Navigation Links
Study reveals how one form of natural vitamin E protects brain after stroke
Date:1/11/2010

ke in a way that causes neurodegeneration. We found that it can be put in check by very low levels of tocotrienol," he said. "So what we have here is a naturally derived nutrient, rather than a drug, that provides this beneficial impact."

Sen and colleagues had linked TCT's effects to various substances that are activated in the brain after a stroke before they concluded that this enzyme could serve as an important therapeutic target. The enzyme is called cystolic calcium-dependent phospholipase A2, or cPLA2.

Following the trauma of blocked blood flow associated with a stroke, an excessive amount of glutamate is released in the brain. Glutamate is a neurotransmitter that, in tiny amounts, has important roles in learning and memory. Too much of it triggers a sequence of reactions that lead to the death of brain cells, or neurons the most damaging effects of a stroke.

Sen and colleagues used cells from the hippocampus region of developing mouse brains for the study. They introduced excess glutamate to the cells to mimic the brain's environment after a stroke.

With that extra glutamate present, the cPLA2 enzyme releases a fatty acid called arachidonic acid into the brain. Under normal conditions, this fatty acid is housed within lipids that help maintain cell membrane stability.

But when it is free-roaming, arachidonic acid undergoes an enzymatic chemical reaction that makes it toxic the final step before brain cells are poisoned in this environment and start to die. Activation of the cPLA2 enzyme is required to release the damaging fatty acid in response to insult caused by high levels of glutamate.

Sen and colleagues introduced the tocotrienol vitamin E to the cells that had already been exposed to excess glutamate. The presence of the vitamin decreased the release of fatty acids by 60 percent when compared to cells exposed to glutamate alone.

Brain cells exposed to excess glutamate followed by tocot
'/>"/>

Contact: Chandan Sen
chandan.sen@osumc.edu
614-247-7786
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. What came first in the origin of life? A study contradicts the metabolism first hypothesis
2. Study examines calorie information from restaurants, packaged foods
3. Study provides insight into pathway linked to obesity
4. Sweet corn study provides large-scale picture of better fields
5. A global breakthrough in the study of a protein linked to the spread of viruses
6. Using modern sequencing techniques to study ancient modern humans
7. Short-term school closures may worsen flu pandemics, Pitt study finds
8. Researchers use new acoustic tools to study marine mammals and fish
9. Study shows a key protein helps control blood pressure
10. New study finds catch shares improve consistency, not health, of fisheries
11. Michigan State University study sheds light on microscopic flower petal ridges
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... of researchers, including scientists from the Max Planck Institute ... a major step in understanding photosynthesis, the process by ... oxygen in its atmosphere and which is therefore crucial ... , The researchers report the first direct visualization of ... step in which a specific protein complex, photosystem II, ...
(Date:7/11/2014)... Recent evidence has demonstrated that transplantation of mesenchymal stem ... rat or mouse models of Alzheimer,s disease (AD) and ... cerebral ischemia. Few studies are reported on the therapeutic ... with AD and on the effect on oxidative injury ... Yufang Yan and her team, School of Life Sciences, ...
(Date:7/11/2014)... Research and Markets has announced the addition ... Analysis Size Share Growth Trends and Forecast to 2019" ... http://photos.prnewswire.com/prnh/20130307/600769 The rising number of ... high level security in both private and public sector. ... and passwords, tokens etc. are vulnerable to attacks. Biometrics ...
Breaking Biology News(10 mins):A first direct glimpse of photosynthesis in action 2International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2
... from the University of Liverpool's School of Biological Sciences have ... Gormley's 'Another Place' art installation on Crosby Beach have become ... barnacle - Elminius modestus. , Although the barnacles have been ... from half way across the world on the coasts of ...
... threat against the viabi lity of the Scandinavian wolf ... journal PLoS ONE now demonstrates that inbreeding is not ... show that it is the most genetically variable wolf ... important consequence of this action of natural selection is ...
... device currently used for intestinal research, the colonsope, causes ... has been developed, inspired by the way in which ... her PhD degree from TU Delft based on this ... difficult area to navigate through with a medical device. ...
Cached Biology News:Living laboratory found on shoreline statues 2Wolves are suffering less from inbreeding than expected 2Like a snail through the intestinal canal 2
(Date:7/11/2014)... DUBLIN , July 11, 2014 ... in part) in, into or from any jurisdiction where to ... of such jurisdiction.  Shire plc ("Shire" or the ... Bloomberg article this afternoon.  Shire confirms it has held a ... being made by Shire without the prior agreement or approval ...
(Date:7/11/2014)... 2014 /CNW/ - Sunovion Pharmaceuticals Canada Inc. (Sunovion) today ... acetate) for use as a once-daily adjunctive therapy for ... who are not satisfactorily controlled with conventional therapy.  APTIOM ... under 18 years of age. Epilepsy ... according to Epilepsy Canada, it affects 0.6% of the ...
(Date:7/10/2014)... Product and process impurities in biopharmaceuticals ... are often “lost in the noise,” making their ... Dr. Rowel Tobias, Senior Scientist, Protein Chemistry at ... Quality at Nanotherapeutics, Inc., to lear about a ... and quantitation while achieving the required specificity and ...
(Date:7/10/2014)... CA (PRWEB) July 10, 2014 Unraveling ... closer together. The Archer Family purchased a ... within DNA, but ended up with a lifetime of ... contained within the family members’ DNA genuinely brought the ... decided to search deeper into genetic history and prior ...
Breaking Biology Technology:Shire plc - Statement re: Media Speculation 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 3Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 4Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5
... Israel and JERSEY CITY, New Jersey, December 5, Rosetta ... the,development of microRNA-based diagnostics and therapeutics, announced today,that it ... on,Thursday, December 10, from 2:30-3:35 pm EST at the ... A live audio webcast of the ...
... developing solutions based on the products of newborn fibroblasts, will be ... of the 21st Century Breakthroughs for Biomedical Research series. , ... ... a regenerative medicine company developing solutions based on the products of ...
... (Nasdaq: BCRX ) announced today that the Company ... clinical data on BCX-4208 at the 50th American Society of ... Francisco, CA from December 6-9, 2008. Forodesine HCl and ... , The schedule for BioCryst,s poster ...
Cached Biology Technology:Rosetta Genomics to Webcast Panel Presentation at RBC Capital Markets 2008 Healthcare Conference 2Rosetta Genomics to Webcast Panel Presentation at RBC Capital Markets 2008 Healthcare Conference 3Histogen Featured on Economic Report Television Series 2BioCryst to Present Three Posters During the 50th American Society of Hematology Annual Meeting and Exposition 2BioCryst to Present Three Posters During the 50th American Society of Hematology Annual Meeting and Exposition 3