Study proposes new theory of how viruses may contribute...(erpesvirus or KSHV also known as human h...)

Date:10/23/2007

erpesvirus, or KSHV, also known as human herpesvirus 8 (HHV-8). The researchers examined a gene called K13 that activates a pathway previously implicated in cancer development. Cells with low K13 expression allowed KSHV to replicate, and these cells subsequently died off, the researchers noted. Cells with higher expression of K13 emerged after KSHV replication and showed defective expression of two key proteins that are known to promote cancer.

This paradigm, if validated by further studies, has implications not only for an improved understanding of the processes involved in cancer, but also for the development of effective strategies for its prevention and treatment, said Dr. Chaudhary.

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Contact: Clare Collins CollCX@upmc.edu 412-647-3555 University of Pittsburgh Schools of the Health Sciences Source:Eurekalert

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