Navigation Links
Study points to essential role of IL-22 in lung repair after the flu
Date:3/10/2013

Philadelphia, PA, March 11, 2013 Once the initial episode of influenza has passed, the chronic effects tend to be overlooked. The results of a new study indicate that the cytokine interleukin-22 (IL-22) plays a critical role in normal lung repair following influenza infection. This study is published in the April 2013 issue of the American Journal of Pathology.

"With the increasing prevalence of more infective and/or virulent strains of influenza, understanding the impact of virus on the host epithelium and the processes involved in lung repair are of great importance," says John F. Alcorn, PhD, an immunologist affiliated with the department of pediatrics at the Children's Hospital of Pittsburgh of UPMC. He notes that the findings open up new possibilities for developing therapeutic agents that promote recovery of normal lung function and architecture after influenza infection and lessen the likelihood of secondary infections. "A key finding is that even after the resolution of infection, influenza results in lung parenchymal remodeling that may be critical to susceptibility to further injury," says Dr. Alcorn.

This series of experiments used 6- to 8-week-old wild-type (WT) mice (C57BL/6 strain) as well as IL-22deficient mice, infected with influenza A PR/8/34 H1N1 or control vehicle. To determine the distribution of IL-22 in the lung, they used immunohistochemistry for the high affinity IL-22Ra1 receptor. Investigators found that in WT mice not inflected with influenza, IL-22 receptors were distributed on epithelial cells of the large and small airways, but not within the parenchyma. They noted that this receptor distribution suggests that in the absence of lung injury, IL-22 interacts mainly with the bronchial epithelial cells.

By 21 days post influenza infection, IL-22 receptors were observed in parenchymal tissue in injured areas, such as alveoli under repair. Researchers suggest that the IL-22 receptor can be upregulated
'/>"/>

Contact: David Sampson
ajpmedia@elsevier.com
215-239-3171
Elsevier Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Intermountain study finds length of DNA strands can predict life expectancy
2. Genetic study of house dust mites demonstrates reversible evolution
3. Bats not bothered by forest fires, study finds
4. International study: Excess dietary salt may drive the development of autoimmune diseases
5. Study pinpoints, prevents stress-induced drug relapse in rats
6. Assembling the transcriptome of a noxious weed: New resources for studying how plants invade
7. Study uncovers enzymes double life, critical role in cancer blood supply
8. Study maps human metabolism in health and disease
9. Volcanic aerosols, not pollutants, tamped down recent Earth warming, says CU-Boulder study
10. Study provides insights into plant evolution
11. New study reveals how sensitive US East Coast regions may be to ocean acidification
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... SPRINGS, Florida , July 25, 2014 ... as more consumers are turning to digital technology for ... Inc. (OTCBB: NXTD), Google Inc. (NASDAQ: GOOG ... Inc. (NYSE: V ), Apple Inc. (NASDAQ: ... NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication ...
(Date:7/24/2014)... -- The Geneva Healthcare Suite, an innovative technology platform ... room wait times by an average of 92 minutes ... to a recent study published in the Academic Emergency ... suite to access data from incoming patients, implanted cardiac ... Geneva,s technology platform we have been able to quickly ...
(Date:7/24/2014)... different effects on different species of fish, according ... Bristol and Exeter which tested fish anti-predator behaviour. ... flying seagull predator model when exposed to additional ... minnows. , Lead author Dr Irene Voellmy ... levels in many aquatic environments have increased substantially ...
Breaking Biology News(10 mins):Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 2Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 3Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 4Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 5Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 6UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 2UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 3
... America is pleased to announce that nine students, research ... Annual Drosophila Research Conference in Washington, D.C., April 7-11, ... place awards for each of three academic levels: postdoctoral, ... undergraduate student research was included for review to receive ...
... Disadvantaged urban preschoolers aren,t only at risk for failure in ... and athletic fields as well, research suggests. A new ... disadvantaged preschoolers from two urban areas showed significant developmental delays ... catching. That means that they are at risk of ...
... capturing the sun,s rays through solar panels on their roofs used ... in order to help save the planet. But now there is ... eyesore, says a Spanish-German partnership, which has developed a virtually invisible ... "You don,t see the film at all it,s marvellous," says ...
Cached Biology News:Genetics Society of America announces award recipients at 51st Annual Drosophila Conference 286 percent of disadvantaged preschoolers lack basic motor skills 286 percent of disadvantaged preschoolers lack basic motor skills 3Roof integrated solar energy 2Roof integrated solar energy 3
(Date:7/24/2014)... , July 24, 2014  CorMedix Inc. (NYSE ... and commercializing therapeutic products for the prevention and ... receipt of notice on July 18, 2014 from ... has accepted the CorMedix plan to regain compliance ... a result, the NYSE-MKT is continuing the Company,s ...
(Date:7/24/2014)... Mich. , July 24, 2014  Neogen Corporation ... that future forecasts of its potential revenue from new ... call to investors and analysts on July 22, 2014, ... by analysts regarding this research. "It was ... questions about the potential of a new type of ...
(Date:7/24/2014)... The first part of the session on ... Human Studies” will cover comprehensive clinical support in early ... increasing R&D costs and declining industry success in getting ... knowledge collected in early Phase I/IIa study data to ... stage development. , Next, the presenters will examine steps ...
(Date:7/24/2014)... , July 24, 2014   Cypher ... today the appointment of Adam Simpson ... Genomics provides rapid and comprehensive annotation and interpretation ... clinical reporting. "Cypher,s technology has the ... healthcare by enhancing diagnostic accuracy, optimizing therapeutic approaches ...
Breaking Biology Technology:CorMedix, Inc. Granted Extension of NYSE-MKT Listing 2CorMedix, Inc. Granted Extension of NYSE-MKT Listing 3Neogen comments on SenesTech 2Best Practices for Optimizing Dose Escalation in First in Human Studies, New Webinar August 6th Hosted by Xtalks 2Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 2Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 3
... MADISON First, a full disclosure: Ive been hawking the concept ... a couple of years, so its no surprise I would think ... finding common ground. , ,Then again, its still something of ... dont have to be a student of Wisconsin history to know ...
... - There is both a new World Wide Web ... branding/marketing professionals would be wise to adapt to, according to ... conference, which is being held at Monona Terrace , ... era where technology has helped put the consumer in charge. ...
... When there was a monopoly phone service prior to the ... "give exclusivity in the territory and we will provide universal ... to a geographic subscriber base, the traditional phone companies ensured ... a fair price. There was one price across the board. ...
Cached Biology Technology:A (modern) Tale of Two Cities: Milwaukee and Madison inch together 2A (modern) Tale of Two Cities: Milwaukee and Madison inch together 3Marketers advised to engage "search economy" 2Marketers advised to engage "search economy" 3Does redefining universal service help bridge the digital divide? 2Does redefining universal service help bridge the digital divide? 3Does redefining universal service help bridge the digital divide? 4Does redefining universal service help bridge the digital divide? 5
... Chromogen system consists of [5-Bromo-4-Chloro-3-,Indolyl ... a single component,solution. The ready-to-use ... presence of alkaline phosphatase to ... minimal background noise. ,The System ...
... Corning CellBIND surface is produced by a ... hydrophilic surface giving more consistent, even cell ... enhances cell attachment and growth uunder difficult ... • CellBIND may provide a more ecominic ...
SphingoStripsTM contain fifteen different biologically active, nitrocellulose-immobilized lipids at 100 pmol per spot, which can be assayed for protein binding and specificity using a simple blot ove...
... Ion Channel Cell Lines ,High Quality, Functionally-Validated, ... are well known for having a critical ... consequently have a key function in pain, ... ion channels have been investigated in therapeutic ...
Biology Products: