Navigation Links
Study on effects of resveratrol and quercetin on inflammation and insulin resistance
Date:12/23/2010

A study was carried out to examine the extent to which quercetin and trans-resveratrol (RSV) prevented inflammation or insulin resistance in primary cultures of human adipocytes treated with tumor necrosis factor-a (TNF-a)an inflammatory cytokine elevated in the plasma and adipose tissue of obese, diabetic individuals. Cultures of human adipocytes were pretreated with quercetin and trans-RSV followed by treatment with TNF-a. Subsequently, gene and protein markers of inflammation and insulin resistance were measured. The authors report that quercetin, and to a lesser extent trans-RSV, attenuated the TNF-ainduced expression of inflammatory genes such as interleukin (IL)-6, IL-1b, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1.

Forum members were concerned about certain aspects of the study, especially the extrapolation of in vitro results to in vivo situations. The in vitro conditions the authors describe are minimally representative of an in vivo condition. In vivo, after consumption of quercetin or resveratrol, these compounds undergo extensive metabolism, leading to glucuronidated, sulphated or methylated compounds. In a previous study, quercetin 3-glucoside was transformed to 3,4-dihydroxyphenylacetic acid, acetate and butyrate in cells from human gut; only 3'-methylquercetin has been detected in human plasma, present at a concentration of 0.1 to 0.2 M after 3 h. The authors of the current paper are using concentrations up to 60 M, concentrations which have not been found in vivo.

There were also concerns with the work on cell uptake of quercetin and resveratrol. Primary adipocytes were incubated with the polyphenols, but it is not clear whether or not the concentrations used were subtoxic. Our current knowledge is limited about local concentration of the molecules we are studying in subcellular compartments, their interaction with alternative targets, and eventually their tran
'/>"/>

Contact: R. Curtis Ellison
ellison@bu.edu
508-333-1256
Boston University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study shows drifting fish larvae allow marine reserves to rebuild fisheries
2. New study to examine effects and threats of climate change on plants and animals in Andes
3. Fruit fly study digs deeper into poorly understood details of forming embryos
4. Sea-level study brings good and bad news to Chesapeake Bay
5. Dodds contributes to new national study on nitrogen water pollution
6. New study examines immunity in emerging species of a major mosquito carrer of malaria
7. New study focuses on nitrogen in waterways as cause of nitrous oxide in the atmosphere
8. SU biologist partners with National Park Service to study bison grazing in Yellowstone
9. Despite damage, membrane protein structure can be seen using new X-ray technology, study reveals
10. CSHL study finds that 2 non-coding RNAs trigger formation of a nuclear subcompartment
11. Consortium studying mathematical modeling of influenza infection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... could one day be made out of cocoa, rice ... reporting. The novel process they developed and their results, ... and plastic waste problems, appear in the ACS journal ... and colleagues at the Italian Institute of Technology point ... its production reached 288 million tons worldwide, but its ...
(Date:8/20/2014)... When a colony of honeybees grows to about 4,000 ... reproductive cycle: the building of a special type of ... team of experts from the Department of Neurobiology and ... what starts the reproductive cycle of honeybee colonies. The ... The Science of Nature . , Reproduction isn,t ...
(Date:8/20/2014)... and POINT ROBERTS, Washington , August 20, ... Key Role in Addressing Security Concerns in the Payment Industry? ... news source covering leading sectors including biometrics, issues commentary from ... Jason Peaslee , Managing Partner at Thrive Analytics, ... Gino Pereira , CEO of NXT-ID, Inc. (OTCBB: NXTD) ( ...
Breaking Biology News(10 mins):Worker bees 'know' when to invest in their reproductive future 2Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 2Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 3Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 4Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 5Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 6Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 7
... An in-depth study by Sandia National Laboratories and ... waste and dedicated energy crops could sustainably replace nearly ... The goal of the "90-Billion Gallon Biofuel ... large volume of cellulosic biofuel could be sustainably produced, ...
... that road salt used throughout the winter is making ... aquatic life and drinking water. The research indicates ... judicious use of road salt could help lessen the ... a video with research team leader Heinz Stefan, go ...
... elevations in Arizona,s Santa Catalina Mountains as summer temperatures ... Arizona in Tucson. The flowering ranges of 93 ... to where the same species flowered the previous ten ... the region increased about 1.8 degree Fahrenheit (1 degree ...
Cached Biology News:Biofuels can provide viable, sustainable solution to reducing petroleum dependence 2Biofuels can provide viable, sustainable solution to reducing petroleum dependence 3U of Minnesota research finds most road salt is making it into the state's lakes and rivers 2Plants take a hike as temperatures rise 2Plants take a hike as temperatures rise 3
(Date:8/20/2014)... August 20, 2014 The 6th ... being held on October 29-30 in San Francisco, CA. ... academic and government researchers and clinicians focused on addressing ... , In the twelve years since the sequencing ... have been introduced with pharmacogenetic information in the label ...
(Date:8/20/2014)... WriteResult®, a leading provider of Electronic Patient Outcome ... myPROpad™ ePRO tablet with the addition of a touchscreen ... widely used and well-respected Patient Reported Outcome (PRO) instruments ... used during clinical trials and in other health care ... to demonstrate Health-Related Quality of Life outcomes (HRQoL) resulting ...
(Date:8/19/2014)... Research and Markets  has announced the addition of the "Cell ... to their offering. This report analyzes the worldwide ... the following Product Segments: Media, Sera, and Reagents. The ... , Japan , Europe ... . Annual estimates and forecasts are provided for the period ...
(Date:8/19/2014)... (PRWEB) August 19, 2014 Robin Williams’ ... disease can take on an individual. Symptoms range ... facial expression, problems swallowing and severe depression. Parkinson’s ... dying off of dopamine producing neurons of the brain. ... a disease that slowly and progressively gets worse, they ...
Breaking Biology Technology:6th Annual Personalized and Precision Medicine Conference Bringing Together Thought Leaders to Discuss Clinical Implementation, Dx Reimbursement, Big Data, and Sequencing 2EQ-5D™ Assessment Now Available for iPad 2Global Cell and Tissue Culture Supplies - Strategic Business Report 2014 2As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 2As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 3
... Silence Therapeutics plc (AIM: SLN) ("Silence", the "Group" or ... company, today announces the appointment of Thomas Christély as ... based at Silence,s facility in Berlin. Thomas ... in corporate and business development and finance. He was ...
... researchers have developed a new technique to reach neurons ... and noninvasively. Up until now, scientists have thought that ... required. But in this new study, the Columbia Engineering ... can open the blood-brain barrierwith the added advantages of ...
... Korea, August 8, 2011Can a flexible LED conformably placed on ... human brain, or rolled upon the blood vessels, diagnose or ... in the near future. The team of Professor Keon ... developed a new concept: a biocompatible, flexible Gallium Nitride (GaN) ...
Cached Biology Technology:Appointment of Chief Executive Officer 2Appointment of Chief Executive Officer 3Appointment of Chief Executive Officer 4Engineers use short ultrasound pulses to reach neurons through blood-brain barrier 2
Mouse monoclonal [M7-PB-E9] to pan alpha Sodium Potassium ATPase ( Abpromise for all tested applications)....
Transcription factor Sp2. [Source:Uniprot/SWISSPROT;Acc:Q02086] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
... [EP282Y] to Asparagine synthetase ( ... applications). Antigen: ... residues in the C-terminus of ... Entrez GeneID: 440 ...
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
Biology Products: