Navigation Links
Study provides new insights into structure of heart muscle fibers
Date:5/28/2012

A study led by researchers from McGill University provides new insights into the structure of muscle tissue in the heart a finding that promises to contribute to the study of heart diseases and to the engineering of artificial heart tissue.

The research, published in the Proceedings of the National Academy of Sciences (PNAS), reveals that the muscle fibers in the heart wall are locally arranged in a special "minimal surface," the generalized helicoid. The results add a significant new dimension to our understanding of the structure and function of heart-wall muscle fiber since minimal surfaces arise in nature as optimal solutions to physical problems. (A more familiar example of a minimal surface is the film that forms when a wireframe is dipped in a solution of soap.)

Surgeons and anatomists have been examining the geometry of muscle fibers in the heart for decades, and have long known that muscle cells are aligned to form helices that wind around the ventricles. But these analyses have been confined largely to the level of individual fibers. Partly because of the limitations of traditional histology techniques, little work has been done on the more-complex geometry of groups of fibers.

Working with collaborators at Eindhoven University of Technology in the Netherlands, and Yale University in the U.S., the McGill-led team used a combination of Diffusion Magnetic Resonance Imaging (dMRI) and computer modeling to reveal the way that bundles of fibers bend together. The researchers examined images of the heart tissue of rats, humans and dogs and found the same pattern.

"You can think of it as analyzing a clump of hair instead of an individual hair strand," explains Professor Kaleem Siddiqi of McGill's School of Computer Science. "We've discovered that the clump bends and twists in the form of a particular minimal surface, the generalized helicoid and this is true across species. It's not particular to just one mammal. The implications of these findings are broad."

The knowledge could be used, for example, to provide a scaffold to guide the repair of heart-wall damage caused by heart attacks. While regeneration of muscle tissue is a major area in bioengineering, most developments in this field have involved skeletal muscle tissue such as that in arms and legs which is arranged in a different, more linear structure.

The first author of the study is Dr. Peter Savadjiev of Harvard Medical School, whose research on this problem began while he was a doctoral student of Prof. Siddiqi's at McGill. Other co-authors of the paper are Gustav J. Strijkers and Adrianus J. Bakermans of Eindhoven University, Emmanuel Piuze of McGill, and Steven W. Zucker of Yale University.


'/>"/>

Contact: Chris Chipello
christopher.chipello@mcgill.ca
514-398-4201
McGill University
Source:Eurekalert

Related biology news :

1. U of M study finds titan cells protect Cryptococcus
2. Variations of a single gene can lead to too much or too little growth, study shows
3. Yale study concludes public apathy over climate change unrelated to science literacy
4. T cells hunt parasites like animal predators seek prey, a Penn Vet-Penn Physics study reveals
5. Study finds voter genetics may predict election outcomes
6. Army study: DNA vaccine and duck eggs protect against hantavirus disease
7. New HealthFocus® International Study Reveals Five Very Different Weight Management Consumers
8. New study shows how nanotechnology can help detect disease earlier
9. University of Leicester study finds low agreeableness linked to a preference for aggressive dogs
10. Squid ink from Jurassic period identical to modern squid ink, U.Va. study shows
11. Richer parasite diversity leads to healthier frogs, says University of Colorado study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/3/2017)... , Feb. 3, 2017 A new ... Identity Strategy Partners, LLP (IdSP) . Designed to fill ... the complex identity market, founding partners Mark Crego ... 35 combined years just in identity expertise that span ... and non-profit leadership. The Crego-Kephart combined expertise has a ...
(Date:2/2/2017)... YORK , Feb. 2, 2017  EyeLock LLC, ... released a new white paper " What You Should ... The problem of ensuring user authenticity is a growing ... the authentication of users. However, traditional authentication schemes such ... Biometric authentication offers an elegant solution ...
(Date:2/1/2017)... 1, 2017 IDTechEx Research, a leading provider ... announces the availability of a new report, Sensors for Robotics: ... Continue Reading ... ... robots. Source: IDTechEx Report "Sensors for Robotics: Technologies, Markets and Forecasts ...
Breaking Biology News(10 mins):
(Date:2/27/2017)... -- Four US Biotech equities have been ... are: Anthera Pharmaceuticals Inc. (NASDAQ: ANTH), Arrowhead Pharmaceuticals Inc. ... and Conatus Pharmaceuticals Inc. (NASDAQ: CNAT ). ... are growing more bullish on the sector as a ... cash held overseas for tax reason by large US ...
(Date:2/27/2017)... ... ... The Catalyst Midwest premix manufacturing facility has been certified as organic, ... label organic services. , The first organic product is Organic 18 Percent Layer Feed, ... Marketing, which owns the facility. , Catalyst already has received the Safe Feed/Safe ...
(Date:2/24/2017)... SAN FRANCISCO, CA (PRWEB) , ... February 24, 2017 , ... ... awarding of a $224K grant from the National Institute of Mental Health (NIMH) for ... is based on Delpor’s PROZOR technology and is expected to deliver therapeutic ...
(Date:2/24/2017)... , Feb. 24, 2017 Symic Bio, a ... a new category of therapeutics, announced today the completion ... in peripheral artery disease. The trial will evaluate the ... therapeutic, in the reduction of restenosis following angioplasty. ... development milestone for SB-030," said Nathan Bachtell , ...
Breaking Biology Technology: