Navigation Links
Study provides treatment hope for long term effects of brain trauma
Date:11/2/2010

Brain damage continues to develop and evolve for months after a traumatic brain injury (TBI), revealing a potential target for treatments to improve brain trauma, new research led by the University of Melbourne, Australia has found.

The study funded by the Victorian Neurotrauma Initiative is published in the latest issue of The Journal of Nuclear Medicine (JNM).

Around 400,000 Australians have a disability related to traumatic brain injury with cognitive, psychiatric and epileptic problems the most common symptoms. The major cause of TBI is motor vehicle accidents. Other causes include falls, sports injuries and violent crime.

Professor Terry O'Brien, Head of the University of Melbourne's Department of Medicine at the Royal Melbourne Hospital and a senior author on the paper said the results provided new insights into the progressive nature of how the brain changes following injury.

"Patients who suffer brain injury commonly experience long-term neurological and psychiatric problems, including memory and thinking difficulties, anxiety and depression, and epilepsy. Currently there are no effective interventions to reduce the incidence or severity of these problems," Professor O'Brien said.

"We have demonstrated that changes in brain structure and function after traumatic brain injury are dynamic and continue to progress and evolve for many months. This opens up a window of opportunity to give treatments to halt this damage, and therefore reduce the long term neurological and psychiatric complications that many patients experience," he said.

Using powerful imaging techniques--positron emission tomography (PET) fused with magnetic resonance imaging (MRI)-- on animal models researchers have been able to better understand the long-term functional and structural changes that take place after traumatic brain injury.

The study revealed widespread decreases in brain functioning in specific regions of the brain, many of which are remote from the site of the direct trauma and showed no signs of initial injury on the MRI. The hippocampus, a brain structure critical to memory and emotion, is the key area of these changes.

This study has also provided a platform for testing the biological effectiveness of potential new therapies before embarking on expensive and lengthy clinical trials.

"Our discovery could also be applicable to the study of other neurological diseases, such as stroke, dementia, multiple sclerosis brain infections and epilepsy, which are associated with long-term progressive degenerative changes in the brain," Professor O'Brien said.

Traumatic brain injury is a leading cause of death and disability in children and young adults around the world. Long-term disabilities following TBI include: cognitive disabilities such as disorders in attention, memory, learning and executive functioning; psychiatric and behavioral problems including depression, anxiety, aggression, agitation and social inappropriateness; and epilepsy.


'/>"/>

Contact: Rebecca Scott
rebeccas@unimelb.edu.au
61-383-440-181
University of Melbourne
Source:Eurekalert

Related biology news :

1. Long-term study shows effect of climate change on animal diversity
2. £2 million study to reveal workings of dementia genes
3. New study looks to define evangelicals and how they affect polling
4. CU-Boulder study suggests air quality regulations miss key pollutants
5. Researchers study acoustic communication in deep-sea fish
6. Study reveals homeowner perceptions in fire-prone areas
7. Researchers study how pistachios may improve heart health
8. Study: urban black bears live fast, die young
9. New study indicates link between weight gains during pregnancy and dieting history
10. Study reveals specific gene in adolescent men with delinquent peers
11. Sweat it out: UH study examines ability of sweat patches to monitor bone loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2016)... LONDON , April 26, 2016 ... a product subsidiary of Infosys (NYSE: ... to integrate the Onegini mobile security platform with ... http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The integration will ... to access and transact across channels. Using this ...
(Date:4/15/2016)... April 15, 2016 Research ... Gait Biometrics Market 2016-2020,"  report to their offering.  ... ) , ,The global gait biometrics market is ... during the period 2016-2020. Gait analysis ... can be used to compute factors that are ...
(Date:3/31/2016)... , March 31, 2016  Genomics firm Nabsys ... founding CEO, Barrett Bready , M.D., who returned ... of the original technical leadership team, including Chief Technology ... of Product Development, Steve Nurnberg and Vice President of ... to the company. Dr. Bready served as ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Newly ... technologies, services and solutions to the healthcare market. The company's primary focus is ... manufacturing, sales and marketing strategies that are necessary to help companies efficiently bring ...
(Date:6/24/2016)... DIEGO , June 24, 2016 ... more sensitively detects cancers susceptible to PARP inhibitors ... circulating tumor cells (CTCs). The new test has ... HRD-targeted therapeutics in multiple cancer types. ... targeting DNA damage response pathways, including PARP, ATM, ...
(Date:6/23/2016)... , June 23, 2016   Boston ... of novel compounds designed to target cancer stemness ... has been granted Orphan Drug Designation from the ... treatment of gastric cancer, including gastroesophageal junction (GEJ) ... inhibitor designed to inhibit cancer stemness pathways by ...
(Date:6/23/2016)...  The Prostate Cancer Foundation (PCF) is pleased to announce 24 ... for prostate cancer. Members of the Class of 2016 were selected from a ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
Breaking Biology Technology: