Navigation Links
Study provides treatment hope for long term effects of brain trauma
Date:11/2/2010

Brain damage continues to develop and evolve for months after a traumatic brain injury (TBI), revealing a potential target for treatments to improve brain trauma, new research led by the University of Melbourne, Australia has found.

The study funded by the Victorian Neurotrauma Initiative is published in the latest issue of The Journal of Nuclear Medicine (JNM).

Around 400,000 Australians have a disability related to traumatic brain injury with cognitive, psychiatric and epileptic problems the most common symptoms. The major cause of TBI is motor vehicle accidents. Other causes include falls, sports injuries and violent crime.

Professor Terry O'Brien, Head of the University of Melbourne's Department of Medicine at the Royal Melbourne Hospital and a senior author on the paper said the results provided new insights into the progressive nature of how the brain changes following injury.

"Patients who suffer brain injury commonly experience long-term neurological and psychiatric problems, including memory and thinking difficulties, anxiety and depression, and epilepsy. Currently there are no effective interventions to reduce the incidence or severity of these problems," Professor O'Brien said.

"We have demonstrated that changes in brain structure and function after traumatic brain injury are dynamic and continue to progress and evolve for many months. This opens up a window of opportunity to give treatments to halt this damage, and therefore reduce the long term neurological and psychiatric complications that many patients experience," he said.

Using powerful imaging techniques--positron emission tomography (PET) fused with magnetic resonance imaging (MRI)-- on animal models researchers have been able to better understand the long-term functional and structural changes that take place after traumatic brain injury.

The study revealed widespread decreases in brain functioning in specific regions of the brain, many of which are remote from the site of the direct trauma and showed no signs of initial injury on the MRI. The hippocampus, a brain structure critical to memory and emotion, is the key area of these changes.

This study has also provided a platform for testing the biological effectiveness of potential new therapies before embarking on expensive and lengthy clinical trials.

"Our discovery could also be applicable to the study of other neurological diseases, such as stroke, dementia, multiple sclerosis brain infections and epilepsy, which are associated with long-term progressive degenerative changes in the brain," Professor O'Brien said.

Traumatic brain injury is a leading cause of death and disability in children and young adults around the world. Long-term disabilities following TBI include: cognitive disabilities such as disorders in attention, memory, learning and executive functioning; psychiatric and behavioral problems including depression, anxiety, aggression, agitation and social inappropriateness; and epilepsy.


'/>"/>

Contact: Rebecca Scott
rebeccas@unimelb.edu.au
61-383-440-181
University of Melbourne
Source:Eurekalert

Related biology news :

1. Long-term study shows effect of climate change on animal diversity
2. £2 million study to reveal workings of dementia genes
3. New study looks to define evangelicals and how they affect polling
4. CU-Boulder study suggests air quality regulations miss key pollutants
5. Researchers study acoustic communication in deep-sea fish
6. Study reveals homeowner perceptions in fire-prone areas
7. Researchers study how pistachios may improve heart health
8. Study: urban black bears live fast, die young
9. New study indicates link between weight gains during pregnancy and dieting history
10. Study reveals specific gene in adolescent men with delinquent peers
11. Sweat it out: UH study examines ability of sweat patches to monitor bone loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... DUBLIN , Feb. 5, 2016 /PRNewswire/ ... the addition of the "Global Facial ... offering. --> http://www.researchandmarkets.com/research/5kvw8m/global_facial ) has ... Facial Recognition Market 2016-2020" report to ... Markets ( http://www.researchandmarkets.com/research/5kvw8m/global_facial ) has announced the ...
(Date:2/3/2016)... , Feb. 3, 2016 Vigilant Solutions ... Police Department in Missouri solved ... plate reader (LPR) data from Vigilant Solutions. ... case in which the victim was walking out of a convenience store and ... space next to his vehicle, striking his vehicle and ...
(Date:2/2/2016)... , Feb. 2, 2016 Checkpoint ... that Rising Market Are you interested in ... forecasts revenues for checkpoint inhibitors. Visiongain,s report gives ... submarket, product and national level. Avoid falling ... what progress, opportunities and revenues those emerging cancer ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... 2016  Spectra BioPharma Selling Solutions (Spectra) is ... biopharma companies the experience, expertise, operational delivery and ... sales teams. Created in concert with industry leading ... strategic and tactical needs of its clients by ... both personal and non-personal promotion. ...
(Date:2/11/2016)... DELRAY BEACH, Florida , February 11, 2016 ... --> PositiveID Corporation ("PositiveID" or "Company") (OTCQB: ... and diagnostics, announced today that its Thermomedics subsidiary, ... significant progress on its growth plan in January ... healthcare products distributors, increasing sequential monthly sales growth, ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... stem cell treatment clinic in Quito, Ecuador. The new facility will provide advanced ... to patients from around the world. , The new GSCG clinic is ...
(Date:2/10/2016)... Feb. 10, 2016 NX Prenatal Inc., a ... NeXosome® technology for early warning of adverse pregnancy ... recent study by Dr. Thomas McElrath ... Maternal Fetal Medicine,s (SMFM) annual meeting held in ... , 2016.  The presentation reported initial positive top-line ...
Breaking Biology Technology: