , In the ... when burned as a fuel to produce electricity, methane emits ...
Breaking Biology News(10 mins):New study finds that Adélie penguin population is on the rise 2New study finds that Adélie penguin population is on the rise 3
... discovered a new bacterium in an immune-compromised patient, according ... The bacterium belongs to the family Acetobacteraceae and includes ... used in industry, such as vinegar-making. "This is ... by any of the Acetobacteraceae," according to the article. ...
... new, more robust analysis of recently derived human gene ... in St Louis, shows three distinct major waves of ... and statistically refutes –strongly ?the 'Out of Africa' ... Homo sapiens left Africa 100,000 years ago and wiped ...
... develops when a mouse repeatedly experiences defeat by a ... a memory molecule in a brain circuit for social ... (NIH) National Institute of Mental Health (NIMH) have discovered. ... to welcome strangers in spite of repeated social defeat. ...
Cached Biology News:Scientists discover a new disease-causing bacterium in an immune-compromised patient 2New analysis shows three human migrations out of Africa 2Mice lacking social memory molecule take bullying in stride 2Mice lacking social memory molecule take bullying in stride 3
(Date:1/15/2014)... 2013 was a banner year of continued innovation ... continued independent research led by the team at Wake ... million grant from the Susanne Marcus Collins Foundation, had ... reviewed journal, Amy Grant highlighted Brainwave Optimization® in First ...
(Date:1/14/2014)... Carahsoft and CDS Federal Services have scheduled ... 2pm EST (11am PST), “Natural Language Processing: Converting Raw ... technology can turn raw, heterogeneous data into actionable knowledge ... online webinar will last approximately one hour. , Synopsis: ...
(Date:1/14/2014)... , Jan. 14, 2014 The largest ... research medicinal plants and therapeutic derivatives thereof has ... professionals, and researchers about the challenges of adulterated ... http://photos.prnewswire.com/prnh/20100430/DC95601LOGO ) The Society for ...
(Date:1/14/2014)... Rockville, MD (PRWEB) January 14, 2014 ... dedicated to developing innovative information technology solutions for ... other health care stakeholders, announced today the signing ... the US Food and Drug Administration (FDA). ...
Breaking Biology Technology:Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2
... bacteria are everywhere from the air we breathe and the ... majority are innocuous or even beneficial, and only a handful pose ... an unwanted intruder? , Research from the University of Wisconsin-Madison ... host. , A study appearing online this week in the ...
... local officials have taken steps to begin monitoring the ... a cutting-edge technology that has yet to be regulated ... the Cambridge (Mass.) Public Health Department recommended to the ... a better understanding of the nature and extent of ...
... will market the RAMP(R) cardiovascular product line in the United ... ... Roche Diagnostics and Response,Biomedical have entered into a partnership that will ... Biomedical,s new,point-of-care platform., The platform, the RAMP(R) 200 (Rapid Analyte ...
Cached Biology Technology:Symbiotic microbes induce profound genetic changes in their hosts 2Local officials move toward monitoring nanotechnologies 2Local officials move toward monitoring nanotechnologies 3Roche and Response Biomedical Corporation Aim to Reduce 'Vein-to-Brain' Time with New Point-of-Care Cardiac Tests 2Roche and Response Biomedical Corporation Aim to Reduce 'Vein-to-Brain' Time with New Point-of-Care Cardiac Tests 3
... This CLS number is a ... easily match Cornings product number. ... please order under the old ... customer service for assistance. ID ...
... The Yeast Oligo Microarray Kit (V2), ... to simultaneously characterize expression of many ... gene activity during important biological processes. ... representing 6,256 known ORFs from the ...
... software offers an intuitive, easy-to-use ... control, diverse data handling, and ... Comprehensive functions include data acquisition, ... management in both standalone and ...
... This CLS number is a ... easily match Cornings product number. ... please order under the old ... customer service for assistance. ID ...
Biology Products: