Navigation Links
Study points to potential new drug for type 2 diabetes
Date:3/15/2010

of this evidence combined suggests strongly that MIF is a viable therapeutic target in Type 2 diabetes," Satoskar said.

The study appears online and is scheduled for later print publication in the Journal of the Federation of American Societies for Experimental Biology.

This research applies only to non-insulin-dependent diabetes mellitus and not Type 1 diabetes, which occurs when the pancreas does not produce enough insulin. Not all people with Type 2 diabetes have a shortage of insulin, but their bodies do not respond correctly to the hormone.

Insulin is responsible for transferring sugar, or glucose, from the blood into the cells to be used for energy. When people become insulin resistant, the main characteristic of Type 2 diabetes, that process does not function properly, which tends to drive up blood sugar levels and starve cells of energy.

Many current diabetes drugs stimulate the body to release more insulin or otherwise act in a way that affects sensitivity to insulin. A drug targeting MIF could offer different benefits by lowering blood sugar and inflammation without the need to generate more insulin, Satoskar noted.

Satoskar and colleagues induced Type 2 diabetes in two groups of mice: normal mice and those lacking MIF. They induced the disease by injecting them one time with a naturally occurring toxin, streptozotocin, which acts on cells in the pancreas.

Researchers collected blood samples from the mice multiple times over 10 weeks, conducted oral glucose tolerance tests, and monitored their weight and urine output.

All animals with induced disease showed a spike in blood sugar levels shortly after the injection of the toxin, but the blood sugar levels continued to rise in the normal diabetic mice. These mice also took in more food, lost weight and produced excessive amounts of urine all symptoms associated with insulin resistance.

Mice lacking the MIF protein, on the oth
'/>"/>

Contact: Abhay Satoskar
satoskar.2@osu.edu
614-292-3243
Ohio State University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Study opens new avenue for developing treatments for genetic muscle-wasting disease
2. Clemson researcher receives grant to study engineering enrollment of women, minorities
3. VAI researchers develop tool to help study prostate cancer
4. Students perceptions of Earths age influence acceptance of human evolution, says U of Minn. study
5. Study finds that low-income women living in small cities have higher chance of obesity
6. ARS study provides a better understanding of how mosquitoes find a host
7. Musk ox population decline due to climate, not to humans, study finds
8. Study shows potential for using algae to produce human therapeutic proteins
9. Study identifies key cause of chronic leukemia progression
10. Study shows woody plant encroachment has increased stream flow in the Edwards Plateau
11. New study shows teens who drink 100 percent fruit juice have more nutritious diets overall
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/11/2015)... GOTHENBURG, Sweden , August 11, 2015 ... sensor FPC1155. Already received as well as expected revenues in 2015 ... included in FPC,s communicated revenue guidance of approximately 2,200 MSEK for ... is a prominent smartphone manufacturer ... ZUK selected FPC1 155 ...
(Date:8/6/2015)... JOSE, Calif. , Aug. 6, 2015 /PRNewswire/ ... leading developer of human interface solutions, today announced ... TouchPad technologies on Windows 10. Microsoft leveraged Synaptics, ... to the operating system. Through ... drivers are fully certified with Microsoft,s Precision TouchPad ...
(Date:8/4/2015)...  AMRI (NASDAQ: AMRI ) today reported financial and operating ... Highlights: , Second quarter contract revenue of $ ... , Adjusted contract margins of 26 % ... $0.05 decrease in EPS from royalties in the current quarter ... "We are very pleased to present another strong financial quarter, ...
Breaking Biology News(10 mins):FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2Synaptics Chosen for Human Interface Co-Development on Windows 10 2AMRI Announces Second Quarter 2015 Results 2AMRI Announces Second Quarter 2015 Results 3AMRI Announces Second Quarter 2015 Results 4AMRI Announces Second Quarter 2015 Results 5AMRI Announces Second Quarter 2015 Results 6AMRI Announces Second Quarter 2015 Results 7AMRI Announces Second Quarter 2015 Results 8AMRI Announces Second Quarter 2015 Results 9AMRI Announces Second Quarter 2015 Results 10AMRI Announces Second Quarter 2015 Results 11AMRI Announces Second Quarter 2015 Results 12AMRI Announces Second Quarter 2015 Results 13AMRI Announces Second Quarter 2015 Results 14AMRI Announces Second Quarter 2015 Results 15AMRI Announces Second Quarter 2015 Results 16AMRI Announces Second Quarter 2015 Results 17AMRI Announces Second Quarter 2015 Results 18AMRI Announces Second Quarter 2015 Results 19AMRI Announces Second Quarter 2015 Results 20AMRI Announces Second Quarter 2015 Results 21AMRI Announces Second Quarter 2015 Results 22AMRI Announces Second Quarter 2015 Results 23AMRI Announces Second Quarter 2015 Results 24
... at the American College of Cardiology's 55th Annual Scientific ... cholesterol lowering with a statin drug can regress (partially ... , This finding has never before been ... commonly used cholesterol lowering treatment. Previous research had indicated ...
... clinical research is being done, warns a senior doctor ... is failing patients and clinicians by neglecting this vital ... information that doctors need to diagnose and treat patients ... field of neurology alone, many examples exist where a ...
... new study by Rebecca Baggaley, Neil Ferguson, and Geoff ... epidemic in poor countries will not be controlled through ... As they demonstrate in an article in the open-access ... such as counseling patients and their communities about safe ...
Cached Biology News:Intensive statin therapy may partially reverse plaque build-up in arteries 2Access to antiretrovirals unlikely to reduce HIV infection rates 2
(Date:8/27/2015)... ... August 27, 2015 , ... The Kansas City Animal ... and animal health companies to hear from animal health companies with the newest ... received licensing agreements or distribution contracts. This meeting is one of the ...
(Date:8/27/2015)... MENLO PARK, Calif. , Aug. 27, 2015 /PRNewswire/ ... company in the emerging field of regenerative medicine, today ... two investor conferences in the month of September.  ... Officer, will present at Rodman & Renshaw,s 17th Annual ... 10:25am ET/7:25am PT at the St. Regis Hotel in ...
(Date:8/27/2015)... ... August 27, 2015 , ... METTLER ... expertly narrows down the product choices to a manageable shortlist of bench and ... list to models that fit best with the customer’s industry and application. ...
(Date:8/26/2015)... , Aug. 26, 2015  Roka Bioscience, Inc. (NASDAQ: ... providing advanced testing solutions for the detection of foodborne ... present at the Sidoti & Company Emerging Growth Conference ... be held at the New York Marriott Marquis. ... be available through the investor relations section of Roka ...
Breaking Biology Technology:VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 2VetStem Biopharma, Inc. Among Seventeen Companies Selected to Present at the KC Animal Health Investment Forum on September 1st 2015 3Asterias Biotherapeutics to Present at Upcoming Investor Conferences 2METTLER TOLEDO Updates Online Scale Selection Tool 2
... at Northwestern Universitys Center for Quantum Devices (CQD) ... detecting single photons in the ultraviolet region (360-200 ... only available technology in the short wavelength UV ... detection sensitivity. However, these fragile vacuum tube devices ...
... published,"Thought Leader Insight & Analysis: Alzheimer,s Disease," designed ... companies with a,stake in the market for diagnostics ... the size of this patient population and the ... is not surprising to see the,large number of ...
... Better Option for Humans, EGG HARBOR TOWNSHIP, ... first time, The British Institute of Homeopathy, U.S.A. ... U.S. medical and,homeopathic practitioners for a low-introductory cost ... therapy is more advantageous because,it does not carry ...
Cached Biology Technology:Tiny avalanche photodiode detects single UV photons 2New Report Tackles the Changing Landscape for Alzheimer's Diagnostics and Treatments 2
The 12-Tube Magnetic Separation Rack is designed to be used for small-scale separations using magnetic particles. ,Capacity: 12 microcentrifuge tubes. ,Magnets: Neodymium rare earth permanent ma...
DONOR BOVINE SERUM AND PLASMA...
12(S)-HETE-d8 is used as an internal standard for the quantification of 12(S)-HETE by stable isotope dilution mass spectrometry....
...
Biology Products: