Navigation Links
Study pinpoints genetic variation that raises a risk linked to bisphosphonates
Date:1/27/2012

New York, NY (January 26, 2012) Researchers at the Columbia University College of Dental Medicine have identified a genetic variation that raises the risk of developing serious necrotic jaw bone lesions in patients who take bisphosphonates, a common class of osteoclastic inhibitors. The discovery paves the way for a genetic screening test to determine who can safely take these drugs. The study appears in the online version of the journal The Oncologist.

Oral bisphosphonates are currently taken by some 3 million women in the United States for the prevention or treatment of osteoporosis. In addition, intravenous bisphosphonates are given to thousands of cancer patients each year to control the spread of bone cancer and prevent excess calcium (hypercalcemia) from accumulating in the blood. Bisphosphonates work by binding to calcium in the bone and inhibiting osteoclasts, bone cells that break down the bone's mineral structure.

"These drugs have been widely used for years and are generally considered safe and effective," said study leader Athanasios I. Zavras, DMD, MS, DMSc, associate professor of Dentistry and Epidemiology and Director of the Division of Oral Epidemiology & Biostatistics at the Columbia University College of Dental Medicine. "But the popular literature and blogs are filled with stories of patients on prolonged bisphosphonate therapy who were trying to control osteoporosis or hypercalcemia only to develop osteonecrosis of the jaw."

Osteonecrosis of the jaw, or ONJ, often leads to painful and hard-to-treat bone lesions, which can eventually lead to loss of the entire jaw. Among people taking bisphosphonates, ONJ tends to occur in those with dental disease or those who undergo invasive dental procedures.

There are no reliable figures on the incidence of ONJ in patients taking oral bisphosphonates. Estimates range from 1 in 1,000 to 1 in 100,000 patients for each year of exposure to the medication, accord
'/>"/>

Contact: Karin Eskenazi
ket2116@columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UMass Amherst ecologists among the first to record and study deep-sea fish noises
2. Coastal storms have long-reaching effects, study says
3. Recent study by Mars, Incorporated and partners underscores importance of metabolism in understanding health benefits of cocoa flavanols
4. Pycnogenol (French maritime pine bark extract) shown to improve visible signs of aging in new study
5. Van Andel research institute study provides new details of fundamental cellular process
6. Broadcast study of ocean acidification to date helps scientists evaluate effects on marine life
7. Study shines light on ways to cut costs for greenhouse growers
8. CWRU study finds the love of a dog or cat helps women cope with HIV/AIDS
9. BU study finds new genetic loci associated with menopause onset
10. New study sheds light on evolutionary origin of oxygen-based cellular respiration
11. Mysterious flotsam in Gulf of Mexico came from Deepwater Horizon rig, WHOI study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... the first to show that while the impact of ... negative effects may be reduced by maintaining a healthy ... participants who exercised, slept well and ate well had ... healthy lifestyles, even when they had similar levels of ... in the department of psychiatry at UCSF. "It,s very ...
(Date:7/28/2014)... the United States have a circulatory problem of the ... and may even require surgery in serious cases. This ... in turn, limb amputation. , At The University of ... scientists tested a non-surgical preventative treatment in a mouse ... increased blood circulation. Their proof-of-concept study appears in ...
(Date:7/28/2014)... The genome of Solanum pennellii , a wild ... an international group of researchers including the labs headed ... UC Davis Department of Plant Biology. The new genome ... , The work, published July 27 in the journal ... and colleagues at Aachen University in Germany. The UC ...
Breaking Biology News(10 mins):Healthy lifestyle may buffer against stress-related cell aging, study says 2Scientists discover genetic switch that can prevent peripheral vascular disease in mice 2
... farmers who grow genetically engineered (GE) crops are realizing ... production costs, fewer pest problems, reduced use of pesticides, ... a new report from the National Research Council. ... a main component in Roundup and other commercial weed ...
... levels in crop lands is a key factor that ... according to a paper published in the International ... Current global issues include carbon footprints, water resources and ... growth is often overlooked in the global context. ...
... WASHINGTON, D.C. Scientific breakthroughs in molecular targeting, translational cancer ... than 17,000 scientists from around the world gather at the ... 101st Annual Meeting 2010. "We are now entering ... will have the ability to control this disease in the ...
Cached Biology News:Genetically engineered crops benefit many farmers, but the technology needs proper management to remain effective 2Genetically engineered crops benefit many farmers, but the technology needs proper management to remain effective 3Genetically engineered crops benefit many farmers, but the technology needs proper management to remain effective 4Calculating agriculture's phosphorus footprint 2American Association for Cancer Research hosts 101st Annual Meeting 2010 in Washington, D.C. 2
(Date:7/29/2014)...   Sequenom, Inc. (NASDAQ: SQNM ... analysis solutions, and Mayo Medical Laboratories (MML), ... the United States , have announced a ... "We have great appreciation for Mayo Clinic,s ... welcome the opportunity to partner with the organization,s leading ...
(Date:7/29/2014)... Tough, ultralight foam of atom-thick sheets can be made ... invented at Rice University. , In microscopic images, ... with floors and walls that reinforce each other. The ... and walls of graphene oxide that self-assemble with the ... researchers say the foam could find use in structural ...
(Date:7/29/2014)... 29, 2014  Pomerantz LLP is investigating claims on ... the "Company") (NASDAQ: IPXL).  Such investors are advised to ... or 888-476-6529, ext. 237. The investigation ... directors have violated Sections 10(b) and 20(a) of the ... July 29, 2014, Impax Laboratories, Inc. (the "Company") issued ...
(Date:7/29/2014)... Pa. , July 29, 2014  Discovery ... dedicated to advancing a new standard of respiratory ... results on August 5, 2014 before the open ... The Company will host a live teleconference and ... During the conference call, Discovery Labs, management will ...
Breaking Biology Technology:Sequenom Enters Into License Agreement With Mayo Medical Laboratories 2Sequenom Enters Into License Agreement With Mayo Medical Laboratories 3Sequenom Enters Into License Agreement With Mayo Medical Laboratories 4Tough foam from tiny sheets 2SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Impax Laboratories, Inc. - IPXL 2Discovery Labs to Report 2014 Second Quarter Financial Results and Hold Conference Call on Tuesday, August 5, 2014 at 9:00 a.m. Eastern Time 2
... Dec. 21, 2011  BioStorage Technologies, a global provider of ... logistics for the bioscience industry, is pleased to announce ... fundraising campaign to the Susan G. Komen for the ... Cancer Center. The $1,000 donation was presented to the ...
... 2011 Neogen Corporation (NASDAQ: NEOG ) announces ... Results Webcast When:  Thursday, December 22, 2011 @ ... How:  Live over the Internet -- Simply log ... Contact:  Terry Maynard of Neogen Corporation, +1-800-234-5333. ...
... 21, 2011 Acumen Pharmaceuticals announces today the ... Merck & Co., Inc.) of a 2003 agreement, ... exclusive worldwide rights to develop and commercialize anti-ADDL ... Merck,s decision to discontinue this anti-ADDL ...
Cached Biology Technology:BioStorage Technologies Partners with Susan G. Komen for the Cure Tissue Bank at IU Simon Cancer Center to Raise Money and Awareness for Breast Cancer Research 2BioStorage Technologies Partners with Susan G. Komen for the Cure Tissue Bank at IU Simon Cancer Center to Raise Money and Awareness for Breast Cancer Research 3Acumen Pharmaceuticals Regains Worldwide Rights to Anti-ADDL Antibody Therapeutics and Diagnostics for Alzheimer's Disease From Merck 2
... pump series combines Harvard Apparatuss best pump mechanism, ... wide range of configuration options. A lookup table ... syringes from all the major manufacturers. A bright, ... pertinent information from across the lab. All models ...
... This CLS number is a new product ... number. If showing no availability yet, please ... or contact customer service for assistance. ... Comp Dim: surface area 21 cm 2 ...
... ultimate tool for investigating dynamic events in ... have been limited at wavelengths longer than ... transmit in the deep UV. HORIBA Jobin ... a filter-based confocal system (the DynaMic) to ...
... protein crystallography involves using many of the ... The liquid handling requirements are similar to ... crystallography plates have 24 or 48 wells ... For higher throughput, the number of wells ...
Biology Products: