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Study points to potential new drug for type 2 diabetes
Date:3/15/2010

am of body weight, showed the lowest levels of these proinflammatory cytokines.

Satoskar explained that the molecule in the drug binds to MIF in a way that allows it to strip MIF of its three-part structure, preventing MIF from become biologically active. MIF is always present in the body, but isn't considered problematic until excess amounts of it are produced and active. Though it might have some physiological role in normal amounts, blocking it or interfering with its activity does not appear to cause any side effects in animals, he said.

The researchers suspect MIF acts on adipocytes, the cells that make up fat tissue, because they also found that the mice lacking MIF showed significantly lower levels than normal diabetic mice of a hormone called resistin, which is produced by adipocytes and contributes to insulin resistance.

"Finding that mice without MIF have less resistin suggests that MIF might do its damage by acting on adipocytes and making them produce more inflammation," Satoskar said.

Because Type 2 diabetes is strongly associated with obesity, these cells also could be responsible for production of the inflammatory cytokines that were shown in this study to be elevated in mice and humans, he said.

He and colleagues next plan to test the investigational drug on mice that model obesity and typically develop Type 2 diabetes after eating a high-fat diet.


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Contact: Abhay Satoskar
satoskar.2@osu.edu
614-292-3243
Ohio State University
Source:Eurekalert

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