Navigation Links
Study offers new clues about hereditary spastic paraplegia
Date:7/8/2011

ow it worked."

Membranes are both the brick walls and the zip-lock bags of microbiology. Every living cell is encased in a water-tight membrane of fatty acids, and all of the cell's interactions with the outside world are mediated by what can and cannot pass through that membrane. When a virus invades a healthy cell, it uses membrane fusion. When a sperm fertilizes an egg, it uses membrane fusion. Membranes are also used inside the cell, where they serve as biochemical reaction chambers, as cargo containers and as pipelines.

To find out how atlastin initiates membrane fusion, McNew, Daga and colleagues conducted experiments involving the fruit-fly version of atlastin, which is remarkably similar to the version found in humans. By selectively disabling portions of the protein and examining how those modifications affected atlastin's ability to promote membrane fusion in the test tube and cell cultures, the team gradually built a picture of how atlastin works. They found that pairs of atlastin proteins, each of which is anchored in a separate membrane, can bind to one another when both partners are functional enzymes. That action draws the separated membranes together and allows fusion to occur.

Additionally, they found that a small piece near the end of atlastin was required for fusion activity.

"Atlastin has a fairly short tail, which protrudes from the site where the protein is anchored into the membrane," Daga said. "When we deleted this tail, we found that the protein could not stimulate membrane fusion, even when the two copies bound together normally."

McNew said prior gene sequencing studies have show that some HSP patients have genetic mutations that result in defects in this critical tail region of the atlastin protein.

"This study, as well as work by others, suggests the area of the cell where atlastin promotes membrane fusion, the endoplasmic reticulum, is a good target for future studies into the caus
'/>"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Study suggests new strategy to prevent infertility, birth defects
2. UTMB-led researchers awarded $7.8 million for Gulf spill study
3. LSUHSC conducts landmark study of mid, long-term health effects of oil exposure
4. Nordic study shows marginally higher but overall low risk of stillbirth in ART children
5. First whole-genome lung cancer study by TGen and Virginia G. Piper Cancer Center set for conference
6. Twin study shows lifestyle, diet can significantly influence course of macular degeneration
7. Study: Preventive use of one form of natural vitamin E may reduce stroke damage
8. Behavioral treatment for migraines a cost-effective alternative to meds, study finds
9. ARS and cooperators study cotton gin dust emissions
10. Study finds pregnancy and birth environment may affect development of autism in twins
11. Study shows answers for treating obesity-related diseases may reside in fat tissue
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study offers new clues about hereditary spastic paraplegia
(Date:8/19/2014)... this week,s Eos: Long-Term Ecological Research and Network-Level Science, ... how a wide range of ecosystems was responding to ... be particularly powerful if it coupled multiple decades of ... long-term experiments and models from dozens of different ecosystem ... is the Long-Term Ecological Research (LTER) Network, which will ...
(Date:8/19/2014)... fish purchased at retail seafood counters in 10 ... can expose consumers to unexpectedly high levels of ... falsely present a fish of the same species, ... dangerous mislabeling offense, according to new research by ... labeling of seafood is essential to allow consumers ...
(Date:8/19/2014)... Some infants born with neonatal abstinence syndrome (NAS) ... difficult time going through withdrawal than others, but ... genetic and epigenetic (when genes are turned on ... potential factors, researchers at Boston University School of ... a first of its kind study to identify ...
Breaking Biology News(10 mins):This week from AGU: Long-term ecological research, predicting cholera outbreaks 2Seafood substitutions can expose consumers to unexpectedly high mercury 2Seafood substitutions can expose consumers to unexpectedly high mercury 3In-utero methadone, Subutex exposure could alter gene expression, cause severe Neonatal Abstience Syndrome 2
... University of North Carolina at Chapel Hill School of Medicine ... collateral circulation the "back-up" blood vessels that can provide ... attack or stroke. The new knowledge could help inform ... drugs or procedures that can cause new collaterals to form ...
... "The Sign of the Four" Sherlock Holmes tells Watson he ... and pipe-tobacco, "with colored plates illustrating the difference in the ... miscreants who happen to smoke during the commission of a ... pipe dottle don,t have a patch on geologists and the ...
... closer to understanding what triggers muscle damage in one ... facioscapulohumeral muscular dystrophy (FSHD). FSHD affects about 1 ... and wasting of muscles in the face, shoulders and ... disabling. The facial weakness in FSHD, for example, ...
Cached Biology News:Genetics underlie formation of body's back-up bypass vessels 2Geologists revisit the Great Oxygenation Event 2Geologists revisit the Great Oxygenation Event 3Geologists revisit the Great Oxygenation Event 4Geologists revisit the Great Oxygenation Event 5Geologists revisit the Great Oxygenation Event 6Discovery opens door to therapeutic development for FSH muscular dystrophy 2
(Date:8/20/2014)... Aug. 20, 2014 /PRNewswire-iReach/ -- A case study ... between the school,s bioengineering department and the Intel® ... Intel® Software Academic Program, UCSD,s research focuses on ... human body.  Photo - ... the work of Dr. Todd P. Coleman ...
(Date:8/19/2014)... Piscataway, NJ (PRWEB) August 20, 2014 ... engineering and regenerative medicine is an inadequate vascular ... engineered constructs and decellularized tissues is critical for ... Researchers have attempted to mitigate deficiencies in vascularization ... including adding scaffold bioactivity, optimizing scaffold design and ...
(Date:8/19/2014)... 2014 Cellgen Diagnostics ... to fund a corporate lab for its genetic-based ... development is a critical component in the move ... the implementation of personalized medicine – a more ... , Indiegogo contributions will support Cellgen’s intent to ...
(Date:8/19/2014)... , Aug. 19, 2014 ... addition of the "Spectroscopy Equipment and ... report to their offering. ... Spectroscopy Equipment and Accessories in US$ Thousands ... (UV-Vis spectrophotometers, Raman Spectrometers, NMR-EPR Spectrometers, Near ...
Breaking Biology Technology:Intel and University of San Diego Bioengineering Department Release Case Study on Health Sciences Research 2Vascularization in Tissue Engineering Highlighted at 12th New Jersey Symposium on Biomaterials Science 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 3Global Spectroscopy Equipment and Accessories - Strategic Business Report 2014 2
... Therapy Remains an Important Option for Women Seeking Relief of ... ... data from the Women,s Health Initiative (WHI) study published,today in the ... the appropriate use of hormone therapy when it is,prescribed to symptomatic, ...
... (Nasdaq: DCGN ) today announced that it will report ... issued on Wednesday, March 12,after the close of the market ... its conference call to discuss these results and recent,operating highlights ... noon GMT., The webcast can be accessed through the ...
... and Work/Life Innovations into Next Generation Life/Health Management ... ... Mass., March 4 CaseNET, Inc., a provider of,innovative enterprise care ... (NYSE: CNC ), has selected,the CaseNET platform to support its ...
Cached Biology Technology:WHI Findings Published in JAMA Do Not Affect Clinical Guidance for the Appropriate Use of Hormone Therapy 2WHI Findings Published in JAMA Do Not Affect Clinical Guidance for the Appropriate Use of Hormone Therapy 3WHI Findings Published in JAMA Do Not Affect Clinical Guidance for the Appropriate Use of Hormone Therapy 4deCODE genetics Announces Webcast of Conference Call to Discuss Full-year 2007 Financial Results 2Nurtur(TM) Selects CaseNET to Enable Integrated Health and Life Management Capabilities 2
... At the forefront of Agilent analytical ... Built-in local area networking (LAN) allows you ... sites--for fast and informed decision making. Just ... has all the flexibility and performance needed ...
... Inc.'s CP-4900 is a rugged, ... delivers the information you need ... the composition of gas mixtures ... micro-Gas Chromatograph generates more data ...
... GC system combines world-class performance hardware, Cerity ... Agilents world-renowned support and columns, as well ... combination that lets you reach uncompromising results ... dependable data. The Agilent 6820 GC system ...
... Peroxisome Proliferator-Activated Receptor-gamma (PPARGamma) Competitor ... and efficient method for studying ... using fluorescence polarization (FP). The ... domain (PPARGamma-LBD) with an N-terminal ...
Biology Products: