Navigation Links
Study points to key genetic driver of severe allergic asthma
Date:8/29/2010

esence of IL-17A proteins in human asthma but no apparent role. Earlier research involving mouse models of the disease has suggested possible roles for IL-17A in asthma, and this study expands on those findings.

The current study involved mice bred genetically to closely resemble people susceptible to severe asthma. Mouse airways were exposed to house dust mite allergen extract to gauge the severity of disease and analyze biochemical responses in airway tissues.

One group of mice was deficient in the immune system gene C5, which normally prevents harmful airway immune responses to inhaled environmental allergens. These mice generated high numbers of T helper cells (known specifically in this instance as TH17 cells) that produced significant IL-17A and caused airway hyper-responsiveness. When researchers blocked IL-17A production in this group, the mice had less airway hyper-responsiveness.

A second group of mice was deficient in the C3aR gene (a receptor for C3), which regulates the dysfunctional response to airway allergens that lead to asthma. These mice had fewer IL-17A producing TH17 cells and less airway hyper-responsiveness. When researchers increased the amount of IL-17A in the airways of this group, the mice experienced greater airway hyper-responsiveness.

As Dr. Wills-Karp and her colleagues continue their research, they will study the relationship between C3 and IL-17A in severe asthmatics, and explore the effectiveness of targeting either the C3 or IL-17A pathways for the treatment of severe asthma. A drug that blocks the function of C3 is currently under development and testing outside of Cincinnati Children's for treatment of the eye disease macular degeneration.


'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Neuronal diversity makes a difference, says Carnegie Mellon study
2. Jefferson receives $3 million NIH grant to study molecular and genetic mechanisms in platelets
3. Texas A&M research produces tools to study stallions subfertility
4. UCI-Scripps study links cellular motors to memory
5. Coral off Puerto Ricos coast ideal case study for Gulf oil spills impact
6. Microneedle, quantum dot study opens door to new clinical cancer tools
7. New study shows how giant tortoises, alligators thrived in High Arctic 50 million years ago
8. USDA-backed study finds federal school lunches linked to childhood obesity
9. New study sheds light on painkilling system in brain
10. Researchers study cinnamon extracts
11. UF study shows carnivore species shrank during global warming event
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2015)...  TAKE Solutions Ltd., a global business technology solutions ... Patent and Trademark Office (USPTO) for its "Method for ... Clinical Accelerators to reduce the time taken to standardize ... without the accelerators), thus reducing time to market. ... the heart of the patented Clinical Data Standardization Process ...
(Date:6/24/2015)... June 24, 2015 Biometry authentication provider ... biometric password solution one face in. ... one face in, entering the expanding biometric ... affordable multifactor-authentication biometric answer to the password problem. ... in partnership with KeyLemon, one face in allows ...
(Date:6/18/2015)... NEW YORK , June 18, 2015 ... in US$ Million by the following Product Segments, which ... Immunoassay Systems, Chemiluminescence Immunoassay Systems, Radio Immunoassay Systems, and ... for the US, Canada , ... Asia-Pacific , Latin America ...
Breaking Biology News(10 mins):TAKE Solutions Awarded Patent By USPTO 2KeyLemon Announces Partnership With Biometric Password Solution onefacein 2Global Immunoassay Systems Market 2Global Immunoassay Systems Market 3Global Immunoassay Systems Market 4Global Immunoassay Systems Market 5Global Immunoassay Systems Market 6Global Immunoassay Systems Market 7Global Immunoassay Systems Market 8Global Immunoassay Systems Market 9Global Immunoassay Systems Market 10Global Immunoassay Systems Market 11Global Immunoassay Systems Market 12Global Immunoassay Systems Market 13Global Immunoassay Systems Market 14Global Immunoassay Systems Market 15Global Immunoassay Systems Market 16Global Immunoassay Systems Market 17Global Immunoassay Systems Market 18Global Immunoassay Systems Market 19Global Immunoassay Systems Market 20Global Immunoassay Systems Market 21Global Immunoassay Systems Market 22Global Immunoassay Systems Market 23Global Immunoassay Systems Market 24Global Immunoassay Systems Market 25Global Immunoassay Systems Market 26Global Immunoassay Systems Market 27Global Immunoassay Systems Market 28Global Immunoassay Systems Market 29
... the oceans, gut microbes and STIs are just some ... be covered next week at the Society for General ... and Micro-organisms, the event takes place 29 March-1 April, ... experts deliver talks in an exciting mixture of symposia, ...
... three genes that could shed light on the genetic causes ... stroke. Researchers at the University of Edinburgh have discovered ... long it takes blood to clot. The team thinks ... could help further our understanding of conditions such as deep ...
... WI, March 22nd, 2010-Riparian areas, ecosystems caught between ... spatial and temporal variability. Effectively managing and protecting ... understanding these concepts. Fortunately, scientists are investigating new ... experiences. One of those approaches is photography. ...
Cached Biology News:Top microbiology experts meet in Edinburgh at SGM Spring Conference 2010 2Study finds genes that keep watch on blood clotting time 2Learning about riparian areas from photographs 2
(Date:7/7/2015)... ... July 07, 2015 , ... bioLytical Laboratories Inc. ... Test was accepted for presentation at the 8th Annual International AIDS Society (IAS) ... presented Wednesday, July 22nd from 1:00 pm to 2:00pm Pacific Standard Time at ...
(Date:7/7/2015)... 7, 2015  SME,s Advanced Manufacturing Media is proud ... 30" issue, celebrating young men and women who have ... July issue of Manufacturing Engineering ... for their accomplishments. Among the standouts: Christopher Tyler ... on optimizing the topology of flapping wing vehicles; ...
(Date:7/7/2015)... ... July 07, 2015 , ... The global aptamers market is ... at a CAGR of 17.89% between 2015 and 2020. The aptamer type segments ... on applications, the report is segmented into diagnostics, therapeutics development, R&D, and other ...
(Date:7/7/2015)... ... July 07, 2015 , ... Currently deployed ... was developed to solve many of the complex logistical and data management ... involve multiple clinical sites and/or remote data coordination centers. , CentrePoint drastically ...
Breaking Biology Technology:bioLytical to Present Findings of Early HIV Detection 2bioLytical to Present Findings of Early HIV Detection 3SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 2SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 3SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 4SME's Advanced Manufacturing Media Recognizes "30 Under 30" Future Leaders of Manufacturing 5Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 2Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 3Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 4Aptamers Market Growing at 17.89% CAGR to 2020 – New Research Available at RnRMarketResearch.com 5ActiGraph Launches CentrePoint Cloud-based Study Management Software Platform 2ActiGraph Launches CentrePoint Cloud-based Study Management Software Platform 3
... an invitation for reflection, and this one is no different. These ... and well no doubt look back on 2005 and pronounce it ... the overall scheme of things, the previous four years were a ... Sure, it stung like hell and a lot was lost on ...
... promised, our latest e-mail newsletter contains the most-read stories from our ... around 30,000 visitors a month to over 70,000 last month, many ... weve paid attention to what drew your interest. , ,Let ... for Fusion2006. The conference isnt until March 2 and were more ...
... of health care in the United States are enough to ... one in seven Americans (15.7 percent) lack health insurance. Thats ... the latest federal figures, health spending accounts for 15.3 percent ... in 2003 works out to $5,670 for each American. By ...
Cached Biology Technology:2005: the year of the comeback 22005: the year of the comeback 3Health care economics make definition of 'cost' problems difficult 2Health care economics make definition of 'cost' problems difficult 3
... Serum is obtained from ... from healthy, fasted donors. The ... any way and are maintained ... Total Protein Concentration : ...
Hamster serum...
... 96-well Filter Plates are offered in several ... um depth filter plates are ideal to ... Filtration is simple, versatile, and necessary to ... Captiva 10 um glass fiber and 20 ...
... Kit with CyScribe GFX Purification Kit, ... purification of Cy3- and Cy5-labeled cDNA.Optimized ... cDNA labeling and purification.Flexible and optimized ... labeling reactions with either Cy3- or ...
Biology Products: