Navigation Links
Study points to new uses, unexpected side effects of already existing drugs
Date:11/4/2009

CHAPEL HILL Scientists at the University of North Carolina at Chapel Hill School of Medicine and the University of California, San Francisco have developed and experimentally tested a technique to predict new target diseases for existing drugs.

The researchers developed a computational method that compares how similar the structures of all known drugs are to the naturally occurring binding partners -- known as ligands -- of disease targets within the cell. In a study published this week in Nature, the scientists showed that the method predicts potential new uses as well as unexpected side effects of approved drugs.

"This approach uncovered interactions between drugs and targets that we never could have predicted simply by looking at the chemical structures," said senior study author Bryan Roth, M.D., Ph.D., professor of pharmacology and director of the National Institute of Mental Health Psychoactive Drug Screening Program at UNC. "We may now have a way to predict what side effects are likely to occur from treatment before we even put a drug into clinical testing." Roth is also a member of the UNC Lineberger Comprehensive Cancer Center.

Many of the most successful drugs on the market today are being prescribed for ailments that are quite different from the ones they were originally designed to treat. Viagra, for instance, was once intended for coronary heart disease but now is used to combat erectile dysfunction. The discovery of surprising uses of developed drugs can sometimes be the result of serendipity, as unforeseen side effects emerge from clinical trials. In the past, researchers have tried to predict drug interactions by looking for chemical similarities among the possible targets of pharmaceutical compounds.

However, some drug targets which look very similar to one another bind very different ligands, and some targets that don't have any obvious similarity bind similar ligands, says Brian Shoichet, P
'/>"/>

Contact: Les Lang
llang@unch.unc.edu
919-966-9366
University of North Carolina School of Medicine
Source:Eurekalert  

0

GOOD

Page: 1 2

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk

Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study points to new uses, unexpected side effects of already existing drugs
Study points to new uses, unexpected side effects of already existing drugs
(Date:11/22/2009)...renatally to tobacco smoke and during childhood to...rding to research done at Cincinnati Children,s Ho...t up to 35 percent of ADHD cases in children betwe...ating both of these environmental exposures. This ...Tobacco and lead exposure each have their own impo...
(Date:11/22/2009)...2009 -- A butterfly,s proboscis looks like a straw...works more like a paper towel, according to Konsta...row the tricks of this piece of insect anatomy to ... of cells. , Kornev will present his work next w...sical Society,s (APS) Division of Fluid Dynamics w...
(Date:11/20/2009)...n many scientific and technological frontiers. The... support that totals nearly $4.3 million for the d...r the American Recovery and Reinvestment Act of 20...s for investigation of solar phenomena. Philip R. ...hance the capabilities of NJIT,s Big Bear Solar Ob...
Breaking Biology News(10 mins):Exposure to lead, tobacco smoke raises risk of ADHD 2NJIT receives NSF funding to improve Big Bear Telescope, study solar energy 2Researchers Find Common Respiratory Virus Hijacks Lung Cells to Stay Alive 4946 1Researchers Find Common Respiratory Virus Hijacks Lung Cells to Stay Alive 4946 2Researchers Find Common Respiratory Virus Hijacks Lung Cells to Stay Alive 4946 3Young Animals May Be Able to Erase Bad Memories 56289 1Young Animals May Be Able to Erase Bad Memories 56289 2Newly Formed American Society for Nanomedicine 28ASNM 29 to Hold First Conference 28www amsocnanomed org 29 56285 1Newly Formed American Society for Nanomedicine 28ASNM 29 to Hold First Conference 28www amsocnanomed org 29 56285 2
...idens. Called granulosa cells, they surround eggs ...osa cells, eggs cannot mature and be successfully ...gists at Brown University and the University of Ca...s ?TAF4b and c-Jun ?team up to turn on about two d...his subset of genes, in turn, writes the genetic c...
...k fish" and fishermen,s nets will be hauling in ev...on to stem the global tide of over fishing, says a...sh Columbia. Dr. Daniel Pauly says the crisis in t...f than about attitude and political will. , And, ...file political champion like a Bono or Mandela to ...
...t wildlife biologists have with wolverines in the ...tracks in the snow. But wildlife biologist Keith A...ted for several weeks. , A member of his research...ade Range of Washington to report that a wolverine... and research wildlife biologist at the U.S. Fores...
Other Biology News:A surprising pair of proteins help make healthy eggs 2Hooked on fishing, and we're heading for the bottom, says scientist 2Hooked on fishing, and we're heading for the bottom, says scientist 3First wolverine radio-collared in Pacific Northwest 2
(Date:11/19/2009)...FirstCall/ -- Spherix Incorporated (Nasdaq: SPEX ...apy, and a provider of technical and regulatory co...gy and pharmaceutical companies, today announced t...ders. ,, At the meeting, shareholders of Spheri...ing members to the Board of Directors: ,, Doug...
(Date:11/19/2009)...nd recognized refractive and cataract surgery expe...their fellow surgeons up-to-date on the latest dev...urgery, and ophthalmology in general at the recent...O) annual meeting in San Francisco, California. Dr... Huang, MD, Dr. Randy Epstein, Dr. William Trattle...
(Date:11/18/2009)...-- Marrone Bio Innovations (MBI), a leader in the ...fective and environmentally responsible pest manag...n IC20 company by the Investors, Circle, the Unite...ing group. ,, Companies named to the IC20 excel...ll stakeholders, including investors, the environm...
(Date:11/18/2009)... developing new sensors to detect chemical agents ...inst the threat of terrorist attacks. , The devi...dual or crime scene to gather a sample which is th...ct the presence of chemicals within seconds. This ...response to terrorist threats. , The scanning i...
Breaking Biology Technology:Spherix Announces Results of Annual Shareholders Meeting 2Spherix Announces Results of Annual Shareholders Meeting 3Spherix Announces Results of Annual Shareholders Meeting 4Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 2Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 3Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 4Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 5Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 6Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 7Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 8Experts Listed at Trusted LASIK Surgeons Bring Peers Up to Date on Vision Correction and Cataract Surgery at Annual AAO Meeting 9Marrone Bio Innovations Named an IC20 Company 2New technology detects chemical weapons in seconds 2
...rrently in orbit and the National Aeronautics and ...ram, scientists have been able to observe the Eart...ous disease outbreaks around the world. The use o...edicting the outbreak of some of the most common a... West Nile virus and Rift Valley Fever. The abili...
... of the National Nanotechnology Initiative has jus...ce, Engineering, and Technology (NSET) Subcommitte...Committee on Technology with support from the Nati...The 2007 NNI Strategic Plan describes the vision, ...e United States derives growing economic benefits ...
...hairman of the Board S. Colin ...mos Corporation,(Nasdaq: PARS ) announced today c...ement, effective immediately., Board Changes, Ro...Executive Chairman., Haim Aviv, Ph.D., David Schl...., The Pharmos Board now consists of seven direct...
Other Biology Technology:NASA technology helps predict and prevent future pandemic outbreaks 2National Nanotechnology Initiative releases new strategic plan 2National Nanotechnology Initiative releases new strategic plan 3Pharmos Corporation Announces Board and Management Changes 2Pharmos Corporation Announces Board and Management Changes 3
Mouse Anti-Kusabira Orange Monoclonal Antibody, Unconjugated, Clone 2G9 from MBL International
Goat Anti-SPFH2 Polyclonal Antibody, Unconjugated from Abcam
Goat Anti-Als2 Polyclonal Antibody, Unconjugated from Abcam
Mouse Anti-Kusabira Orange Monoclonal Antibody, Unconjugated, Clone 2G9 from MBL International
Biology Products: