Navigation Links
Study provides insight into pathway linked to obesity
Date:1/5/2010

A new study involving the University of Iowa, Mayo Clinic and two other institutions provides insight on weight control, suggesting that a ATP-sensitive potassium channel critical to survival and stress adaptation can contribute to fat deposition and obesity.

The investigation reveals how the ATP-sensitive potassium channel in the heart and skeletal muscles affects the balance between food intake and energy used. The study, which was done in animal models, appears in the January issue of the journal Cell Metabolism.

The collaborative study involved lead author Alexey Alekseev, Ph.D., assistant professor at Mayo Clinic, as well as scientists from the University of Connecticut and New York University School of Medicine.

The findings point to a potential pathway through which to manage and prevent obesity, said Leonid Zingman, M.D., senior study author and assistant professor of internal medicine at the University of Iowa, who began the research while at Mayo Clinic in the laboratory of Andre Terzic, M.D.

"We were interested in better understanding how energy balance is regulated, and so we focused on the ATP-sensitive potassium channel in muscles," Zingman said. "This ion channel, which is present in many tissues, had been studied extensively, but its role in heart and skeletal muscle function under normal, not stressed, conditions has not been previously understood.

"Our work indicates that the channel limits how certain muscle cells, called myocytes, use energy under normal workload conditions," Zingman added.

When researchers disrupted the channel's function in muscles of mice, the mice used more energy and became lean even while on a high-fat diet. In essence, the mice became resistant to obesity. However, this resistance to obesity was achieved at the cost of reduced endurance.

"Indeed, disrupting the channel made the mice burn more calories even while at rest and also made them less fuel efficient when exercising, and therefore less capable of maintaining physical performance," Zingman said. "Through evolution, living organisms have become energy-saving. They responded to limited food resources and the high energy need to survive by becoming energy efficient.

"But now, with excess food supply and an inactive lifestyle, this energy efficiency is a problem for humans," Zingman added.

The researchers are interested in whether it is possible to interfere with this "biological perfection" to manage obesity without negatively affecting heart and muscle function.


'/>"/>

Contact: Becky Soglin
becky-soglin@uiowa.edu
319-356-7127
University of Iowa
Source:Eurekalert

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... of Infosys (NYSE: INFY ), and Samsung SDS, ... partnership that will provide end customers with a more ... payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ) ... financial services, but it also plays a fundamental part in ...
(Date:4/15/2016)... 2016  A new partnership announced today will ... decisions in a fraction of the time it ... high-value life insurance policies to consumers without requiring ... Force Diagnostics, rapid testing (A1C, Cotinine and HIV) ... pressure, weight, pulse, BMI, and activity data) available ...
(Date:3/31/2016)... , March 31, 2016  Genomics firm Nabsys ... founding CEO, Barrett Bready , M.D., who returned ... of the original technical leadership team, including Chief Technology ... of Product Development, Steve Nurnberg and Vice President of ... to the company. Dr. Bready served as ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016  The Prostate Cancer Foundation (PCF) is ... treatments and faster cures for prostate cancer. Members of the Class of 2016 ... countries. Read More About the Class of 2016 PCF ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, ... of the Supplyframe Design Lab . Located in Pasadena, Calif., the Design ... of how hardware projects are designed, built and brought to market. , The ...
(Date:6/23/2016)... LOUISVILLE, Ky. , June 23, 2016 /PRNewswire/ ... from two Phase 1 clinical trials of its ... double-blind, placebo-controlled, single and multiple ascending dose studies ... and pharmacodynamics (PD) of subcutaneous injection in healthy ... APL-2 subcutaneously (SC) either as a single dose ...
(Date:6/23/2016)... On Wednesday, June 22, 2016, the NASDAQ Composite ... Jones Industrial Average edged 0.27% lower to finish at 17,780.83; ... has initiated coverage on the following equities: Infinity Pharmaceuticals Inc. ... NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ARLZ ), ... more about these stocks by accessing their free trade alerts ...
Breaking Biology Technology: