Navigation Links
Study reveals link between oil spill exposure and hematologic and hepatic toxicity
Date:9/16/2013

Philadelphia, PA, September 17, 2013 A new study reports that workers exposed to crude oil and dispersants used during the Gulf oil spill cleanup display significantly altered blood profiles, liver enzymes, and somatic symptoms compared to an unexposed control group. Investigators found that platelet counts were significantly decreased in the exposed group, while both hemoglobin and hematocrit levels were notably increased. Their findings, reported in The American Journal of Medicine, suggest that oil spill cleanup workers are at risk for developing hepatic or blood-related disorders.

In April 2010, Deepwater Horizon, an offshore drilling rig owned by British Petroleum (BP) exploded, spewing over 200 million gallons of oil into the Gulf of Mexico. In order to break down the oil slick, BP used nearly 2 million gallons of dispersants like COREXIT, and an estimated 170,000 workers participated in the cleanup effort. Currently, COREXIT is banned in the United Kingdom because of its potential risk to cleanup workers.

While other studies have identified a relationship between oil spills, dispersants, and human health, this new research from the University Cancer and Diagnostic Centers, Houston, TX, led by G. Kesava Reddy, PhD, MHA, and Mark A. D'Andrea, MD, FACRO, focuses primarily on the link between oil spill exposure and hematologic and hepatic functions in subjects who had participated in the oil spill cleanup operation. The investigators looked at a total of 247 subjects between January 2010 and November 2012, with 117 subjects identified as exposed to the oil spill and dispersants by participating in the cleanup over the duration of three months. The unexposed control group of 130 subjects was comprised of people living at least 100 miles away from the Gulf coast of Louisiana.

Using medical charts, demographic and clinical records, the team reviewed specific data points such as white blood cell (WBC) counts, platelet counts, hemoglobin, hematocrit, blood urea nitrogen (BUN), creatinine, serum beta-2 microglobulin, alkaline phosphatase (ALP), aspartate amino transferase (AST), and alanine amino transferase (ALT) for both groups.

While no significant differences were noted in the WBC counts of the two groups, the study did find that platelet counts were notably decreased in the oil spill exposed group. Also, BUN and creatinine levels were substantially lower in the exposed group, while hemoglobin and hematocrit levels were increased compared to the unexposed subjects. Furthermore, considered indicators of hepatic damage, the serum ALP, AST, and ALT levels in the exposed subjects were also elevated, suggesting that the exposed group may be at a higher risk for developing blood-related disorders.

"Phosphatases, amino transferases, and dehydrogenases play critical roles in biological processes. These enzymes are involved in detoxification, metabolism, and biosynthesis of energetic macromolecules that are important for different essential functions," says lead investigator G. Kesava Reddy. "Alterations in the levels of these enzymes result in biochemical impairment and lesions in the tissue and cellular function."

Participants also reported somatic symptoms, with headache reported most frequently, followed by shortness of breath, skin rash, cough, dizzy spells, fatigue, painful joints, night sweats, and chest pain. "The health complaints reported by those involved in oil cleanup operations are consistent with the previously reported studies on major oil spills. However, the prevalence of symptoms appears to be higher in the present study compared with the earlier findings of other investigators," added Dr. Reddy.

The investigators acknowledge that the lack of pre-disaster health data on the subjects involved in the study is the greatest limiting factor; however, the data collected have shown significant health effects on the cleanup workers.

"To our knowledge, no previous study has explored the effects of the oil spill specifically assessing the hematological and hepatic functions in oil spill cleanup workers," explains Dr. Reddy. "The results of this study indicate that oil spill exposure appears to play a role in the development of hematologic and hepatic toxicity. However, additional long-term follow-up studies are required to understand the clinical significance of the oil spill exposure."


'/>"/>

Contact: Jane Grochowski
ajmmedia@elsevier.com
406-542-8397
Elsevier Health Sciences
Source:Eurekalert

Related biology news :

1. Study recommends strategies for improved management of fresh market spinach
2. Novelty of eco-friendly bamboo garments lures consumers -- if the price is right, Baylor study shows
3. ASU football program is first collegiate partner in TGen-Riddell concussion detection study
4. A phone call can change your life: Study finds
5. Study details paired risk factors in preeclampsia
6. African-American study identifies 4 genetic variants associated with blood pressure
7. Therapy slows onset and progression of Lou Gehrigs disease, study finds
8. Cytos Biotechnology Presents Additional Results From Phase 2a Study of CYT003 for the Treatment of Allergic Asthma
9. LSUHSC researchers develop new system to better study behavior, cell function
10. 400-year study finds Northeast forests resilient, changing
11. UCSF receives $4.5M to study value of gene sequencing in newborns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2016)...   EyeLock LLC , a market leader of ... an IoT Center of Excellence in Austin, ... of embedded iris biometric applications. EyeLock,s iris ... security with unmatched biometric accuracy, making it the most ... EyeLock,s platform uses video technology to deliver a fast ...
(Date:5/9/2016)... 9, 2016 Elevay is currently ... expanding freedom for high net worth professionals seeking travel ... globally connected world, there is still no substitute for ... duplicate sealing your deal with a firm handshake. This ... taking advantage of citizenship via investment programs like those ...
(Date:4/28/2016)... SAN FRANCISCO and BANGALORE, India ... part of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... service provider, today announced a global partnership that ... convenient way to use mobile banking and payment services. ... Mobility is a key innovation area for financial services, but ...
Breaking Biology News(10 mins):
(Date:5/23/2016)... ... May 23, 2016 , ... PrecisionAg® ... Farming in 2017 and Beyond. The paper outlines the key trends that are ... industry. , “We’ve witnessed a lot of highs and lows as the precision ...
(Date:5/23/2016)... May 23, 2016 Oxitec CEO ... at 10:15 a.m. ET before the United States House ... engineered mosquitos can play in controlling the spread of the ... Zika virus.      (Logo: http://photos.prnewswire.com/prnh/20150630/227348 ) ... with a self-limiting gene. Trials in Brazil ...
(Date:5/23/2016)... ... May 23, 2016 , ... RoviSys, a leading independent ... Aurora, Ohio, has broken ground on a new building in Holly Springs, NC. ... this new location solidifies a commitment to business in the region. The new ...
(Date:5/22/2016)... ... ... Doctors in Rome say micronutrients found in certain foods have the potential ... just posted an article on the new research. Click here to read it ... Translational Medicine evaluated more than 150 studies on polyphenols in cancer for their report ...
Breaking Biology Technology: