Navigation Links
Study reveals how viruses collectively decide the fate of a bacterial cell
Date:9/15/2008

A new study suggests that bacteria-infecting viruses called phages can make collective decisions about whether to kill host cells immediately after infection or enter a latent state to remain within the host cell.

The research, published in the September 15 issue of the Biophysical Journal, shows that when multiple viruses infect a cell, this increases the number of viral genomes and therefore the overall level of viral gene expression. Changes in viral gene expression can have a dramatic nonlinear effect on gene networks that control whether viruses burst out of the host cell or enter a latent state.

"What has confounded the virology community for quite some time is the observation that the cell fate of a bacteria infected by a single virus can be dramatically different than that infected by two viruses," said Joshua Weitz, an assistant professor in the School of Biology at the Georgia Institute of Technology. "Our study suggests that viruses can collectively decide whether or not to kill a host, and that individual viruses 'talk' to each other as a result of interactions between viral genomes and viral proteins they direct the infected host to produce."

To study viral infections, Weitz teamed with postdoctoral fellow Yuriy Mileyko, graduate student Richard Joh and Eberhard Voit, who is a professor in the Wallace H. Coulter Department of Biomedical Engineering, the David D. Flanagan Chair Georgia Research Alliance Eminent Scholar in Biological Systems and director of the new Integrative BioSystems Institute at Georgia Tech.

Nearly all previous theoretical studies have claimed that switching between "lysis" and "latency" pathways depends on some change in environmental conditions or random chance. However, this new study suggests that the response to co-infection can be an evolvable feature of viral life history.

For this study, the researchers analyzed the decision circuit that determines whether
'/>"/>

Contact: Abby Vogel
avogel@gatech.edu
404-385-3364
Georgia Institute of Technology Research News
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. UC Riverside botanist to study role of plants in southern Californias drought
2. Book breaks new ground in the study of economics and forest threats management
3. As Andean glacier retreats, tiny life forms swiftly move in, CU-Boulder study shows
4. Rhode Island Hospital study finds link between obesity, type 2 diabetes and neurodegeneration
5. What a sleep study can reveal about fibromyalgia
6. Biological invasions increasing due to freshwater impoundments, says CU-Boulder study
7. Landmark study opens door to new cancer, aging treatments
8. Study shows more genes are controlled by biological clocks
9. Armored fish study helps strengthen Darwins natural selection theory
10. Study says eyes evolved for X-Ray vision
11. Study of islands reveals surprising extinction results
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study reveals how viruses collectively decide the fate of a bacterial cell
Study reveals how viruses collectively decide the fate of a bacterial cell
(Date:1/8/2009)... That pesky buzz of a nearby mosquito is the soun...t a new Cornell study reports that males and femal...e a harmonic duet just before mating., Cornell en...osquitoes (Aedes aegypti), which can spread such d...ustically with each other when the two are within ...
(Date:1/8/2009)... published in the international journal Neurobiol...at being physically fit helps the brain function a...ion for Medical Research Senior Scholar, Poulin fi...the brain, and, as a result, cognitive abilities. ...or for stroke and dementia," says Poulin, a scient...
(Date:1/8/2009)...e is available in Spanish . , Anti-inflamm...matory processes, but also those that do not. This...nflammatory drugs which affect healthy cells. With...he Basque Country is working on analogues of the C...tory pharmaceutical drugs are available: steroids ...
(Date:1/8/2009)...Y. New tires allow race cars to take tight turns ...ies similar advantages: They are not necessary for...turns to evade predators. , "To escape a predator...ore erratic," said Tom Eisner, a world authority o...acob Gould Schurman Professor Emeritus of Chemical...
Breaking Biology News(10 mins):Mosquitoes create harmonic love song before mating, study finds 2Research finds older women who are more physically fit have better cognitive function 2The quest for specific anti-inflammatory treatment 2The quest for specific anti-inflammatory treatment 3Hind wings help butterflies make swift turns to evade predators, study finds 2MS patients have higher spinal fluid levels of suspicious immune molecule 26853 1MS patients have higher spinal fluid levels of suspicious immune molecule 26853 2MS patients have higher spinal fluid levels of suspicious immune molecule 26853 3Experiment demonstrates 110 years of sustainable agriculture 5115 1Experiment demonstrates 110 years of sustainable agriculture 5115 2CPC of America Inc to Explore Strategic Alternatives 3B Appoints FTI Capital Advisors to Assess Potential Opportunities 7966 1CPC of America Inc to Explore Strategic Alternatives 3B Appoints FTI Capital Advisors to Assess Potential Opportunities 7966 2Commercial aquatic plants offer cost effective method for treating wastewater 5113 1Commercial aquatic plants offer cost effective method for treating wastewater 5113 2
...ation is passed from parents to offspring via sper...elled organisms, such as yeast, the genes can be p...productive strategies, major physical changes occu...ated and then halved on the way to the production ...rocess, the material ?called chromatin, the substr...
...sease Laboratory at Columbia University,s Mailman ...ontrol and Prevention, and the Caribbean Primate R...which the Filoviruses, Ebola and Marburg, cause di...ce in Filoviruses that results in the rapid depres... December 2006 issue of The FASEB Journal. Using ...
...ion with high levels of the virus associated with ...h as 27 times, according to a study published in t...markers & Prevention. , Anthony Gunnell, a me...agues at the Karolinska Institutet in Stockholm re...e cervical cancer in situ (the most common type) a...
...ful animal parasite on earth: It infects hundreds... half of humanity. Its unusual ability to overcom...cing inside such a wide range of creatures has lo...he Stanford University School of Medicine have id...ty to thrive. , The findings will be published in ...
Other Biology News:Single molecular 'mark' seen as pivotal for genome compaction in spores and sperm 2Researchers discover key mechanism by which lethal viruses Ebola and Marburg cause disease 2High HPV concentrations combined with smoking significantly raise risks of cervical cancer 2High HPV concentrations combined with smoking significantly raise risks of cervical cancer 3Stanford discovery may help predict when toxoplasma can be deadly 2Stanford discovery may help predict when toxoplasma can be deadly 3
(Date:1/8/2009)...ednesday, January 14, 2009 at 9:30 a.m. PT , ,... ARCA biopharma, Inc., a...targeted therapies for heart failure and other car...NUVO ) today announced that Richard Brewer, ARCA,s...nt at the 27th Annual JPMorgan Healthcare Conferen...
(Date:1/8/2009).../ -- Karolinska Development AB (publ),recently cl...EK 147 million,(USD 19 million). Its major shareh... AP-fonden; Ostersjostiftelsen; Nasudden; Foundati...heir share of the new issue, while new investors,...opment was advised by EFG,Bank AB. , The n...
(Date:1/8/2009)...Call/ -- Arena Pharmaceuticals, Inc. (Nasdaq: AR... to present at the 27th Annual J.P. Morgan Healthc...cific Time (6:00 p.m. Eastern Time) at the Westin ...na,s President and Chief Executive Officer, is sch...uding its clinical development and discovery progr...
(Date:1/8/2009)...to Exceed $8 Billion Globally by 2012 , , VENTU...c., developer of LifeShirt(R), a continuous, integ... system, announced today that president and chief ... Biotech Showcase on Wednesday, January 14, 2009 a...isco. Mr. Baker will discuss VivoMetrics, role in ...
Breaking Biology Technology:ARCA biopharma to Present at 27th Annual JPMorgan Healthcare Conference 2ARCA biopharma to Present at 27th Annual JPMorgan Healthcare Conference 3ARCA biopharma to Present at 27th Annual JPMorgan Healthcare Conference 4ARCA biopharma to Present at 27th Annual JPMorgan Healthcare Conference 5Karolinska Development Closes Fully Subscribed New Share Issue 2Karolinska Development Closes Fully Subscribed New Share Issue 3Arena Pharmaceuticals to Present at the 27th Annual J.P. Morgan Healthcare Conference 2Arena Pharmaceuticals to Present at the 27th Annual J.P. Morgan Healthcare Conference 3VivoMetrics to Present at the 2009 Biotech Showcase 2VivoMetrics to Present at the 2009 Biotech Showcase 3
...tiporator , , , , , , ,...ocol , Protocol No. 4308 915.038 11/1..., , , , , , ..., , , Transfection wi... 2 O), , , Electrop...
...tiporator , , , , , , ,...ocol , Protocol No. 4308 915.031 12/1..., , , , , , ...ary, , , Transfect... 2 O), stable transfection, , ,...
...tiporator / Electroporator 2510 , , , ... Transformation Protocol , Protoco..., , , , , , , , ... Brucella abortus, , , ...tive, , , Molecules...
...tiporator , , , , , , ,...ocol , Protocol No. 4308 915.042 11/2..., , , , , , ...ls, , , Transfectio...ed H 2 O), , , Elec...
Other Biology Technology:COS-1 2CHO 2Brucella abortus 2B16 2
Microlite 2+ Plate, round bottom; an irradiated, high binding surface with enhanced dynamic range, extra high reflectivity and minimal cross talk for low signal luminescent reactions.
Immulon 4 HBX 1x12 Strip, flat bottom; high binding extra surface with special resin and irradiation, offers maximum protein uptake.
SkanIt™ Software is the ultimate tool for both microplate reader control and data handling. There are two editions of SkanIt Software available; a Research Edition for scientists working in life
Chicken polyclonal to UCK2 ( Abpromise for all tested applications). Antigen: Full length protein, corresponding to amino acids 1-261 of Human UCK2 Entrez Gene ID: 7371 Swiss Protein ID:
Biology Products: