Study reveals a reprogrammed role for the androge...(or itself the keyhole in the cell nuc...)
or itself the "keyhole" in the cell nucleus that androgen molecules fit into but the actual mechanism by which it operates hasn't been known.
To find that mechanism, Brown's team, including co-lead authors Qianben Wang, PhD, now of Ohio State, and Wei Li, PhD, now of Baylor College of Medicine, charted the activity levels, or expression, of genes controlled by the androgen receptor in androgen-dependent and androgen-independent prostate cancer cells. In the androgen-independent cells, they found a group of genes with epigenetic markings tiny attachments to DNA that switchs genes on and off that caused them to be especially active. The genes form a completely separate pathway from the one active in androgen-dependent cells.
It's not known what causes those epigenetic changes to occur, but "we are profiling the genome-wide epigenetic landscape of androgen-dependent and -independent cancers, trying both experimental and computational methods to identify additional regulators," says study co-senior author X. Shirley Liu, PhD, of Dana-Farber.
"The androgen receptor clearly works by an entirely different program in androgen-dependent and -independent cancers," says Wang. "Having discovered that program, we'll be in a better position to understand how it operates and how gene-targeted therapies may shut it down."
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| Contact: Anne Doerr anne_doerr@dfci.harvard.edu 617-632-5665 Dana-Farber Cancer Institute Source:Eurekalert |
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