Navigation Links
Study reveals significance of second trimester markers for Down's syndrome
Date:1/30/2013

A new analysis has found that some second trimester markers for Down's syndrome that are detected by ultrasound are more telling than others. Published early online in Ultrasound in Obstetrics & Gynecology, the study's results will help adjust pregnant women's risks for having a child with the condition.

Screening for Down's syndrome is offered to all pregnant women, who start out with a background risk based on their age. Certain features detected during a second trimester ultrasound exam are potential markers for Down's syndrome, and they include dilated brain ventricles, absent or small nose bone, increased thickness of the back of the neck, an abnormal artery to the upper extremities, bright spots in the heart, 'bright' bowels, mild kidney swelling, and shortening of an arm bone or thigh bone.

To determine how these markers affect risk, Kypros Nicolaides, MD, of the Harris Birthright Research Centre for Fetal Medicine at King's College London in England, and his colleagues analyzed all published studies that reported results on second trimester markers for Down's syndrome between 1995 and 2012.

The researchers identified 48 studies, and they discovered that most single markers have only a small effect on modifying the odds for Down's syndrome. This finding could have important clinical implications because currently in the United States, when a marker such as a short arm or thigh bone is detected, women are told that they are at high risk of having a child with Down's syndrome. Dr. Nicolaides and his team found that a few markers do carry increased risks, though. Dilated brain ventricles, increased thickness of the back of the neck, and an abnormal artery to the upper extremities increase the risk by three- to four-fold, and an absent or small nose bone increases the risk by six- to seven-fold.

"The detection of any one of the findings during the scan should prompt the sonographer to look for all other markers or abnormalities," said Prof. Nicolaides. He added that the study also revealed that if a detailed second trimester ultrasound exam demonstrates the absence of all major markers, the risk of having a baby affected by Down's syndrome is reduced by more than seven-fold.

The findings indicate that the relative importance of ultrasound markers is very different from what has been previously assumed. Prof. Nicolaides noted that the results from this study will be incorporated in obstetric ultrasound scan software that adjusts women's risks for having a child with Down's syndrome.


'/>"/>

Contact: Amy Molnar
sciencenewsroom@wiley.com
Wiley
Source:Eurekalert

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2017)... Summary This report provides all the information ... partnering interests and activities since 2010. Download the ... Deals and Alliance since 2010 report provides an in-depth ... world,s leading life sciences companies. On demand ... of the most up to date deal and company ...
(Date:2/28/2017)... 2017 News solutions for biometrics, bag drop ... ... 14 to 16 March, Materna will present its complete end-to-end ... travel is a real benefit for passengers. To accelerate the ... passenger touch point solutions to take passengers through the complete ...
(Date:2/22/2017)... , Feb. 22, 2017 With the ... ABI Research identifies four technologies that innovative and ... secure significant share in the changing competitive landscape: ... passive authentication.   "Companies can no ... to security," says Dimitrios Pavlakis , Industry ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... March 29, 2017  Vermillion, Inc. (NASDAQ: VRML), ... reported on its results for the fourth quarter ... "2016 marked a pivotal year for us ... inclusion, international distribution agreements, major reimbursement progress with ... payer agreements. In addition we cleared our 2 ...
(Date:3/29/2017)... 29, 2017 WuXi Biologics, a leading ... to biologics and a WuXi AppTec Affiliate, today ... Best Bioprocessing Excellence Award from IMAPAC, a leading ... aims to recognize outstanding leaders and trend-setters of ... bioprocessing and biomanufacturing experts in the industry, along ...
(Date:3/29/2017)... LINCOLN, Mass. , March 29, 2017 ... industry-leader in applying mechanistic modeling to drug ... of their collaboration with Zymeworks Inc. for ... drug conjugate therapeutics intended for the treatment ... has supported Zymeworks previously for GLP toxicology ...
(Date:3/29/2017)... ... March 29, 2017 , ... Cancer diagnostics and pathology workflow ... at the Association of Community Cancer Centers (ACCC) 43rd Annual Meeting, CANCERSCAPE ... unites key stakeholders from leading national organizations to share insights on how value-based ...
Breaking Biology Technology: