Navigation Links
Study puts a new spin on ibuprofen's actions
Date:9/25/2011

Ibuprofen, naproxen, and related non-steroidal anti-inflammatory drugs (NSAIDs) the subjects of years of study still have some secrets to reveal about how they work.

Vanderbilt University investigators have discovered surprising new insights into the actions of NSAIDs. Their findings, reported Sept. 25 in Nature Chemical Biology, raise the possibility of developing a new class of inflammation- and pain-fighting medicines.

NSAIDs block the activity of the cyclooxygenase enzymes, COX-1 and COX-2.

"Until about three years ago, we thought we knew everything there was to know about these enzymes and these inhibitors, but we were unaware of some of the details of how they work," said Lawrence Marnett, Ph.D., director of the Vanderbilt Institute of Chemical Biology and professor of Biochemistry, Chemistry and Pharmacology.

COX-1 and COX-2 oxygenate (add oxygen to) the lipid arachidonic acid to generate biologically active prostaglandins. Marnett and his team discovered about 10 years ago that COX-2 (but not COX-1) also oxygenates endocannabinoids naturally occurring analgesic and anti-inflammatory agents that activate cannabinoid receptors (the same receptors that marijuana activates).

The investigators then made a puzzling observation. They found that ibuprofen was a more potent inhibitor of endocannabinoid metabolism compared to arachidonic acid metabolism.

"This was the same drug inhibiting two substrates of the same protein differently," Marnett said. "We didn't understand it."

In the current report, the researchers surveyed a series of different types of NSAIDs for inhibition of COX-2. They included the "mirror-image" versions of ibuprofen, naproxen and flurbiprofen (these drugs come in two different chemical configurations a "right hand" (R) version and a "left hand" (S) version over-the-counter ibuprofen is a mixture of both forms). It had previously been assumed that only the S-forms of these NSAIDs (S-profens) were able to
'/>"/>

Contact: Leigh MacMillan
leigh.macmillan@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert  

Page: 1 2

Related biology news :

1. University of Arizona to study human-fire-climate interactions
2. Aquarium fishes are more aggressive in reduced environments, a new study finds
3. Harvard School of Public Health awarded $20 million CDC grant to study HIV prevention in Botswana
4. Twin study reveals epigenetic alterations of psychiatric disorders
5. Causes of Gulf War Illness are complex and vary by deployment area -- Baylor University study
6. Study finds bidirectional relationship between schizophrenia and epilepsy
7. CONRAD presents results of pivotal contraceptive study at Reproductive Health 2011
8. Study in underwater laboratory may help manage seaweed-eating fish that protect coral
9. Study finds an increase of children accidentally poisoned with pharmaceuticals
10. UF-led study: Invasive amphibians, reptiles in Florida outnumber world
11. Voting causes stress according to Ben-Gurion University of the Negev study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study puts a new spin on ibuprofen's actions
(Date:10/30/2014)... This news release is available in German . ... we as individuals prompt our fellow humans to behave ... to social dilemmas in game theory. Previous studies assumed ... large groups. Nonetheless, scientists from the Max Planck Institute ... us can exert an influence on the cooperative behaviour ...
(Date:10/30/2014)... 29, 2014  Securus Technologies, a leading ... solutions for public safety, investigation, corrections and ... exciting enhancements to its THREADS™ product, which ... actionable intelligence and focused leads for investigators. ... technological innovation through identifying and delivering solutions ...
(Date:10/29/2014)... Online registration is open for the ... Scientific Meeting. SIR 2015 is the one ... trainees and related health care professionals can ... image-guided science and technologies being presented, discussed ... community in minimally invasive, image-guided medicine, SIR ...
Breaking Biology News(10 mins):Together we are strong -- or insufferable 2Together we are strong -- or insufferable 3Together we are strong -- or insufferable 4Securus Technologies Adds Advanced Features to Its Industry-Leading Investigative Analytics Product 2SIR 2015: Interventional radiology shapes tomorrow's medicine 2
... tools of physics to show how our circadian clocks ... environment. , In an article appearing March 13 ... Ecole Polytechnique Federale de Lausanne demonstrate that the stability ... recent association studies in families affected by advanced sleep ...
... molecule and snake venom may provide researchers with a ... new drugs. , Purdue University researchers bound a complex ... that was delivered to specific proteins in living venom ... a better way to ascertain the presence, concentration and ...
... A new statistical method of determining genetic traits that ... productive livestock. , Scientists from Purdue University, the ... to choose animals that are more congenial in groups, ... geneticist. The new method is a tool that may ...
Cached Biology News:Keeping the body in sync -- The stability of cellular clocks 2Scientists use nanoparticle to discover disease-causing proteins 2Scientists find method to pick noncompetitive animals, improve production 2
(Date:10/27/2014)... 2014 New Q4-2014 incentives help ... an industry leading unified communication and collaboration provider, ... to deliver cloud-based audio and web/video conferencing solutions ... With SoundConnect’s Q4 incentive partners will ... web conferencing licenses sold, now through December 31st, ...
(Date:10/27/2014)... HORSHAM, Pa. , Oct. 27, 2014 /PRNewswire/ ... Colitis Foundation of America (CCFA) announced today the ... , an educational campaign designed ... bowel diseases (IBD) on the paired role of ... To view the multimedia assets associated with ...
(Date:10/25/2014)... The report “Adipic Acid Market by Application, by ... & Forecast to 2019” report analyzes the adipic ... and trends in different regions. , Browse 119 ... 217 slides and in-depth TOC on “Adipic Acid ... http://www.marketsandmarkets.com/Market-Reports/adipic-acid-269.html , Early buyers will receive 10% ...
(Date:10/25/2014)... 24, 2014 DuPont Pioneer and ... more than double the acreage contracted for Plenish® ... its soybean crush facility in Salisbury, Md. The ... will target several markets including foodservice and food ... performance. , For the 2015 growing season, Perdue ...
Breaking Biology Technology:SoundConnect Unveils Q4 Partner Incentives 2Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 2Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 3Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 4Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 2Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 3Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 4DuPont Pioneer, Perdue AgriBusiness Announce Plans to Double Acreage for the 2015 Plenish® High Oleic Soybean Program 2DuPont Pioneer, Perdue AgriBusiness Announce Plans to Double Acreage for the 2015 Plenish® High Oleic Soybean Program 3DuPont Pioneer, Perdue AgriBusiness Announce Plans to Double Acreage for the 2015 Plenish® High Oleic Soybean Program 4
... signing to follow his presentation, WASHINGTON, Sept. ... global marketplace, and the role of,financing are focus ... presentations will focus on the convergence of the,MedTech ... patient monitoring,technologies, critical issues to consider when entering ...
... Detecting deadly fumes in subways, toxic gases in ... becoming easier and more efficient with a measurement ... the technique,s sensitivity, scientists must design better scattering ... , Researchers at the University of Illinois, led ...
... in secret. , Most people did not know that ... Sandia National Laboratories was contributing important information to the ... that cause the disease anthrax. The spores were mailed ... offices and to two U.S. senators. Five people were ...
Cached Biology Technology:Former Speaker of the House Newt Gingrich Featured Wednesday 2Killer pulses help characterize special surfaces 2FBI unveils science of anthrax investigation 2FBI unveils science of anthrax investigation 3
Rabbit polyclonal to Glutathione S Transferase alpha ( Abpromise for all tested applications). Antigen: Full length protein: Human Glutathione S Transferase alpha. Entrez GeneID: 2938 Swi...
Anti-Mouse IgM Heavy Chain:FITC, Clone LO-MM-9, Monoclonal Antibody...
Rabbit polyclonal to FOXJ2 ( Abpromise for all tested applications). entrezGeneID: 55810 SwissProtID: Q9P0K8...
Goat polyclonal to HSPC150 ( Abpromise for all tested applications). entrezGeneID: 29089...
Biology Products: