Navigation Links
Study provides insight into pathway linked to obesity
Date:1/5/2010

A new study involving the University of Iowa, Mayo Clinic and two other institutions provides insight on weight control, suggesting that a ATP-sensitive potassium channel critical to survival and stress adaptation can contribute to fat deposition and obesity.

The investigation reveals how the ATP-sensitive potassium channel in the heart and skeletal muscles affects the balance between food intake and energy used. The study, which was done in animal models, appears in the January issue of the journal Cell Metabolism.

The collaborative study involved lead author Alexey Alekseev, Ph.D., assistant professor at Mayo Clinic, as well as scientists from the University of Connecticut and New York University School of Medicine.

The findings point to a potential pathway through which to manage and prevent obesity, said Leonid Zingman, M.D., senior study author and assistant professor of internal medicine at the University of Iowa, who began the research while at Mayo Clinic in the laboratory of Andre Terzic, M.D.

"We were interested in better understanding how energy balance is regulated, and so we focused on the ATP-sensitive potassium channel in muscles," Zingman said. "This ion channel, which is present in many tissues, had been studied extensively, but its role in heart and skeletal muscle function under normal, not stressed, conditions has not been previously understood.

"Our work indicates that the channel limits how certain muscle cells, called myocytes, use energy under normal workload conditions," Zingman added.

When researchers disrupted the channel's function in muscles of mice, the mice used more energy and became lean even while on a high-fat diet. In essence, the mice became resistant to obesity. However, this resistance to obesity was achieved at the cost of reduced endurance.

"Indeed, disrupting the channel made the mice burn more calories even while at rest and also made them less
'/>"/>

Contact: Becky Soglin
becky-soglin@uiowa.edu
319-356-7127
University of Iowa
Source:Eurekalert

Page: 1 2

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... many of the roughly 156,000 gas stations across ... in parts of underground gas storage tankscorrosion that ... groundwater, a source of drinking water. In recent ... many rapidly corroding gas storage tank components such ... with use of gasoline-ethanol blends and the presence ...
(Date:7/31/2014)... 31, 2014 -- Do people make a rational choice ... them that way? Is it a matter of genetics?, ... a colleague from Rice University say that neither conscious ... lean left while others lean right. , A growing ... psychology are at the core of political differences, the ...
(Date:7/31/2014)... the Rim Fire was in full fury, raging swiftly ... entered the backcountry of Yosemite National Park in California,s ... park, the battle began to turn, enacting a case ... combine to fuel large, severe fires. , "When the ... where fire had been used as a management tool, ...
Breaking Biology News(10 mins):NIST corrosion lab tests suggest need for underground gas tank retrofits 2Scientists find growing consensus: Political attitudes derive from body and mind 2The Rim Fire 1 year later: A natural experiment in fire ecology and management 2The Rim Fire 1 year later: A natural experiment in fire ecology and management 3The Rim Fire 1 year later: A natural experiment in fire ecology and management 4The Rim Fire 1 year later: A natural experiment in fire ecology and management 5
... developing bipolar disorder depends in part on the combined, small ... brain, none of which is powerful enough to cause the ... the enzyme produced by one of these genes could lead ... was conducted by scientists at the National Institutes of Health's ...
... their effects on fat development, researchers have discovered that ... mice without some of the side effects attributed to ... harmine, was first isolated more than 150 years ago ... around the world, the team reports in the May ...
... it express who we are, but is it really possible to ... to that question seems to be related to fashion and glamour, ... Mexico and the Buck Institute in the USA, were able to ... In biology, the capacity to establish the function of a molecule, ...
Cached Biology News:Genetic roots of bipolar disorder revealed by first genome-wide study of illness 2Genetic roots of bipolar disorder revealed by first genome-wide study of illness 3Fat screen delivers plant-derived chemical with antidiabetic effects 2
(Date:7/31/2014)... to see through organs and even the entire body ... fine-grained cellular structures has been a long-time dream of ... July 31st in the journal Cell has ... for making opaque organs, bodies, and human tissue biopsies ... The protocols could pave the way for a better ...
(Date:7/31/2014)... Ind. -- Chemists at Indiana University Bloomington have ... bricks-and-mortar fashion, a development with potential value for ... field-effect transistors and photovoltaic cells. , Their paper, ... Crystalline Solids and 2D Self-Assembled Crystals," has been ... journal of the Royal Society of Chemistry. It ...
(Date:7/31/2014)... According to a new market ... - Global Industry Analysis, Size, Share, Growth, Trends and ... USD 88.5 million in 2011, which is expected to ... CAGR of 53.8% from 2013 to 2023. ... Increasing demand for energy efficient displays ...
(Date:7/31/2014)... Yonkers, NY (PRWEB) July 31, 2014 ... use in high temperature oven carts. These bearings are ... occur in sealed ball bearings because of the ... purity alumina requested help from the design engineers at ... through a heating process. During their manufacturing operation, pans ...
Breaking Biology Technology:See-through organs and bodies will accelerate biomedical discoveries 2Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 2Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 2Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 4Graphite Metallizing Announces Bearings for High Temperature Oven Applications 2Graphite Metallizing Announces Bearings for High Temperature Oven Applications 3
... 31, 2012  bioTheranostics, Inc., a bioMerieux company that ... treatment, has introduced a new product line of ... pathway interrogation called PRECIS Precision Medicine by bioTheranostics(SM). ... partners accurate diagnosis of primary tumor site and ...
... rap music can be harnessed to power a new type ... body. Acoustic waves from music, particularly rap, were found ... ultimately help to treat people stricken with aneurisms or incontinence ... a vibrating cantilever, a thin beam attached at one end ...
... The technique builds on previous research in which microbubbles were ... produce an oil which can be processed to create a ... important alternative to fossil fuels and algae, in particular, has ... now, however, there has been no cost-effective method of harvesting ...
Cached Biology Technology:bioTheranostics Launches Precision Medicine Biomarkers for Tumor Pathway Interrogation 2bioTheranostics Launches Precision Medicine Biomarkers for Tumor Pathway Interrogation 3Rap music powers rhythmic action of medical sensor 2Rap music powers rhythmic action of medical sensor 3Microbubbles provide new boost for biofuel production 2
UGT1A7 (E-15)...
Chicken Aortic Smooth Muscle Cells (CAOSMC) (>500,000 cells)...
... Hot Start Taq ... activity before the onset ... nonspecific amplification and primer-dimer ... is raised, the antibody ...
... UV irradiation and antimicrobial stainless steel to ... Quickly inactivate DNA between experiments with ... with antimicrobial coated stainless steel ... built-in 30-minute timer UVP's Sterilizing ...
Biology Products: