Navigation Links
Study reports iron oxide nanoparticles effective for labeling human endothelial cells
Date:12/20/2012

Putnam Valley, NY. (Dec. 20, 2012) A team of researchers from three medical institutions in Guangzhou, China, have found that iron oxide nanoparticles (INOPS) are a useful contrast agent for in vivo magnetic resonance tracking of transplanted human endothelial cells. However, the impact of INOPS on the cells varies with a number of factors including the INOPS load. They found that the percentage of iron-labeled cells was significantly lower after 48 hours post-transplantation than at 24 hours post-transplantation. They also found that high INOPS concentration can affect cell activity. High INOPS concentration can induce cell death (apoptosis).

Their study is published in the current issue of Cell Transplantation (21:9), now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/.

"A good MRI contrast agent must possess a number of features," said study co-author Dr. Wen-Li Chen, at South China Normal University's MOE Key Laboratory of Laser Life Science. "Those features are: low toxicity and good stabilization, high sensitivity, good solubility and the ability to remain in the target cell for a long time. In our study, we found that INOPS are sensitive and can perturb the static magnetic field and provide a string change in MR signals."

The researchers found that the INOPS could be taken up by the cell rather than adhering to the exterior of the cell membrane. However, they also found that a proportional relationship might exist between the number of labeled cells and signal intensity.

"For the first time, we identified that autophagy death could take place at high INOPS loading concentrations," said the researchers.

They also discovered that an increased incubation time, from 24 to 48 hours, did not increase cellular uptake of INOPS and that the percentage of labeled cells declined after 24 hours to be significantly lower by 48 hours.

"It is possible that when the intracellular iron becomes saturated, the particles may start to be expelled out of cells," they concluded. "Thus, the determination of optimal loading concentration is an important step in maintaining the quality of cell labeling and cell activity."


'/>"/>

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. Study looks at gray seal impact on beach water quality
2. Study reveals that animals contribute to seagrass dispersal
3. UC Irvine study of leaping toads reveals muscle-protecting mechanism
4. NTU study finds ways to prevent muscle loss, obesity and diabetes
5. Hass Avocado Board study published in Food & Function journal
6. Univ. of MD School of Medicine to study drug-resistant malaria in Myanmar
7. Study offers insights into role of muscle weakness in Down syndrome
8. University of Tennessee study predicts extreme climate in Eastern US
9. New menhaden study will help identify balance between fishing and preserving Bay forage fish
10. Study uncovers mechanism used by BRCA1 to suppress tumors
11. Penn Study shows resistance to cocaine addiction may be passed down from father to son
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2016)... 2016 "Increase in mobile transactions is driving ... biometrics market is expected to grow from USD 4.03 ... at a CAGR of 29.3% between 2016 and 2022. ... growing demand for smart devices, government initiatives, and increasing ... component is expected to grow at a high rate ...
(Date:12/8/2016)... , Dec. 8, 2016 Market Research Future published ... Market. The global Mobile Biometric Security and Service Market is expected ... to 2022. Market Highlights: ... , , Mobile Biometric ... due to the increasing need of authentication and security from unwanted ...
(Date:12/7/2016)... to a new market research report "Emotion Detection and Recognition Market by Technology ... End User, And Region - Global Forecast to 2021", published by MarketsandMarkets, the ... USD 36.07 Billion by 2021, at a Compound Annual Growth Rate (CAGR) of ... ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:1/21/2017)... Colo. , Jan. 20, 2017 ... or the "Company"), announced that on January 14, 2017 ... plan under which the Company will terminate certain employees ... Bioptix Diagnostics, Inc.  The Company commenced terminations on January ... within 30 days.  The Company may pay severance benefits ...
(Date:1/20/2017)... , Jan. 20, 2017 Ginkgo ... of Gen9, a pioneer in the synthesis and ... unique expertise in assembling pathway-length synthetic DNA into ... and capacity in the construction of new organism ... industries. "Gen9 was founded to significantly ...
(Date:1/19/2017)... HOUSTON , Jan. 19, 2017 ... announced the formation of its Medical/Clinical Advisory Board. ... industry veterans who enhance the range and depth ... development of its novel prenatal diagnostic tests.  These ... and strategic guidance for the company,s product development ...
(Date:1/19/2017)... GAITHERSBURG, Md. , Jan. 19, 2017 ... Inc., a privately-held immunotherapeutics company targeting infectious diseases, ... for the merger of PharmAthene and Altimmune in ... Venture Fund, HealthCap, Truffle Capital and Redmont Capital. ... diversified immunotherapeutics company with four clinical stage and ...
Breaking Biology Technology: