Navigation Links
Study reveals a key to blood vessel growth and possible drug target
Date:10/14/2007

team determined that two well known signaling molecules, birc2 and TNF, are crucial to the survival of endothelial cells -- which line the blood vessels and maintain the integrity of the blood vessel wall during vascular development -- in zebrafish embryos.

The pathway these molecules make up during vascular development has not been looked at before, says Stainier. It offers a new target for therapeutic strategies.

The birc2 gene belongs to a family of proteins that control the balance between cell survival and cell death (apoptosis). A cell induces apoptosis when it detects that it is irreparably damaged. The integrity of the blood vessel wall is determined by a dynamic balance between endothelial cell survival and apoptosis.

The scientists started the investigation by examining zebrafish with unusual physical characteristics and working to identify the mutated genes that were responsible for the traits.

We began with a genetic mutant that displayed vascular hemorrhage associated with vascular defects, and soon proved that the mutant had a defective birc2 gene, says Santoro. Without the birc2 gene, hemorrhage and blood pooling occurred, resulting in vascular regression and cell death.

Next, through a series of genomic analyses and biochemical studies, the team discovered the critical role of birc2 and TNF in blood vessel health in the zebrafish embryo. They showed that birc2 is needed for the formation of the tumor necrosis factor receptor complex 1, a group of proteins and peptides that activate cell survival by initiating signals. Tumor necrosis factor promotes activation of NF-kB, a protein complex transcription factor involved in the transfer of genetic information. Further tests proved the existence of a genetic link between the birc2/NF-kB pathway, and that it is critical for vascular health and endothelial cell survival.

Studies on vascular development are important so that we can better understand
'/>"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Bioartificial kidney under study at MCG
2. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
3. W.M. Keck Foundation funds study of friendly microbes
4. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
5. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
6. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
7. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
8. Study Links Ebola Outbreaks To Animal Carcasses
9. Genome-wide mouse study yields link to human leukemia
10. Breakthrough Microarray-based Technology for the Study of Cancer
11. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... Society (ACS) announced today that Courtney Aldrich, Ph.D., ... Infectious Diseases as editor-in-chief. With the first ... pioneering journal will meet a growing demand for ... research. , "Our vision is to develop a ... on the basic science that advances the field ...
(Date:7/10/2014)... HOUSTON (July 10, 2014) New research from ... (UTHealth) shows that It,s Your GameKeep it Real (IYG), ... and promote healthy dating relationships, can significantly reduce dating ... Centers for Disease Control and Prevention, 10 percent of ... and other studies suggest that more than 20 percent ...
(Date:7/10/2014)... 10,2014 For children and teens living with a ... contribute to decreased quality of life, reports a study ... Behavioral Pediatrics , the official journal of the ... The journal is published by Lippincott Williams & ... . , "Self-competence may function as a protective factor ...
Breaking Biology News(10 mins):ACS Infectious Diseases: Unique chemistry journal names editor 2It's Your Game ... Keep It Real reduces dating violence among minority youth 2For children with pacemakers, 'self-competence' affects quality of life 2
... HOUSTON, Aug. 13, 2007 It,s not a good idea to ... moth. Found in the parched Sonoran desert of southern Arizona ... species -- the senita cactus -- both for its food and ... dependent upon the moth, the only species that pollinates its flowers. ...
... 13, 2007) In some ways, certain tumors resemble bee colonies, ... plays a specific role, and just a fraction of the ... themselves in an unspecialized state and seed new tumors. These ... form the bulk of the tumor. These queens ...
... - Do bats use their ultrasonic echolocation calls to ... Journal of Biogeography by Danilo Russo and colleagues suggests ... (Rhinolophidae). These bats find their way in the dark ... mainly made of a constant frequency. Different rhinolophid species ...
Cached Biology News:Which came first, the moth or the cactus? 2Which came first, the moth or the cactus? 3Newly created cancer stem cells could aid breast cancer research 2Newly created cancer stem cells could aid breast cancer research 3A 'private bandwidth' for communication in bats: Evidence from insular horseshoe bats 2
(Date:7/10/2014)... UK (PRWEB) July 10, 2014 ... 21st Century Medicine Forum on ‘Commercialising Longevity Research’ ... and entrepreneurs to the London Bioscience Innovation Center ... Research Foundation and Aging Analytics Ltd. The meeting ... investment in translational research for age-related disease, as ...
(Date:7/10/2014)... Francisco, CA (PRWEB) July 10, 2014 ... family closer together. The Archer Family purchased a ... contained within DNA, but ended up with a lifetime ... discoveries contained within the family members’ DNA genuinely brought ... had decided to search deeper into genetic history and ...
(Date:7/10/2014)... EvoDerma ’s NOOME Anti-Aging Motion has been upgraded ... with a second treatment cup to help prevent and smooth ... is thinner on the edges for a softer contact with ... uneven surfaces on the face, neck and décolleté. Choose to ... areas such as the cheeks and neck, or opt for ...
(Date:7/10/2014)... 10, 2014 On July 9 ... , presented Russia,s first national ... The Company is developing a unique project called ... develops a number of innovative drugs based on monoclonal ... ceremony took place at the International Exhibition "Innoprom 2014" ...
Breaking Biology Technology:DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2
... it will release its fiscal 2008 second quarter,results for the period ... closes. Senior management will host a live webcast and,conference call to ... What: Plexus Corp.,s Fiscal ... Thursday, April 24th at 8:30 a.m. Eastern Time, Where: ...
... Md., April 24 United,Therapeutics Corporation (Nasdaq: ... 2008 first quarter financial results before the open ... Therapeutics will host a half-hour teleconference on Thursday,May ... teleconference is accessible by,dialing 1-800-603-1777, with international callers ...
... - SimBioSys, a leader in the field of,rational ... parallel,computer architecture to dramatically speed up the process ... the speed by which,scientists can perform virtual screening ... eHiTS software on the,IBM(R) BladeCenter(R) QS2 based on ...
Cached Biology Technology:Plexus Q2 Earnings Release on April 23rd After Market Close and Conference Call on April 24th at 8:30 am E.T. 2SimBioSys Utilizes Revolutionary Hardware Technology to Open New Frontiers in Molecular Modeling 2
... GC-rich nucleic acids ,The GC-RICH PCR ... and a proofreading polymerase, powers through templates ... with other polymerases and other blends of ... and the unique GC-RICH Resolution Solution combine ...
... Hot Start Taq ... activity before the onset ... nonspecific amplification and primer-dimer ... is raised, the antibody ...
B-FABP (FL-132)...
Roll of Mesh 5m x 25cm...
Biology Products: