Navigation Links
Study offers new clues about hereditary spastic paraplegia
Date:7/8/2011

HOUSTON -- (July 8, 2011) -- New research from Rice University and Italy's Eugenio Medea Scientific Institute is yielding clues about hereditary spastic paraplegia (HSP), a group of inherited neurological disorders that affect about 20,000 people in the United States. A study in the July 5 issue of the Proceedings of the National Academy of Sciences offers the first detailed account of the biochemical workings of atlastin, a protein produced by one of the genes linked to HSP.

The primary symptoms of HSP are progressive spasticity and weakness of the leg and hip muscles. This results from the slow degeneration of the nerves that carry signals from the spinal column to the legs, feet and toes. While scientists know that HSP can result from more than two dozen different genetic mutations, they don't know how the mutations cause nerve degeneration.

"We discovered a couple of years ago that atlastin plays a key role in building and maintaining an important internal compartment of healthy cells called the endoplasmic reticulum," said Rice biochemist James McNew, lead co-author of the new study. "HSP is known to primarily affect long nerve cells that can stretch from the lower back all the way to the base of the leg. It appears that atlastin plays a particularly crucial role in maintaining the health of these cells, and we want to know why."

McNew, associate professor of biochemistry and cell biology at Rice, and Andrea Daga, a scientist at the Medea Institute, determined in 2009 that atlastin was one of the rare breed of proteins that can cause membrane fusion.

"Membrane fusion is a fundamental process involved in many cell functions, but only a few proteins can initiate it," McNew said. "Until 2009, we thought all membrane fusion proteins operated in the same basic way. Atlastin was completely different because it's an enzyme that utilizes chemical energy to drive fusion. We really had to start from scratch to determine h
'/>"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Study suggests new strategy to prevent infertility, birth defects
2. UTMB-led researchers awarded $7.8 million for Gulf spill study
3. LSUHSC conducts landmark study of mid, long-term health effects of oil exposure
4. Nordic study shows marginally higher but overall low risk of stillbirth in ART children
5. First whole-genome lung cancer study by TGen and Virginia G. Piper Cancer Center set for conference
6. Twin study shows lifestyle, diet can significantly influence course of macular degeneration
7. Study: Preventive use of one form of natural vitamin E may reduce stroke damage
8. Behavioral treatment for migraines a cost-effective alternative to meds, study finds
9. ARS and cooperators study cotton gin dust emissions
10. Study finds pregnancy and birth environment may affect development of autism in twins
11. Study shows answers for treating obesity-related diseases may reside in fat tissue
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study offers new clues about hereditary spastic paraplegia
(Date:7/23/2014)... This news release is available in German . ... shape and stability to cells, drive metabolic processes and ... into complex three-dimensional shapes. Scientists at the Max Planck ... that proteins can be constructed of similar amino acid ... suggests that the proteins that exist today arose from ...
(Date:7/23/2014)... Innovative Networking in personalized cancer medicine, (the WIN consortium), ... Thomas Jefferson University will be one of ... this prestigious group in the Tri-State Area. The goal ... personalized medicine to the patient by forging collaborations between ... participation in the WIN consortium means Jefferson cancer patients ...
(Date:7/23/2014)... As local and national governments struggle to deal with ... now refining the picture of just how much there ... the ACS journal Environmental Science & Technology , ... that developed countries discard floods into just seven developing ... people who live there. , Knut Breivik and colleagues ...
Breaking Biology News(10 mins):Protein evolution follows a modular principle 2New partnership brings more personalized cancer treatment to Philadelphia 2
... an unexpected connection with jet engines. Researchers at Scripps ... the recorded sounds from two volcanoes and uncovered a ... research findings provide scientists with a more useful probe ... sound that is lower in frequency than 20 cycles ...
... on environmentally friendly farming practices and potentially useful ... opportunities, and renewable energy sources, according to a ... the International Journal of Private Law . ... University, Topeka, Kansas, asks what can leaders do ...
... , Montreal, April 8, 2009 Research infrastructure at ... centres has received a boost, thanks to the Canada Foundation ... Quebec and the private sector. The CFI has awarded $854,098 ... Montral, the Sainte-Justine University Hospital Research Center and the Centre ...
Cached Biology News:Study compares sound from exploding volcanoes with jet engines 2Ma and Pa solutions to global warming 2CFI awards $854,098 to University of Montreal and partners 2CFI awards $854,098 to University of Montreal and partners 3
(Date:7/23/2014)... made great strides in saving China,s endangered national treasure, ... 65 giant panda reserves that have been established and ... 1596 pandas remain in the wild. , Breeding ... the panda by improving genetic diversity, avoid inbreeding and ... are these high-profile programs doing so far? , In ...
(Date:7/23/2014)... 2014 /PRNewswire-iReach/ -- Think Drinks are a neuroscience-backed drink ... term. They are the first functional focus beverage to ... an alternative to the temporary fix associated with energy ... July 29, 2014, with hopes to raise $50,000 over ... - http://photos.prnewswire.com/prnh/20140723/129697 Think Drinks ...
(Date:7/23/2014)... year, Formedix celebrated its partnership with ... management solutions for clinical trials. The company launched its ... capture (EDC) and clinical data management. Formedix, a renowned ... TrialMaster to its Transform for EDC product line. This ... is being released this week, in response to market ...
(Date:7/23/2014)... (PRWEB) July 23, 2014 StemGenex® ... therapy in the US aimed at improving the lives ... newest clinical study for Parkinson’s disease. StemGenex believes ... stem cell therapy are paramount when providing care to ... study makes stem cell therapy accessible to the millions ...
Breaking Biology Technology:truBrain Neuroscientists To Launch More Effective, Healthier Alternative To Energy Drinks On Indiegogo 2Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 2Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 3StemGenex® Gives Hope to Parkinson’s Patients through New Stem Cell Clinical Study 2StemGenex® Gives Hope to Parkinson’s Patients through New Stem Cell Clinical Study 3
... BRANFORD, Connecticut and STATE COLLEGE, Pennsylvania, May 9, ... Roche Company, and SoftGenetics announced today that the ... designed to provide users of 454 Sequencing Systems ... options provided by SoftGenetics NextGENe® software. ...
... JERICHO, N.Y., May 8, 2012 Health Care ... response to continued recent devastating natural and man-made ... the HCCS online training course, "Bioterrorism and Disaster ... (Logo:  http://photos.prnewswire.com/prnh/20061010/NYTU194LOGO ) "HCCS ...
... COPENHAGEN, May 8, 2012  Ekahau ... Location Systems (RTLS), today announced the launch of its newest ... Pager .  The B4 features an OLED text display and multiple ... to acknowledge receipt or to initiate calls and alarms. A unique ...
Cached Biology Technology:Roche 454 Life Sciences and SoftGenetics Sign Co-Promotion Agreement for Next-Gen Sequencing Software Tools 2Roche 454 Life Sciences and SoftGenetics Sign Co-Promotion Agreement for Next-Gen Sequencing Software Tools 3Free Disaster Preparedness Online Training Course 2Ekahau Launches Next Generation Wi-Fi RTLS Staff Badge and Pager 2Ekahau Launches Next Generation Wi-Fi RTLS Staff Badge and Pager 3
Goat polyclonal to Dysadherin ( Abpromise for all tested applications). entrezGeneID: 53827...
UBC13 Antibody...
... SAPK/JNK (Thr183/Tyr185) Antibody Kit Kit ... Catalog #9251, 200 ul SAPK/JNK (56G8) ... SAPK/JNK Cell Extracts, Catalog #9253, (4 ... Catalog #7074, 100 ul Anti-biotin IgG, ...
Vascular Endothelial Growth Factor C Class: Antibody Product Group: Angiogensis...
Biology Products: