Navigation Links
Study reveals how the world's first drug for amyloid disease works
Date:5/29/2012

uded in the TTR aggregate distribution are amyloid fibrilsprotein stacks made from millions of TTR monomersalthough researchers suspect that smaller, shorter-lived pre-amyloid aggregates do more direct damage to nerve cells and nerve fibers.

The early onset TTR amyloidoses are caused by inherited TTR mutations that weaken the tetramers' ability to stick together, producing monomers more likely to aggregate into amyloids and other aggregate structures. Fortunately, the TTR tetramer, which is the backup carrier of the thyroid hormone thyroxine through the bloodstream, has two unoccupied thyroxine-binding sites along its longest and weakest seam. Kelly and his colleagues designed tafamidis to grab either of these thyroxine-binding sites, in a way that bridges the seam and helps keep the tetramer from coming apart.

A Stabilizing Influence

The newly published molecular and structural data show that tafamidis does indeed stabilize TTR tetramers, under normal physiological conditions in the bloodstream and even under abnormal conditions when they would be much more likely to fall apart and reassemble as amyloids. Tafamidis has this stabilizing effect on tetramers of the normal "wild-type" TTR protein as well as on those made from disease-associated mutant and wild type TTR subunits.

"There are more than a hundred TTR mutations that cause amyloidosis, but the vast majority of those TTRs are capable of being bound by tafamidis and held in the natural tetramer state," said Kelly.

Throughout the development of tafamidis-type compounds, Kelly and his colleagues collaborated with the Scripps Research laboratory of Ian A. Wilson, who is Hansen Professor of Structural Biology and a member of the Skaggs Institute at Scripps Research. The Wilson laboratory specializes in the use of X-ray crystallography to determine the atomic structures of interacting proteins. Whenever a small molecule stabilizer of TTR was generated that afford
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Study finds emissions from widely used cookstoves vary with use
2. NIH-funded study examines use of mobile technology to improve diet and physical activity behavior
3. Study provides new insights into structure of heart muscle fibers
4. U of M study finds titan cells protect Cryptococcus
5. Variations of a single gene can lead to too much or too little growth, study shows
6. Yale study concludes public apathy over climate change unrelated to science literacy
7. T cells hunt parasites like animal predators seek prey, a Penn Vet-Penn Physics study reveals
8. Study finds voter genetics may predict election outcomes
9. Army study: DNA vaccine and duck eggs protect against hantavirus disease
10. New HealthFocus® International Study Reveals Five Very Different Weight Management Consumers
11. New study shows how nanotechnology can help detect disease earlier
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study reveals how the world's first drug for amyloid disease works
(Date:1/22/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) a ... the recent success of the Wocket™ smart wallet at CES 2015 in ... was named as one of the "11 Hot Products at CES" in ... At CES So Far" by Newseveryday.com and "The top 10 gadgets from ...
(Date:1/22/2015)... 22, 2015 Research and Markets ( ... "Global Wearable Technologies Market and Applications, Opportunities, ... and Forecast 2014-2020" report to their offering. ... devices that can be worn on the user,s ...
(Date:12/22/2014)... Conn. , Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile commerce market, ... Apollo Robbins for the 2015 International CES debut ... Apollo Robbins will be at the NXT-ID booth January ...
Breaking Biology News(10 mins):CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4
... fruit and vegetable crops rely on pollination by bees and ... those species is uncertain. Now researchers from North Carolina State ... performance of pollinator species in order to determine which species ... "Widespread concerns over the fate of honey bees and other ...
... Bumblebees look cute. They have a thick fur, fly ... wasps. They are very much appreciated by farmers as ... crisis-stricken honeybee populations, the buff-tailed bumblebee, Bombus terrestris ... the pollination of fruit and vegetable crops both inside ...
... London, December 9, 2013 The world is still underfunding ... in ensuring comprehensive and equitable health care for all, and ... gender equality fit in? Papers in the latest ... recent history of sexual and reproductive health and rights at ...
Cached Biology News:Researchers develop system for assessing how effective species are at pollinating crops 2Peaceful bumblebee becomes invasive 2Peaceful bumblebee becomes invasive 3Reproductive Health Matters announces publication of its latest themed issue: New development paradigm 2
(Date:1/22/2015)... NEW BRUNSWICK , Nueva Jersey , 22 ... Award for Biomedical Research abre hoy su llamada ... las personas cuya investigación científica ha hecho, o tiene ... de la salud humana. Las nominaciones se aceptarán hasta ...
(Date:1/22/2015)... 2015   GenoSpace , a precision medicine software company that ... broad use of genomic, imaging and other biomedical data in ... Michelle Munson , CEO of Aspera, an IBM Company, to ... http://photos.prnewswire.com/prnh/20150122/170713 "We are pleased to ...
(Date:12/24/2014)... SPRING, Md. , Dec. 24, 2014  United Therapeutics ... Medtronic, Inc. (NYSE: MDT ) has submitted ... Drug Administration (FDA) for the use of Medtronic,s SynchroMed ... newly developed catheter) for use with United Therapeutics, Remodulin ...
(Date:12/24/2014)... 2014   BioLife Solutions , Inc. (NASDAQ: BLFS ... grade hypothermic storage and cryopreservation freeze ... and tissues  ("BioLife" or the "Company"), today announced that it ... 4, 2015 (the "Annual Meeting"). Because the expected ...
Breaking Biology Technology:El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4GenoSpace Expands Board with Appointment of Michelle Munson 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4BioLife Solutions Sets Date for Annual Meeting of Stockholders 2
... . Researchers at Oak Ridge National Laboratory ... wire in lengths up to 15 feet. Friction-stir, which ... uses the heat from a spinning tool to plasticize ... ORNL researchers optimized the friction-stir process to extrude the ...
... received 510(k) clearance from the U.S. Food and ... solution. This innovative software package will enable healthcare ... (linear accelerator) radiosurgery hardware and offer fast, high ... for costly hardware upgrades. HybridArc expands ...
... May 9, 2011 The Maryland Technology Enterprise Institute ... University of Maryland $75K Business Plan Competition . ... faculty teams were selected from 71 initial entries and eight ... of expert judges as well as a public audience of ...
Cached Biology Technology:Story tips from the Department of Energy's Oak Ridge National Laboratory 2Brainlab Announces FDA 510(k) Clearance for New HybridArc™ Software for Radiosurgery 2Brainlab Announces FDA 510(k) Clearance for New HybridArc™ Software for Radiosurgery 3Mtech Announces Winners of the 2011 University of Maryland $75K Business Plan Competition 2Mtech Announces Winners of the 2011 University of Maryland $75K Business Plan Competition 3Mtech Announces Winners of the 2011 University of Maryland $75K Business Plan Competition 4Mtech Announces Winners of the 2011 University of Maryland $75K Business Plan Competition 5
MOUSE ANTI HUMAN COMPLEMENT SC5B-9...
Human VEGF R Phycoerythrin Sampler (Cl 89106, 49560, 54733)...
ANTI ALPHA FSH:B...
... serum is collected from fasted mixed breed, mixed ... Available Anticoagulants: N-02: Citrate ... N-08: Potassium Oxalate N-10: ... ACD N-07: CPD N-09: ...
Biology Products: