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Study reveals that financial conflicts of interest are associated with positive study outcomes
Date:5/27/2011

of reporting positive outcomes was only significant in one group for those authors receiving consulting fees/honoraria from the industry.

Study authors go on to state that "reporting of RCTs with such a high frequency of positive outcomes (72% in the overall study and approximately 90% for RCTs with authors receiving consultancy fees/honoraria or a research grant from Industry) raises ethical issues." Dr. Khan recommends that "an RCT should only be conducted if there is substantial uncertainty about the relative value of one treatment versus another."

The MEDLINE and Cochrane Central Register for Controlled Trials databases were searched for original, parallel-designed RA drug trials from 2002-3 and 2006-7 with clinical primary outcomes that randomly allocated patients to different treatment groups. Search terms included Rheumatoid Arthritis‟, Arthritis‟, Rheumatoid‟, with a limitation to Clinical Trials‟ and English‟. RCT outcome was defined as positive if a statistically significant result favoring the experimental intervention for primary outcome was found.


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Contact: Rory Berrie
rory.berrie@cohnwolfe.com
44-790-151-3297
European League Against Rheumatism
Source:Eurekalert

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