Navigation Links
Study reveals new role for RNA interference during chromosomal replication
Date:10/16/2011

Cold Spring Harbor, N.Y. At the same time that a cell's DNA gets duplicated, a third of it gets super-compacted into repetitive clumps called heterochromatin. This dense packing serves to repress or "silence" the DNA sequences withinwhich could wreck the genome if activatedas well as regulate the activity of nearby genes. When the cell divides, the daughter cells not only inherit a copy of the mother cell's DNA, but also the exact pattern in which that DNA is clumped into heterochromatin.

This "epigenetic" mode of inheritanceinformation not transmitted through the DNA code itself but by the way in which it is packagedhas long been investigated by Cold Spring Harbor Laboratory Professor and HHMI-GBMF Investigator Rob Martienssen. In a landmark study that was hailed as one of the breakthroughs of the year by Science magazine in 2002, Martienssen and his colleagues showed that the inheritance of heterochromatin depends on a set of mechanisms broadly defined as RNA interference (RNAi).

In a new study that appears online in Nature on October 16, Martienssen's team, including investigators from the Pasteur Institut in Paris and the University of Salamanca in Spain, describes a new role for RNAi, one that allows the DNA replication process itself to progress smoothly without resulting in DNA damage.

DNA is normally coiled around proteins called histones, which when chemically modified at specific locations, aggregate into dense arrays to form heterochromatin. Martienssen and others had previously found that RNAi guides this histone modification process, which occurs at the same time in the cell cycle when DNA is being duplicated.

In this RNAi-guided process, an enzyme called polymerase II copies or "transcribes" specific regions of DNA into RNA molecules, and somehow this modifies histones in those exact regions, thereby creating heterochromatin. These heterochromatic regions, however, alternate with so-called "origins of replica
'/>"/>

Contact: Hema Bashyam
bashyam@cshl.edu
516-367-6822
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Method of studying roots rarely used in wetlands improves ecosystem research
2. Southampton scientists herald significant breakthrough in study of chlamydia
3. Einstein College of Medicine given $6.7 million to study congenital heart defect genetics
4. National Science Foundation selects University of Colorado Denver team to study city sustainability
5. Worms among first animals to surface after K-T extinction event, CU-led study finds
6. Researchers study agings effect on the brain
7. Cleveland Clinic study discovers new targets for treating inflammatory, autoimmune diseases
8. Gray jays winter survival depends on food storage, study shows
9. Study tracks mutations causing CDA II back to the Roman Empire
10. New data-mining effort launched to study mental disorders
11. Study suggests childrens food choices are affected by direct advertising and parental influence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... , June 25, 2015 ... of the "Next Generation Biometrics Market by Application, ... report to their offering. The next ... by 2020, at a CAGR of 17.9% between 2015 ... leading application for the market. Safran SA ...
(Date:6/30/2015)... , June 30, 2015 To bolster its efforts ... HYPR Corp. announced today the addition of two new team ... as board advisor and David Raviv will act ... underscore HYPR Corp.,s commitment to providing the most secure solutions ... Sirota co-founded Layer 7 Technologies, a provider of security ...
(Date:6/29/2015)... 24, 2015 Research and ... "Latin America Biomedical Sensors Market - Growth, Trends ... The Latin America Biomedical Sensors market is estimated ... 2.04% over the period 2014-2020 The near ... the genetic formulation of each individual. These sensors can ...
Breaking Biology News(10 mins):Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 2HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 3Latin America Biomedical Sensors Market Report 2015-2020 2
... bacteria of its ability to resist an antibiotic in ... health crisis. Rice environmental engineer Pedro Alvarez ... the Pseudomonas aeruginosa microorganism to resist the antibiotic medication ... Over 120 generations, the starving bacteria chose ...
... Bethesda, MD The Federation of American Societies for ... the Science Research Conference (SRC): Melatonin Biology: Actions & ... Biology: Actions & Therapeutics is an important and unique ... as a cytoprotective molecule and a physiological marker of ...
... behave differently. However, that difference isn,t taken into account ... children from chemical exposure, according to Cheryl Rosenfeld, associate ... Bond Life Sciences Center. A series of experiments by ... A (BPA) on later reproductive-associated behaviors using a socially ...
Cached Biology News:Lack of energy an enemy to antibiotic-resistant microbes 2Lack of energy an enemy to antibiotic-resistant microbes 3Bisphenol A affects sex-specific reproductive behaviors in a monogamous animal species 2
(Date:8/3/2015)... Medical, Inc. (Nasdaq: AEMD ), the pioneer in ... announced that it will host its First Quarter Fiscal ... 13, 2015 at 4:30 p.m. Eastern Time. ... fiscal 2016 first quarter results.  A recorded version of ... the call at the Investor Relations portion of the ...
(Date:8/3/2015)... - RepliCel Life Sciences Inc. (TSX.V: RP) (OTCQB: REPCF), a ... autologous cell therapies, announced today that RepliCel,s CEO, David ... in Minneapolis, Minnesota on August 5 ... highlight RepliCel,s 18-month milestones including CE Mark for its RCI-02 ... clinical data from both RCT-01 (tendon) and RCS-01 (skin) clinical ...
(Date:7/31/2015)... KONG , July 31, 2015 China ... China,s leading provider of cord ... stem cell storage services, today announced that the Company ... the U.S. Securities and Exchange Commission. The filed Form ... ended March 31, 2015. The Form 20-F can be ...
(Date:7/30/2015)... , July 30, 2015   GenoSpace ... for the interpretation and analysis of genomic and ... Fischer has joined the company as Vice ... - http://photos.prnewswire.com/prnh/20150730/250931 "GenoSpace ... to integrate, interpret, analyze and explore complex sets ...
Breaking Biology Technology:Aethlon Medical To Host First Quarter Fiscal 2016 Investor Call on August 13, 2015 2RepliCel Presenting at InvestMNT Investor Conference in Minneapolis 2China Cord Blood Corporation Files Its Annual Report on Form 20-F 2GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2
... , ... Real-time in situ FTIR analysis has become a standard tool ... allows a more thorough understanding of reactions during the development and scale-up ... the Development of Batch and Continuous Chemical Processes Using Real-Time In Situ ...
... , ... Canadian Therapy Uses Energy Physics To Target Tissues Affected by Osteoarthritis. Physics and Biology ... ... announced today that its home-use medical device, the MyPhield Arthritis Therapy Cushion that naturally ...
... Nov. 3 ISTA Pharmaceuticals, Inc. (Nasdaq: ISTA ... September 30, 2009. ISTA reported net revenue of $32.0 ... 47% increase over net revenue for the three months ended ... three months ended September 30, 2009 is $1.2 million associated ...
Cached Biology Technology:Development of Batch and Continuous Chemical Processes Using Real-Time In Situ FTIR Analytics as a Process Analytical Technology (PAT) Tool 2New Technology Now Available In Canada For Osteoarthritis 2ISTA Pharmaceuticals Reports Third Quarter 2009 Financial Results 2ISTA Pharmaceuticals Reports Third Quarter 2009 Financial Results 3ISTA Pharmaceuticals Reports Third Quarter 2009 Financial Results 4ISTA Pharmaceuticals Reports Third Quarter 2009 Financial Results 5ISTA Pharmaceuticals Reports Third Quarter 2009 Financial Results 6ISTA Pharmaceuticals Reports Third Quarter 2009 Financial Results 7ISTA Pharmaceuticals Reports Third Quarter 2009 Financial Results 8ISTA Pharmaceuticals Reports Third Quarter 2009 Financial Results 9