Navigation Links
Study offers new insights into the mechanics of muscle fatigue
Date:1/17/2013

A study in The Journal of General Physiology examines the consequences of muscle activity with surprising results, indicating that the extracellular accumulation of potassium that occurs in working muscles is considerably higher than previously thought.

Muscle excitation involves the influx of sodium ions and efflux of potassium ions. Although the fraction of ions that cross the muscle membrane with each contraction is minute, repeated activity can lead to substantial changes in the intracellular and extracellular concentrations of sodium and potassium ions. The extent of these changes, however, has been unclear. Now, Torben Clausen from Aarhus University in Denmark provides quantitative analyses of the changes in intracellular and extracellular ion concentration resulting from stimulation of a leg muscle in rats, providing insight into how they vary with muscle activity.

Clausen measured the changes in concentration of sodium, potassium, and chloride ions in working rat extensor digitorum longus (ESL) muscles. Remarkably, when their muscles were stimulated to fire at a rate of 5 Hz (comparable to that in the legs of a person riding a bicycle) for five minutes, sufficient intracellular potassium was lost to lead to an extracellular concentration that would interfere with further excitation. These results suggest that accumulation of extracellular potassium is a much larger contributor to muscle fatigue than previously thought, which may be of particular importance in such conditions as hyperkalemic periodic paralysis and other channelopathies that affect skeletal muscle. These changes in ion distribution are opposed through the action of the "Na+/K+ pump"which expends energy to move sodium out of the cell and potassium into itand will therefore be even more pronounced under disease- and injury-related conditions associated with decreased pump activity.


'/>"/>

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... significant health risk to people with asthma according to a ... Clinical Immunology . , By critically reviewing the findings from ... that the presence of several types of mould can lead ... the likelihood of developing the condition. , The research has ... Medical School and is the first time all of the ...
(Date:8/28/2014)... California, and Alaska totaled 515 million board feet in ... of more than 10 percent compared to the first ... Research Station reported today. During this same period, West ... million board feet. , The total value of these ... $390 million in the same quarter, while the total ...
(Date:8/28/2014)... Ludwig-Maximilians-Universitaet (LMU) in Munich have assigned a number ... predatory arthropods. These animals lived in shallow marine ... forms found in Jurassic strata. , Before ... marine habitat and were fossilized some 435 million ... of the Silurian seas although they were ...
Breaking Biology News(10 mins):Indoor mold poses health risk to asthma sufferers 2West coast log exports up, lumber exports down in second quarter of 2014 2Paleontology: Oldest representative of a weird arthropod group 2
... become after being exposed to a specialized electrical field ... or a stage of cancer already invading other parts ... electrical process and found cells that expanded the most ... has spread beyond its point of origin. The technique ...
... German . Within the last few years ... has been increased considerably. A worthwhile effort as, after ... and safe methods of transport checks are offered by terahertz ... however, it has to be measured quantitatively, so that damage ...
... the worlds of law, geography, economics, public health ... College London) on Friday September 19th to examine ... locally-rooted champions for global sustainability, reaching out to ... change. The symposium, which is called: "The Sustainable ...
Cached Biology News:Expanding cell girth indicates seriousness of breast cancer 2Checking people at airports -- with terahertz radiation 2Universities develop a more sustainable future 2
(Date:8/28/2014)... Vt. (PRWEB) August 28, 2014 ... testing around the world is available from Strategic ... diagnostics companies. “ Industrial Microbiology Market Review, Fourth ... Industrial Market ” (IMMR—4) tracks and compares microbiology ... in North America, Europe and Asia, and forecasts ...
(Date:8/28/2014)... Supplementing their complete line of ... Eppendorf Safe Lock Centrifuge Tubes . This ... quality tubes at an affordable price. Eppendorf Safe ... chemical, medical, pharmaceutical, and life science research and ... able to afford Eppendorf products. , Eppendorf is ...
(Date:8/27/2014)... 27, 2014 Green & Grow Inc. ... B funding and secured Otter Capital as a significant ... accelerate commercialization of GGI’s Agriplier™ technology, building on recent ... , “Since our first meeting, we have been impressed ... product space,” said Alan Sobba, President and CEO of ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportlinker.com ... is available in its catalogue: ... http://www.reportlinker.com/p02316661/Global-Biodegradable-Packaging-Materials-Market-2014-2018.html ... materials that are readily decomposed by the ... conventional non-degradable packaging in terms of raw ...
Breaking Biology Technology:2 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 3Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3Global Biodegradable Packaging Materials Market 2014-2018 2Global Biodegradable Packaging Materials Market 2014-2018 3Global Biodegradable Packaging Materials Market 2014-2018 4Global Biodegradable Packaging Materials Market 2014-2018 5Global Biodegradable Packaging Materials Market 2014-2018 6Global Biodegradable Packaging Materials Market 2014-2018 7
... Pa. , Aug. 2 Tengion Inc. (Nasdaq: ... Brian Davis to the position of Chief Financial Officer.  Mr. Davis ... company using enzymatic technologies to develop improved protein therapeutics. At its peak, ... three sites.  , , , ...
... 15,000 of them. A Northwestern University research team ... with tiny beams of light using an innovative nanofabrication ... new method, which could do for nanofabrication what the ... will be published Aug. 1 by the journal ...
...  The European Commission announced that it has granted import, ... developed by DuPont (NYSE: ... AgroSciences LLC , a wholly owned subsidiary of   The ... insect protection and the Herculex® RW trait stack (also known ...
Cached Biology Technology:Tengion Appoints A. Brian Davis Chief Financial Officer 215,000 beams of light 215,000 beams of light 3European Union Approves Maize with Herculex® I/Herculex® RW and Herculex® RW/ Herculex® I/Roundup Ready® Corn 2 Trait Stacks for Import, Food, Feed & Processing 2European Union Approves Maize with Herculex® I/Herculex® RW and Herculex® RW/ Herculex® I/Roundup Ready® Corn 2 Trait Stacks for Import, Food, Feed & Processing 3European Union Approves Maize with Herculex® I/Herculex® RW and Herculex® RW/ Herculex® I/Roundup Ready® Corn 2 Trait Stacks for Import, Food, Feed & Processing 4
"BioTracker 6X Bromophenol Blue Tracking Dye is composed of 60% St DI H2O, 30% Glycerol, 10% 10XTE, 0.25% BPB Dye and 0.85% SDS....
Request Info...
Agarose, low melting/gelling temperature, high MW separation (>1000 bp), 25 g. Suitable for enzymatic modifications. Nuclease-free.Gel point: 24-30 C, EEO (-mr): 300 gm/cm2. Category: Nucleotides &...
Request Info...
Biology Products: