Navigation Links
Study pinpoints genetic variation that raises a risk linked to bisphosphonates
Date:1/27/2012

ing to the American College of Rheumatology. ONJ is more common among cancer patients taking the intravenous form of the drug, affecting about 5 to 10 percent of these individuals, noted Dr. Zavras.

Studies have suggested that genetic factors play a major role in predisposing patients to ONJ. Delving deeper into this question, Dr. Zavras and his colleagues performed genome-wide analyses of 30 patients who were taking bisphosphonates and had developed ONJ and compared them with several bisphosphonate users who were disease free.

The researchers found that patients who had a small variation in the RBMS3 gene were 5.8 times more likely to develop ONJ than those without the variation. The study also identified small variations in two other genes, IGFBP7 and ABCC4, that may contribute to ONJ risk.

"Our ultimate goal is to develop a pharmacogenetic test that personalizes risk assessment for ONJ, a test that you could give to people before they start to use bisphosphonates," said Dr. Zavras. "Those who are positive for this genetic variation would select some other treatment, while those who are negative could take these medications with little fear of developing ONJ."

"At the moment, many women discontinue or avoid treatment for serious osteoporosis because they are afraid of losing their jaw bones," added Dr. Zavras. "There even are reports of dentists who have refused to perform certain invasive procedures in patients taking bisphosphonates. So there is a great need for a pharmacogenetic screening test to determine which patients are really at risk for ONJ."

The current study looked only at Caucasians. Further studies are needed to determine whether the RBMS3 gene variation is seen in other racial groups, according to the researchers.

The paper is entitled, "Genome-wide pharmacogenetics of bisphosphonate-induced osteonecrosis of the jaw: the role of RBMS3." The lead authors are Paola Nicoletti of CUMC and Vass
'/>"/>

Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UMass Amherst ecologists among the first to record and study deep-sea fish noises
2. Coastal storms have long-reaching effects, study says
3. Recent study by Mars, Incorporated and partners underscores importance of metabolism in understanding health benefits of cocoa flavanols
4. Pycnogenol (French maritime pine bark extract) shown to improve visible signs of aging in new study
5. Van Andel research institute study provides new details of fundamental cellular process
6. Broadcast study of ocean acidification to date helps scientists evaluate effects on marine life
7. Study shines light on ways to cut costs for greenhouse growers
8. CWRU study finds the love of a dog or cat helps women cope with HIV/AIDS
9. BU study finds new genetic loci associated with menopause onset
10. New study sheds light on evolutionary origin of oxygen-based cellular respiration
11. Mysterious flotsam in Gulf of Mexico came from Deepwater Horizon rig, WHOI study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2015)... 2015  Navitas today announced that it ... Submission Content Management webinar scheduled on August ... to the Implementation of Regulatory Submission Standards ... industry, vendors, health authorities, consultants and the ... a standard method of implementing electronic submission ...
(Date:8/12/2015)... , Aug. 12, 2015  New research ... can attack Android phones to steal users, fingerprints. ... increasing availability of fingerprint scanners on mobile devices, ... concern. To secure biometrics on mobile devices, HYPR ... augment these convenient authentication systems with strong cryptographic ...
(Date:8/6/2015)... REDWOOD CITY, Calif. , Aug. 6, 2015 ... (D-Silicon Valley) will visit Crossmatch ™ to ... secure networks and protect data. Crossmatch is a ... solutions whose technologies and expertise are helping federal ... operational efficiency and security.   "The ...
Breaking Biology News(10 mins):Navitas, a Key Contributor in IRISS Forum Webinar 2Navitas, a Key Contributor in IRISS Forum Webinar 3HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3Rep. Honda to Visit Crossmatch in Redwood City 2
... in both coconut oil and human breast milk lauric ... to a bioengineering graduate student from the UC San Diego ... system" published in the journal ACS Nano ... to skin-dwelling bacteria ( Propionibacterium acnes ) that cause common ...
... way to identify the hidden genetic material responsible for ... to a deeper understanding of how multiple genes interact ... problems. Writing in the April 15 edition of ... professor in Princeton,s Department of Ecology and Evolutionary Biology ...
... A team of scientists at the University of California, ... genes that initiate and manage cilia formation. Although scientists have ... their role in disease. This new discovery, which may lead ... 15 edition of Nature . Primary ...
Cached Biology News:Treat acne with coconut oil and nano-bombs 2Genetic patterns rise from huge yeast samples 2Genetic patterns rise from huge yeast samples 3Genetic patterns rise from huge yeast samples 4Primary cilia formation provides insight into genetic diseases 2
(Date:9/2/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/cqsxmg/gene_therapy ... report "Gene Therapy - Technologies, Markets and Companies" ... gene therapy are difficult to estimate as there is ... marketed in China since 2004. ... The estimates are based on epidemiology of diseases to ...
(Date:9/2/2015)... 2, 2015 Australian prostate cancer technology company ... science prize recognising ,outstanding, science that uses its patented ... launch a novel prostate cancer diagnostic test known as ... consortium taking out the peer-reviewed Australian Museum Eureka Science ... This prize is awarded for ground breaking ...
(Date:9/2/2015)... 2, 2015 Biovista Inc. ... BeHEARD von 2015 bekanntgeben zu können. Hierbei handelt ... Institute. Biovista unterstützt mit seiner Möglichkeit ... Behandlung anderer Krankheiten als denen, für die ein ... und sein Team bei der Wylder Nation Foundation ...
(Date:9/2/2015)... ... September 02, 2015 , ... Genedata, ... research, today unveiled Genedata Screener ® version 13.0 at ELRIG Drug Discovery ... to market a rich set of new capabilities. Screener now supports High Throughput ...
Breaking Biology Technology:Global Gene Therapy Market Study 2015-2024 - Technologies, Markets and Companies Analysis 2Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 2Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 3Biovista sponsert die Forschung von Wylder Nation Foundation zum Thema Mangel an saurer Sphingomyelinase 2New Genedata Screener 13.0 with Support for High Throughput Flow Cytometry and DMPK Unveiled at ELRIG 2New Genedata Screener 13.0 with Support for High Throughput Flow Cytometry and DMPK Unveiled at ELRIG 3New Genedata Screener 13.0 with Support for High Throughput Flow Cytometry and DMPK Unveiled at ELRIG 4
... High Quality Digital Imaging Solution Now Available in ... Medical Systems, a leading supplier of digital radiography ... and practice management software (VIA(R)), will showcase its ... RapidStudy(TM) DR imaging solutions at the annual Central ...
... April 22 GeneGo, Inc., a leading provider of ... analysis , today announced that the University of Cardiff ... University researchers will have access to GeneGo,s MetaCore, training ... leverage their partner relationship with GeneGo to provide a ...
... The PharmSource ADVANTAGE online service has added two new capabilities ... providers. , ... Fairfax, Virginia (PRWEB) ... provider of business intelligence on contract drug development and manufacture, ...
Cached Biology Technology:Eklin Medical Systems to Showcase RapidStudy(TM) CDx Digital Radiography Systems at CVC East 2Eklin Medical Systems to Showcase RapidStudy(TM) CDx Digital Radiography Systems at CVC East 3Cardiff University Becomes a GeneGo Center of Excellence 2PharmSource Adds New Capabilities to the PharmSource ADVANTAGE Online Service 2
Assay Diluent, 10 L...
... Clone/PAD: ZMD.474. Immunogen: Synthetic peptide ... the mouse junctophilin-3. Specificity: Specific ... junctophilin-3 protein. Reactivity: Mouse (positive ... hippocampus and heart tissues). Applications: ...
...
... Cloning Kit, 40 reactions. Optimized for ... all PCR products with blunt or ... by offering consistently better signal-to-noise ratios ... positive clones.Amplicons generated by proof-reading thermostable ...
Biology Products: