Navigation Links
Study reveals how the world's first drug for amyloid disease works
Date:5/29/2012

ed interesting biochemical stabilization, Wilson's team analyzed its structure. "By the end, we had determined more than 30 small molecule stabilizerTTR structures, in an effort to generate tafamidis and identify the molecular interactions that lead to stabilization of the natural TTR tetramer," said Stephen Connelly, a Wilson laboratory staff scientist who performed these structural studies and who was a co-author the paper.

The small molecule benzoxazole, tafamidis, that ultimately entered clinical trials was optimized for several criteria, including its ability to stabilize the TTR tetramer's weakest seam. "We found that one end of the tafamidis structure fits neatly into the tetramer's hydrophobic thyroxine-binding pocket, while at the other end it binds to nearby polar amino acids, both types of interactions bridging or stabilizing the two halves of the tetramer," Connelly said. The drug's stabilizing force greatly reduces the rate at which these tetramers come apart, and in so doing greatly reduces the rate of amyloid formation.

Tafamidis is considered an "orphan" drug because its initial intended treatment population is the relatively small polyneuropathy population. However, even wild-type TTR forms amyloid in 10 to 20 percent of the growing elderly populationleading to cardiomyopathy. Thus, this condition, and drugs such as tafamidis that can treat it, could be of growing interest to the pharmaceutical industry.


'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

0

GOOD

Page: 1 2 3 4

Related biology news :

1. Study finds emissions from widely used cookstoves vary with use
2. NIH-funded study examines use of mobile technology to improve diet and physical activity behavior
3. Study provides new insights into structure of heart muscle fibers
4. U of M study finds titan cells protect Cryptococcus
5. Variations of a single gene can lead to too much or too little growth, study shows
6. Yale study concludes public apathy over climate change unrelated to science literacy
7. T cells hunt parasites like animal predators seek prey, a Penn Vet-Penn Physics study reveals
8. Study finds voter genetics may predict election outcomes
9. Army study: DNA vaccine and duck eggs protect against hantavirus disease
10. New HealthFocus® International Study Reveals Five Very Different Weight Management Consumers
11. New study shows how nanotechnology can help detect disease earlier
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study reveals how the world's first drug for amyloid disease works
(Date:5/16/2013)... FASEB MARC (Maximizing Access to Research Careers) Program ... Society for Developmental Biology (SDB) 72nd Annual Meeting ... awards are meant to promote the entry of ... the mainstream of the basic science community and ... the SDB 2013 Annual Meeting. , Awards are ...
(Date:5/16/2013)... layer lining the body,s blood vessels, is extremely ... thickness, this super-tenuous structure routinely withstands blood flow, ... a unique and highly dynamic barrier that maintains ... body,s circulatory system. , It,s also extremely adaptable. ... breached to enable immune cells to reach ...
(Date:5/16/2013)... fossils that are about 23 million years old ... the gobioid order, one of the most species-rich ... led by paleontologist Professor Bettina Reichenbacher from the ... of Earth and Environmental Sciences at Ludwig-Maximilians-Universitaet (LMU) ... analysis of fish fossils which they assign to ...
Breaking Biology News(10 mins):Endothelium, heal thyself 2Endothelium, heal thyself 3Endothelium, heal thyself 4Paleontology: The eloquence of the otoliths 2Paleontology: The eloquence of the otoliths 3
... usually a joyous event, but when a child is born too ... baby and steep medical bills for the family. To address this, ... new system to pick up very early signs that a woman ... a pregnancy is 40 weeks, while babies born before 37 weeks ...
... 21 July, 2010 (Vienna, Austria) -- Can HIV infection ... persistence in infected persons was the topic of a ... eve of AIDS 2010, the biennial international conference of ... "Towards a Cure: HIV Reservoirs and Strategies to Control ...
... a new solution to an old debate on why species hybrids ... be published online next week in the online open access journal ... "noise" caused by a surprising degree of variation in gene activity ... that when species hybridise, some of the variation in gene activity ...
Cached Biology News:Students design early labor detector to prevent premature births 2Students design early labor detector to prevent premature births 3Students design early labor detector to prevent premature births 4Top scientists tackle the issue of HIV persistence 2What causes hybrid vigor? 2
(Date:5/17/2013)... May 17, 2013 •    First of its ... for sustainability ,     New facility will help solve ... , Syngenta unveiled its new crop research ... company’s RTP Innovation Center. The first of its kind, ... simulate any agricultural climate and precisely measure plant inputs ...
(Date:5/17/2013)... Calif. , May 17, 2013 /PRNewswire-iReach/ -- ... has been reached with Switzerland ... of anti-infective human monoclonal antibody (mAb) products, and ... human mAb products for treatment of infections by ... Staphylococcus aureus , Pseudomonas aeruginosa , ...
(Date:5/17/2013)... Frederick, MD (PRWEB) May 17, 2013 ... release of ezColony version 4.1, a versatile refinement ... world-class premier software solution, improves its advanced methodical ... animal facilities with ezColony 4.1. The network-based platform ... to conduct effective research. While continuing to emphasize ...
(Date:5/16/2013)... The Stirling Ultracold Model SU780U ... Athens, OH, USA, won the Outstanding New Product Award ... for Biological and Environmental Repositories (ISBER) at their annual ... product annually, recognizes the company’s development and introduction of ... The award was presented to Global Cooling’s CEO Neill ...
Breaking Biology Technology:Syngenta Opens Unique $72 Million Advanced Crop Lab 2Syngenta Opens Unique $72 Million Advanced Crop Lab 3Aridis Pharmaceuticals Announces Acquisition of Monoclonal Antibody Products and Technologies From Kenta Biotech 2Aridis Pharmaceuticals Announces Acquisition of Monoclonal Antibody Products and Technologies From Kenta Biotech 3RURO Introduces ezColony 4.1 – The Versatile Transgenic Animal Colony Management Software 2Stirling Ultracold Ultra-Low Freezer Wins 2013 Outstanding New Product Award at International Biorepository Conference, Sydney, Australia 2
... Eisai Corporation of North,America and its U.S. subsidiary, ... and Drug Administration (FDA) Advisory Committee on Anesthetic,and ... 3 in favor (with one,abstention) of approval of ... agent for sedation in adult patients,undergoing diagnostic or ...
... WALTHAM, Mass., May 7 Interleukin Genetics,Inc. (AMEX: ... conference call and,webcast on Wednesday, May 14, 2008 at ... financial results and provide an update on recent,corporate developments., ... or 719-325-4869,(international). The live webcast will be available on ...
... and Other ... to Nektar, SAN CARLOS, Calif., May 7 ... U.S. Patent and Trademark Office,has issued Patent No. 7,368,102, ... Inhalation Powder (TIP) and other,aminoglycoside antibiotics delivered via Nektar,s ...
Cached Biology Technology:FDA Advisory Committee Votes in Favor of Approval of Fospropofol Disodium Injection for Sedation 2FDA Advisory Committee Votes in Favor of Approval of Fospropofol Disodium Injection for Sedation 3Interleukin Genetics Announces Conference Call and Webcast to Discuss First Quarter 2008 Business Results 2Nektar Receives Patent Covering Pulmonary Targeted Antibiotics 2Nektar Receives Patent Covering Pulmonary Targeted Antibiotics 3
MAb to Transferrin Dry Ice: No Preservative: NaN3 Availability When Not in Inventory: 14-21 Business Days...
Rabbit polyclonal to IRS1 (phospho S636) ( Abpromise for all tested applications). entrezGeneID: 3667 SwissProtID: P35568...
Leucine-rich repeat-containing G-protein coupled receptor 4...
Rabbit polyclonal to MDM2 (phospho S185) ( Abpromise for all tested applications). entrezGeneID: 4193 SwissProtID: Q00987...
Biology Products: