Navigation Links
Study resolves debate on human cell shut-down process
Date:4/12/2012

Researchers at the University of Liverpool have resolved the debate over the mechanisms involved in the shut-down process during cell division in the body.

Research findings, published in the journal PNAS, may contribute to future studies on how scientists could manipulate this shut-down process to ensure that viruses and other pathogens do not enter the cells of the body and cause harm.

Previous research has shown that when cells divide, they cannot perform any other task apart from this one. They cannot, for example, take in food and fluids at the same time as managing the important process of dividing into 'daughter cells' to replicate the body's genetic information. Cells, instead, shut-down the intake of food and fluid during cell division and for many years it was thought that they did this by preventing a vehicle - called a receptor - from transporting nutrients through the cell membrane.

In recent years scientists have shown evidence to suggest that this theory may be wrong. Scientists have argued that the cell does not shut down the mechanisms that allow food and fluid to enter the cell as previously thought, but rather the receptors that transport this fuel are absent altogether during cell division, allowing the cell to focus on the one task of dividing.

Studies at Liverpool, however, have now shown that the original theory, first documented in 1965, is accurate. The receptors are present and able to transport food and fluid during cell division, but the mechanism that allows them through the membrane of the cell shuts-down until cell division is complete.

Dr Stephen Royle, from the University's Institute of Translational Medicine, explains: "We know that cells in the body do not have the ability to multi-task during cell division. It can only focus on the job of dividing and not on other important tasks such as uptake of nutrients. If we think of the cell membrane like a dock at a port and the receptors as a boat delivering cargo, we have shown that the boat, or receptor, is present but the dock, or membrane, does not allow it to unload or go any further.

"Viruses and pathogens use the same route into cells as nutrients, so the next stage of this work is to identify the trigger for this shut-down process, so that we understand whether this on/off switch can be manipulated to prevent harmful infections passing through the cell membrane. This is a long way in the future, but this work puts us closer to understanding how the cells in the body work."


'/>"/>
Contact: Samantha Martin
samantha.martin@liv.ac.uk
44-015-179-42248
University of Liverpool
Source:Eurekalert

Related biology news :

1. Study shows botanical formula fights prostate cancer
2. Approach to diabetes self-management too narrow, study suggests
3. Study finds peoples niceness may reside in their genes
4. Loyola study debunks common myth that urine is sterile
5. UCSB study shows forest insects and diseases arrive in US via imported plants
6. Head and body lice appear to be the same species, genetic study finds
7. Life expectancy may affect when you get married, divorced, have kids: Queens University study
8. Sexual reproduction brings long-term benefits, study shows
9. Researchers use game to change how scientists study disease outbreaks
10. Copper chains: Study reveals Earths deep-seated hold on copper
11. Study shows unified process of evolution in bacteria and sexual eukaryotes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/13/2017)... Jan. 13, 2017 Sandata Technologies, LLC, ... the homecare industry, including Electronic Visit Verification™ (EVV™), ... Justin Jugs, as Senior Vice President of Product ... years of homecare experience to Sandata, where he ... plans to align Sandata,s suite of solutions with ...
(Date:1/11/2017)... Jan. 11, 2017 Intoxalock, a leading ignition ... release of its patent-pending calibration device. With this new ... calibrations, securely upload data logs and process repairs at ... "Fighting drunk driving through the application of ... at large, but also for the customer who can ...
(Date:1/6/2017)... 5, 2017  Delta ID Inc., a leader in ... for automotive at CES® 2017. Delta ID has collaborated ... demonstrate the use of iris scanning as a secure, ... driver in a car, and as a way to ... Delta ID and Gentex will demonstrate (booth ...
Breaking Biology News(10 mins):
(Date:1/21/2017)... Jan. 20, 2017 Interpace Diagnostics Group, ... that provides clinically useful molecular diagnostic tests and ... into a securities purchase agreement with three  institutional ... of common stock in a registered direct offering.  ... agreed to sell to the same investors warrants ...
(Date:1/20/2017)... ... ... The two newest companies to join the University City Science Center’s Port business ... Wistar Institute, and Sanguis, launched by a trio of students from the University of ... developing a treatment for a chronic viral infection and its associated diseases, with the ...
(Date:1/20/2017)... MA (PRWEB) , ... January ... ... leader in Less Exposure Surgery (LES®) Technologies, announced today the next evolution ... PedFuse Pedicle Screw System platform). In contrast to the competition, SpineFrontier is ...
(Date:1/19/2017)... 19, 2017 /PRNewswire -- WuXi AppTec, a leading ... and technology platform, today announced that it has ... preclinical drug discovery contract research organization (CRO). After ... wholly-owned subsidiary of WuXi, and will continue to ... greater services. The acquisition will further strengthen WuXi,s ...
Breaking Biology Technology: